{"id":"https://openalex.org/W2328014372","doi":"https://doi.org/10.1021/cr100222q","title":"Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology","display_name":"Mechanisms of Chemical Carcinogenicity and Mutagenicity: A Review with Implications for Predictive Toxicology","publication_year":2011,"publication_date":"2011-01-25","ids":{"openalex":"https://openalex.org/W2328014372","doi":"https://doi.org/10.1021/cr100222q","mag":"2328014372","pmid":"https://pubmed.ncbi.nlm.nih.gov/21265518"},"language":"en","primary_location":{"id":"doi:10.1021/cr100222q","doi":"https://doi.org/10.1021/cr100222q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cr100222q","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2328014372"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084913709","display_name":"Romualdo Benigni","orcid":"https://orcid.org/0000-0003-0943-1811","observed_orcids":["https://orcid.org/0000-0003-0943-1811"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Romualdo Benigni","raw_affiliation_strings":["Istituto Superiore di Sanita\u2019, Environment and Health Department, Viale Regina Elena, 299 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Superiore di Sanita\u2019, Environment and Health Department, Viale Regina Elena, 299 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056387919","display_name":"Cecilia Bossa","orcid":"https://orcid.org/0000-0003-2084-2902","observed_orcids":["https://orcid.org/0000-0003-2084-2902"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Bossa","raw_affiliation_strings":["Istituto Superiore di Sanita\u2019, Environment and Health Department, Viale Regina Elena, 299 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Superiore di Sanita\u2019, Environment and Health Department, Viale Regina Elena, 299 00161 Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084913709"],"corresponding_institution_ids":["https://openalex.org/I27897274"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9169,"has_fulltext":false,"cited_by_count":393,"citation_normalized_percentile":{"value":0.89099099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"111","issue":"4","first_page":"2507","last_page":"2536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemical-carcinogenicity","display_name":"chemical carcinogenicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/carcinogenesis-mechanisms","display_name":"carcinogenesis mechanisms","score":0.6650000214576721},{"id":"https://openalex.org/keywords/mutagenesis-mechanism","display_name":"mutagenesis mechanism","score":0.8960000276565552},{"id":"https://openalex.org/keywords/predictive-toxicology","display_name":"predictive toxicology","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.8500000238418579},{"id":"https://openalex.org/keywords/amines","display_name":"amines","score":0.7680000066757202},{"id":"https://openalex.org/keywords/aromatic-compounds","display_name":"aromatic compounds","score":0.9800000190734863},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.7003166675567627},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4614025950431824},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.449733167886734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4252825975418091},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.36023953557014465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28755754232406616},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2847342789173126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/cr100222q","doi":"https://doi.org/10.1021/cr100222q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cr100222q","pdf_url":null,"source":{"id":"https://openalex.org/S41143188","display_name":"Chemical Reviews","issn_l":"0009-2665","issn":["0009-2665","1520-6890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Reviews","raw_type":"journal-article"},{"id":"pmid:21265518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21265518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":303,"referenced_works":["https://openalex.org/W103530093","https://openalex.org/W137585523","https://openalex.org/W168276155","https://openalex.org/W226418965","https://openalex.org/W582668607","https://openalex.org/W909990993","https://openalex.org/W1484987052","https://openalex.org/W1516032052","https://openalex.org/W1521598031","https://openalex.org/W1534849470","https://openalex.org/W1556247718","https://openalex.org/W1571176283","https://openalex.org/W1590789852","https://openalex.org/W1591569697","https://openalex.org/W1598239887","https://openalex.org/W1812869115","https://openalex.org/W1884352903","https://openalex.org/W1964076639","https://openalex.org/W1964788285","https://openalex.org/W1965543876","https://openalex.org/W1965905617","https://openalex.org/W1967281255","https://openalex.org/W1967744043","https://openalex.org/W1968049462","https://openalex.org/W1969345233","https://openalex.org/W1969419166","https://openalex.org/W1969727351","https://openalex.org/W1970197319","https://