{"id":"https://openalex.org/W2327716573","doi":"https://doi.org/10.3181/00379727-182-42342","title":"Inhibition of Leukotriene Actions by the Calcium Channel Blocker, Nisoldipine","display_name":"Inhibition of Leukotriene Actions by the Calcium Channel Blocker, Nisoldipine","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W2327716573","doi":"https://doi.org/10.3181/00379727-182-42342","mag":"2327716573","pmid":"https://pubmed.ncbi.nlm.nih.gov/3012574"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-182-42342","doi":"https://doi.org/10.3181/00379727-182-42342","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-182-42342","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Lefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111651189","display_name":"Atsuo Yanagisawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Yanagisawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":1.0171,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71914095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"3","first_page":"296","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nisoldipine","display_name":"nisoldipine","score":1.0},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9760000109672546},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.8069999814033508},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":1.0},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-contraction","display_name":"vascular smooth muscle contraction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.75},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.39899998903274536},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.49900001287460327},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.7419999837875366},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8629999756813049},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis-inhibition","display_name":"leukotriene biosynthesis inhibition","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2776271655","wikidata":"https://www.wikidata.org/wiki/Q3342150","display_name":"Nisoldipine","level":4,"score":0.9677618741989136},{"id":"https://openalex.org/C2780356492","wikidata":"https://www.wikidata.org/wiki/Q421700","display_name":"Calcium channel blocker","level":3,"score":0.7979096174240112},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5951210260391235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4282296597957611},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.42652708292007446},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.42581507563591003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26759299635887146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17189326882362366},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.13891983032226562}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015737","descriptor_name":"Nisoldipine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-182-42342","doi":"https://doi.org/10.3181/00379727-182-42342","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-182-42342","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:3012574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3012574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3226002114","display_name":"THROMBOXANNE &PAF ANALOGS IN ISCHEMIA-SHOCK","funder_award_id":"R01HL025575","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051558704","https://openalex.org/W31232648","https://openalex.org/W2055587245","https://openalex.org/W2464293646","https://openalex.org/W2040648001","https://openalex.org/W2224790613","https://openalex.org/W1963986249","https://openalex.org/W2064538120","https://openalex.org/W2426528330","https://openalex.org/W2071883756"],"abstract_inverted_index":{"Nisoldipine,":[0,25],"a":[1,6,63,135],"calcium":[2],"channel":[3],"blocker":[4],"having":[5],"highly":[7],"potent":[8],"effect":[9],"on":[10,152],"vascular":[11,153],"smooth":[12,154],"muscle":[13],"relative":[14],"to":[15,20,30,96,134],"cardiac":[16],"muscle,":[17,155],"was":[18],"tested":[19],"determine":[21],"its":[22],"anti-leukotriene":[23,142],"properties.":[24],"at":[26,157],"concentrations":[27,91,104],"from":[28],"1":[29],"300":[31],"ng/ml,":[32],"significantly":[33],"attenuated":[34],"the":[35,74,78,109,112,119],"vasoconstrictor":[36],"effects":[37],"of":[38,67,73,92,105,111,130],"both":[39],"LTC4":[40],"and":[41,49,69,123,156],"LTD4":[42],"in":[43,50],"isolated":[44,51,57,86],"perfused":[45,53,58],"cat":[46,54,87],"coronary":[47,59],"arteries":[48],"Langendorff":[52],"hearts.":[55],"In":[56,85],"arteries,":[60],"nisoldipine":[61,93,106,139,148],"exerted":[62],"greater":[64],"percentage":[65],"inhibition":[66],"LTC4-":[68],"LTD4-induced":[70],"constriction":[71,75],"than":[72],"induced":[76],"by":[77,126],"thromboxane":[79,82],"analog,":[80],"carbocyclic":[81],"A2":[83],"(CTA2).":[84],"lung":[88],"fragments,":[89],"higher":[90,158],"were":[94,132],"required":[95],"inhibit":[97],"leukotriene":[98,114,150,162],"formation":[99,110],"(i.e.,":[100],"10-200":[101],"microM).":[102],"These":[103],"markedly":[107],"inhibited":[108,133],"chemotactic":[113],"(LTB4)":[115],"as":[116,118],"well":[117],"peptide":[120],"leukotrienes":[121,131],"(LTC4":[122],"LTD4)":[124],"stimulated":[125],"A-23187.":[127],"Both":[128],"types":[129],"comparable":[136],"degree.":[137],"Thus,":[138],"has":[140],"significant":[141],"actions.":[143],"At":[144],"normally":[145],"employed":[146],"concentrations,":[147,159],"inhibits":[149,161],"actions":[151],"it":[160],"formation.":[163]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
