{"id":"https://openalex.org/W2327423182","doi":"https://doi.org/10.1021/jm400062r","title":"Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors","display_name":"Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors","publication_year":2013,"publication_date":"2013-04-09","ids":{"openalex":"https://openalex.org/W2327423182","doi":"https://doi.org/10.1021/jm400062r","mag":"2327423182","pmid":"https://pubmed.ncbi.nlm.nih.gov/23570561"},"language":"en","primary_location":{"id":"doi:10.1021/jm400062r","doi":"https://doi.org/10.1021/jm400062r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm400062r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090372748","display_name":"Yan Bing Yin","orcid":"https://orcid.org/0000-0001-5481-1114","observed_orcids":["https://orcid.org/0000-0001-5481-1114"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Yin","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412926","display_name":"Lin Li","orcid":"https://orcid.org/0000-0003-0426-6546","observed_orcids":["https://orcid.org/0000-0003-0426-6546","https://orcid.org/0009-0006-4540-8271","https://orcid.org/0000-0001-7240-8150"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Lin","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076699836","display_name":"Claudia H. Ruiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Ruiz","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100862873","display_name":"Susan Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Khan","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041449809","display_name":"Michael D. Cameron","orcid":"https://orcid.org/0000-0003-3154-4775","observed_orcids":["https://orcid.org/0000-0003-3154-4775"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Cameron","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057474722","display_name":"Wayne M. Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne Grant","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033402675","display_name":"Jennifer R. Pocas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Pocas","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071000091","display_name":"Nibal Eid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nibal Eid","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083178786","display_name":"HaJeung Park","orcid":"https://orcid.org/0000-0003-4898-7919","observed_orcids":["https://orcid.org/0000-0003-4898-7919"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HaJeung Park","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016435962","display_name":"Thomas Schr\u00f6ter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schr\u00f6ter","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004405545","display_name":"Philip V. LoGrasso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip V. LoGrasso","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101625901","display_name":"Yangbo Feng","orcid":"https://orcid.org/0000-0002-5894-9476","observed_orcids":["https://orcid.org/0000-0002-5894-9476"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yangbo Feng","raw_affiliation_strings":["Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal\rChemistry; \u2021Discovery Biology; \u221eCrystallography/Modeling Facility; \u00a7Drug Metabolism and Pharmacokinetics, Translational\rResearch Institute, and \u00a5Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, 130\rScripps Way, #2A1, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004405545","https://openalex.org/A5101625901"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6367,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.91287682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56","issue":"9","first_page":"3568","last_page":"3581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-kinase-inhibitor","display_name":"ROCK inhibitor","score":0.8889999985694885},{"id":"https://openalex.org/keywords/urea-derivatives","display_name":"urea derivatives","score":0.902999997138977},{"id":"https://openalex.org/keywords/rhoa-rock-signaling-pathway","display_name":"RhoA/ROCK signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/myosin-light-chain-phosphorylation","display_name":"myosin light chain phosphorylation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/stress-fiber-formation","display_name":"stress fiber formation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8050000071525574},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8059999942779541},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.921999990940094},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-metabolism-and-pharmacokinetics","display_name":"drug metabolism and