openalex.org/W1970202530","https://openalex.org/W1973410261","https://openalex.org/W1973985648","https://openalex.org/W1973995361","https://openalex.org/W1975652648","https://openalex.org/W1975773020","https://openalex.org/W1975894067","https://openalex.org/W1976667472","https://openalex.org/W1977173233","https://openalex.org/W1977340881","https://openalex.org/W1979605074","https://openalex.org/W1980646946","https://openalex.org/W1982483359","https://openalex.org/W1982952754","https://openalex.org/W1983439633","https://openalex.org/W1983515051","https://openalex.org/W1983684582","https://openalex.org/W1984387307","https://openalex.org/W1985494727","https://openalex.org/W1985784646","https://openalex.org/W1985895020","https://openalex.org/W1986443759","https://openalex.org/W1987021965","https://openalex.org/W1988242038","https://openalex.org/W1988252885","https://openalex.org/W1988743775","https://openalex.org/W1988839612","https://openalex.org/W1989515558","https://openalex.org/W1989729701","https://openalex.org/W1991667458","https://openalex.org/W1991871732","https://openalex.org/W1992986018","https://openalex.org/W1993630555","https://openalex.org/W1993813448","https://openalex.org/W1995442490","https://openalex.org/W1999235659","https://openalex.org/W2001839857","https://openalex.org/W2002422732","https://openalex.org/W2003268550","https://openalex.org/W2004386347","https://openalex.org/W2004463118","https://openalex.org/W2005156172","https://openalex.org/W2005604459","https://openalex.org/W2008146644","https://openalex.org/W2009268549","https://openalex.org/W2010205595","https://openalex.org/W2011079789","https://openalex.org/W2011089596","https://openalex.org/W2011299998","https://openalex.org/W2011991776","https://openalex.org/W2012092858","https://openalex.org/W2012207830","https://openalex.org/W2012554060","https://openalex.org/W2012995566","https://openalex.org/W2013331166","https://openalex.org/W2013827205","https://openalex.org/W2014311652","https://openalex.org/W2014509727","https://openalex.org/W2015534707","https://openalex.org/W2015583487","https://openalex.org/W2015712433","https://openalex.org/W2015877651","https://openalex.org/W2016319165","https://openalex.org/W2016874323","https://openalex.org/W2018766597","https://openalex.org/W2019414437","https://openalex.org/W2019533087","https://openalex.org/W2019981251","https://openalex.org/W2020894239","https://openalex.org/W2021663692","https://openalex.org/W2021796577","https://openalex.org/W2022669488","https://openalex.org/W2023527995","https://openalex.org/W2023613474","https://openalex.org/W2024007533","https://openalex.org/W2024317369","https://openalex.org/W2026110854","https://openalex.org/W2026884630","https://openalex.org/W2027656802","https://openalex.org/W2027687397","https://openalex.org/W2028103496","https://openalex.org/W2030846837","https://openalex.org/W2031109095","https://openalex.org/W2032810925","https://openalex.org/W2032923748","https://openalex.org/W2033592843","https://openalex.org/W2033602942","https://openalex.org/W2034082180","https://openalex.org/W2034243532","https://openalex.org/W2035043537","https://openalex.org/W2035538685","https://openalex.org/W2035683662","https://openalex.org/W2035742760","https://openalex.org/W2037382441","https://openalex.org/W2037688575","https://openalex.org/W2037823508","https://openalex.org/W2037915637","https://openalex.org/W2040452819","https://openalex.org/W2040539854","https://openalex.org/W2041005506","https://openalex.org/W2041366581","https://openalex.org/W2041554057","https://openalex.org/W2042703563","https://openalex.org/W2043172711","https://openalex.org/W2043189747","https://openalex.org/W2043426707","https://openalex.org/W2043776026","https://openalex.org/W2044180329","https://openalex.org/W2045294557","https://openalex.org/W2048326558","https://openalex.org/W2048553024","https://openalex.org/W2049041530","https://openalex.org/W2050776011","https://openalex.org/W2051271640","https://openalex.org/W2051278645","https://openalex.org/W2051577430","https://openalex.org/W2051703061","https://openalex.org/W2052028397","https://openalex.org/W2052226480","https://openalex.org/W2052776535","https://openalex.org/W2053642664","https://openalex.org/W2054100515","https://openalex.org/W2054574591","https://openalex.org/W2055241430","https://openalex.org/W2055689623","https://openalex.org/W2056038686","https://openalex.org/W2056562706","https://openalex.org/W2057728329","https://openalex.org/W2058040542","https://openalex.org/W2058174689","https://openalex.org/W2059413530","https://openalex.org/W2061389725","https://openalex.org/W2061541731","https://openalex.org/W2061973973","https://openalex.org/W2062129585","https://openalex.org/W2062229879","https://openalex.org/W2062363164","https://openalex.org/W2062892492","https://openalex.org/W2063070387","https://openalex.org/W2063587997","https://openalex.org/W2064144593","https://openalex.org/W2065070740","https://openalex.org/W2065959399","https://openalex.org/