pharmacokinetics","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.9106849431991577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8242591023445129},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7483373880386353},{"id":"https://openalex.org/C2779331819","wikidata":"https://www.wikidata.org/wiki/Q18034313","display_name":"ROCK2","level":4,"score":0.693334698677063},{"id":"https://openalex.org/C201800478","wikidata":"https://www.wikidata.org/wiki/Q24721770","display_name":"Rho-associated protein kinase","level":3,"score":0.6894687414169312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5667305588722229},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5506394505500793},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.44380098581314087},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4195922315120697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34765326976776123},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.34609419107437134},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2001059353351593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07510510087013245},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D060326","descriptor_name":"Chemistry Techniques, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm400062r","doi":"https://doi.org/10.1021/jm400062r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm400062r","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:23570561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23570561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W4770467","https://openalex.org/W1579639018","https://openalex.org/W1597787921","https://openalex.org/W1971717325","https://openalex.org/W1972275157","https://openalex.org/W1975064033","https://openalex.org/W1979495469","https://openalex.org/W1998299358","https://openalex.org/W2004492415","https://openalex.org/W2008029604","https://openalex.org/W2011379117","https://openalex.org/W2013412560","https://openalex.org/W2023659538","https://openalex.org/W2037922684","https://openalex.org/W2043955847","https://openalex.org/W2049991415","https://openalex.org/W2053528730","https://openalex.org/W2060999873","https://openalex.org/W2067032104","https://openalex.org/W2076270411","https://openalex.org/W2079962468","https://openalex.org/W2084722299","https://openalex.org/W2085002639","https://openalex.org/W2093163741","https://openalex.org/W2096646722","https://openalex.org/W2096730217","https://openalex.org/W2111807830","https://openalex.org/W2112451265","https://openalex.org/W2128017045","https://openalex.org/W2130589134","https://openalex.org/W2133411449","https://openalex.org/W2154064012","https://openalex.org/W2158881790","https://openalex.org/W4236841553","https://openalex.org/W4245177517"],"related_works":["https://openalex.org/W2076270411","https://openalex.org/W2053528730","https://openalex.org/W4410202308","https://openalex.org/W3202122049","https://openalex.org/W2170896502","https://openalex.org/W2083090516","https://openalex.org/W3165216305","https://openalex.org/W2037922684","https://openalex.org/W2763031166","https://openalex.org/W2014782107"],"abstract_inverted_index":{"RhoA":[0],"and":[1,10,44,67,70,118,121,129],"its":[2],"downstream":[3],"effector":[4],"ROCK":[5,53,85,131],"mediate":[6],"stress":[7],"fiber":[8],"formation":[9],"cell":[11],"contraction":[12],"through":[13],"their":[14],"effects":[15,75],"on":[16],"the":[17,26],"phosphorylation":[18],"of":[19,25],"myosin":[20],"light":[21],"chain":[22],"(MLC).":[23],"Inhibition":[24],"RhoA/ROCK":[27],"pathway":[28],"has":[29],"proven":[30],"to":[31,102],"be":[32],"a":[33,104],"promising":[34],"strategy":[35],"for":[36,107],"several":[37],"indications":[38],"such":[39],"as":[40,55,92],"cardiovascular":[41],"disease,":[42],"glaucoma,":[43,103],"inflammatory":[45],"disease.":[46],"In":[47],"2010,":[48],"our":[49],"group":[50],"reported":[51],"urea-based":[52,109],"inhibitors":[54,86,132],"potential":[56,89],"antiglaucoma":[57],"agents.":[58],"These":[59],"compounds":[60],"showed":[61],"potent":[62],"IC50":[63],"values":[64],"in":[65,76,100,119,122,135],"enzymatic":[66],"cell-based":[68],"assays":[69],"significant":[71],"intraocular":[72],"pressure":[73],"(IOP)-lowering":[74],"rats":[77],"(\u223c7":[78],"mmHg).":[79],"(22)":[80],"To":[81],"develop":[82],"more":[83],"advanced":[84],"targeting":[87],"various":[88,134],"applications":[90],"(such":[91],"myocardial":[93],"infarction,":[94],"erectile":[95],"dysfunction,":[96],"multiple":[97],"sclerosis,":[98],"etc.)":[99],"addition":[101],"thorough":[105],"SAR":[106],"this":[108],"scaffold":[110],"was":[111],"studied.":[112],"The":[113],"detailed":[114],"optimization":[115],"process,":[116],"counter-screening,":[117],"vitro":[120],"vivo":[123,136],"DMPK":[124],"studies":[125],"are":[126],"discussed.":[127],"Potent":[128],"selective":[130],"with":[133],"pharmacokinetic":[137],"properties":[138],"were":[139],"discovered.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