W2066314749","https://openalex.org/W2069754280","https://openalex.org/W2069882446","https://openalex.org/W2069895556","https://openalex.org/W2070867404","https://openalex.org/W2071048769","https://openalex.org/W2071204626","https://openalex.org/W2071493323","https://openalex.org/W2071508893","https://openalex.org/W2071561301","https://openalex.org/W2072513475","https://openalex.org/W2073150308","https://openalex.org/W2073487738","https://openalex.org/W2073953610","https://openalex.org/W2075007582","https://openalex.org/W2076244798","https://openalex.org/W2076398537","https://openalex.org/W2076879979","https://openalex.org/W2077579733","https://openalex.org/W2078901178","https://openalex.org/W2080249751","https://openalex.org/W2080589329","https://openalex.org/W2081034228","https://openalex.org/W2083079235","https://openalex.org/W2083605403","https://openalex.org/W2084319555","https://openalex.org/W2084597330","https://openalex.org/W2084914439","https://openalex.org/W2085427957","https://openalex.org/W2085966273","https://openalex.org/W2086052702","https://openalex.org/W2087626034","https://openalex.org/W2088524561","https://openalex.org/W2088707304","https://openalex.org/W2089160912","https://openalex.org/W2089415609","https://openalex.org/W2089564101","https://openalex.org/W2090323663","https://openalex.org/W2090398170","https://openalex.org/W2090469880","https://openalex.org/W2090882120","https://openalex.org/W2090990681","https://openalex.org/W2091958115","https://openalex.org/W2092032044","https://openalex.org/W2092159314","https://openalex.org/W2092202938","https://openalex.org/W2092539345","https://openalex.org/W2092969822","https://openalex.org/W2093162294","https://openalex.org/W2093165226","https://openalex.org/W2093404056","https://openalex.org/W2093520294","https://openalex.org/W2093847446","https://openalex.org/W2094481836","https://openalex.org/W2094984629","https://openalex.org/W2095157451","https://openalex.org/W2096497526","https://openalex.org/W2096612883","https://openalex.org/W2097559947","https://openalex.org/W2098849527","https://openalex.org/W2099481136","https://openalex.org/W2100908704","https://openalex.org/W2103599338","https://openalex.org/W2104859355","https://openalex.org/W2106982482","https://openalex.org/W2107932490","https://openalex.org/W2110863682","https://openalex.org/W2112084751","https://openalex.org/W2113306279","https://openalex.org/W2115059097","https://openalex.org/W2115344504","https://openalex.org/W2115552120","https://openalex.org/W2117604923","https://openalex.org/W2117856769","https://openalex.org/W2120130370","https://openalex.org/W2120141122","https://openalex.org/W2123998830","https://openalex.org/W2126136513","https://openalex.org/W2129974599","https://openalex.org/W2130188771","https://openalex.org/W2130924839","https://openalex.org/W2134123172","https://openalex.org/W2134205408","https://openalex.org/W2136613613","https://openalex.org/W2139937511","https://openalex.org/W2139983116","https://openalex.org/W2140740752","https://openalex.org/W2141258570","https://openalex.org/W2145215681","https://openalex.org/W2146586996","https://openalex.org/W2147499591","https://openalex.org/W2152190744","https://openalex.org/W2152629484","https://openalex.org/W2156869047","https://openalex.org/W2158182233","https://openalex.org/W2159062039","https://openalex.org/W2159185400","https://openalex.org/W2162067613","https://openalex.org/W2162137265","https://openalex.org/W2163339050","https://openalex.org/W2165717815","https://openalex.org/W2165793882","https://openalex.org/W2166254397","https://openalex.org/W2167463754","https://openalex.org/W2168342276","https://openalex.org/W2169473323","https://openalex.org/W2272361922","https://openalex.org/W2278874443","https://openalex.org/W2303386823","https://openalex.org/W2313652006","https://openalex.org/W2318942876","https://openalex.org/W2318964100","https://openalex.org/W2318979264","https://openalex.org/W2350768440","https://openalex.org/W2416010609","https://openalex.org/W2416531620","https://openalex.org/W2419235191","https://openalex.org/W2460151152","https://openalex.org/W2466015493","https://openalex.org/W2490389452","https://openalex.org/W2498459717","https://openalex.org/W2531464287","https://openalex.org/W2742410944","https://openalex.org/W2912221368","https://openalex.org/W2952670656","https://openalex.org/W2952798571","https://openalex.org/W2974506996","https://openalex.org/W2977827582","https://openalex.org/W4252246109","https://openalex.org/W4256322168","https://openalex.org/W4292230194","https://openalex.org/W4299955891"],"related_works":["https://openalex.org/W2001839857","https://openalex.org/W2061793997","https://openalex.org/W2334266062","https://openalex.org/W1985118581","https://openalex.org/W2011884857","https://openalex.org/W3215540893","https://openalex.org/W2061801122","https://openalex.org/W1973582972","https://openalex.org/W2467829798","https://openalex.org/W2302810103"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
