{"id":"https://openalex.org/W2327245331","doi":"https://doi.org/10.1056/nejm199612053352303","title":"The DCC Protein and Prognosis in Colorectal Cancer","display_name":"The DCC Protein and Prognosis in Colorectal Cancer","publication_year":1996,"publication_date":"1996-12-05","ids":{"openalex":"https://openalex.org/W2327245331","doi":"https://doi.org/10.1056/nejm199612053352303","mag":"2327245331","pmid":"https://pubmed.ncbi.nlm.nih.gov/8929264"},"language":"en","primary_location":{"id":"doi:10.1056/nejm199612053352303","doi":"https://doi.org/10.1056/nejm199612053352303","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199612053352303","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199612053352303?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199612053352303?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025906534","display_name":"David Shibata","orcid":"https://orcid.org/0000-0002-5670-423X","observed_orcids":["https://orcid.org/0000-0002-5670-423X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Shibata","raw_affiliation_strings":["Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA","Laboratory of Cancer Biology, Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, New England Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Laboratory of Cancer Biology, Department of Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A. Reale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Reale","raw_affiliation_strings":["Section of Medical Oncology, Yale University School of Medicine, New Haven, Conn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Medical Oncology, Yale University School of Medicine, New Haven, Conn","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057084111","display_name":"Philip T. Lavin","orcid":"https://orcid.org/0000-0002-8381-0740","observed_orcids":["https://orcid.org/0000-0002-8381-0740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Lavin","raw_affiliation_strings":["Boston Biostatistics Research Foundation, Framingham, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Biostatistics Research Foundation, Framingham, Mass","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109181139","display_name":"Mark L. Silverman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289019353","display_name":"Lahey Hospital and Medical Center","ror":"https://ror.org/03mbq3y29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289019353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Silverman","raw_affiliation_strings":["Department of Pathology, Lahey\u2013Hitchcock Medical Center, Burlington, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Lahey\u2013Hitchcock Medical Center, Burlington, Mass","institution_ids":["https://openalex.org/I1289019353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075652120","display_name":"Eric R. Fearon","orcid":"https://orcid.org/0000-0003-2867-3971","observed_orcids":["https://orcid.org/0000-0003-2867-3971"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric R. Fearon","raw_affiliation_strings":["Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112160647","display_name":"Glenn D. Steele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Steele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024610298","display_name":"John Milburn Jessup","orcid":"https://orcid.org/0000-0002-6884-1872","observed_orcids":["https://orcid.org/0000-0002-6884-1872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Jessup","raw_affiliation_strings":["Laboratory of Cancer Biology, Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Department of Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071763026","display_name":"Massimo F. Loda","orcid":"https://orcid.org/0000-0001-9674-8379","observed_orcids":["https://orcid.org/0000-0001-9674-8379"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massimo Loda","raw_affiliation_strings":["Department of Pathology, New England Deaconess Hospital, Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New England Deaconess Hospital, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109983508","display_name":"Ian C. Summerhayes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian C. Summerhayes","raw_affiliation_strings":["Laboratory of Cancer Biology, Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology, Department of Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":16.8412,"has_fulltext":true,"cited_by_count":308,"citation_normalized_percentile":{"value":0.99472231,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"335","issue":"23","first_page":"1727","last_page":"1732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.8690999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6840000152587891},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7210000157356262},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8725955486297607},{"id":"https://openalex.org/C129642508","wikidata":"https://www.wikidata.org/wiki/Q14905674","display_name":"Deleted in Colorectal Cancer","level":4,"score":0.8651758432388306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7677348852157593},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5895103216171265},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5258299112319946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4896862804889679},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4498235583305359},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.4326592981815338},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43121200799942017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3969593048095703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22537550330162048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1717810034751892}],"mesh":[{"descriptor_ui":"D000075389","descriptor_name":"DCC Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075389","descriptor_name":"DCC Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075389","descriptor_name":"DCC Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016163","descriptor_name":"Genes, DCC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016163","descriptor_name":"Genes, DCC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016163","descriptor_name":"Genes, DCC","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm199612053352303","doi":"https://doi.org/10.1056/nejm199612053352303","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199612053352303","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199612053352303?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:8929264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8929264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1056/nejm199612053352303","doi":"https://doi.org/10.1056/nejm199612053352303","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199612053352303","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199612053352303?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2106739254","display_name":null,"funder_award_id":"CA-44704","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2327245331.pdf","grobid_xml":"https://content.openalex.org/works/W2327245331.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1246919061","https://openalex.org/W1519595222","https://openalex.org/W1541991770","https://openalex.org/W1546856290","https://openalex.org/W1573604220","https://openalex.org/W1580788756","https://openalex.org/W1826292325","https://openalex.org/W1840481440","https://openalex.org/W1962875322","https://openalex.org/W1979300931","https://openalex.org/W1980847511","https://openalex.org/W1982329083","https://openalex.org/W1990055603","https://openalex.org/W1996449685","https://openalex.org/W2000309947","https://openalex.org/W2000400293","https://openalex.org/W2008477088","https://openalex.org/W2019384026","https://openalex.org/W2024732305","https://openalex.org/W2032930680","https://openalex.org/W2044069822","https://openalex.org/W2058393879","https://openalex.org/W2058907961","https://openalex.org/W2082451710","https://openalex.org/W2090865074","https://openalex.org/W2100522747","https://openalex.org/W2110042773","https://openalex.org/W2129502037","https://openalex.org/W2131102224","https://openalex.org/W2132761235","https://openalex.org/W2135398482","https://openalex.org/W2135418233","https://openalex.org/W2145728517","https://openalex.org/W2158487071","https://openalex.org/W2159848047","https://openalex.org/W2207795912","https://openalex.org/W2341601510","https://openalex.org/W2342099948","https://openalex.org/W2411355855","https://openalex.org/W2413460136","https://openalex.org/W2414239327","https://openalex.org/W2441608358","https://openalex.org/W2461130974","https://openalex.org/W3041047318","https://openalex.org/W3147894994","https://openalex.org/W4241885007","https://openalex.org/W4255986575"],"related_works":["https://openalex.org/W2371430861","https://openalex.org/W1519595222","https://openalex.org/W2186037387","https://openalex.org/W2118326351","https://openalex.org/W2358661390","https://openalex.org/W2474030663","https://openalex.org/W24886319","https://openalex.org/W2075977000","https://openalex.org/W1998801792","https://openalex.org/W2090650254"],"abstract_inverted_index":{"BACKGROUND:":[0],"Allelic":[1],"loss":[2,25],"of":[3,45,62,98,103,109,198,203,223],"chromosome":[4],"18q":[5],"predicts":[6],"a":[7,38,53,112,178,201],"poor":[8],"outcome":[9],"in":[10,33,49,56,67,119,146,181,220],"patients":[11,72,129,147,159,182,204],"with":[12,73,130,148,160,183,205],"stage":[13,76,121,124,131,161,184,187,192,210],"II":[14,77,122,132,185,193],"colorectal":[15,34,57,80,126,189,194],"cancer.":[16,190],"Although":[17],"the":[18,30,43,46,138,151,164,196],"specific":[19],"gene":[20,36],"inactivated":[21],"by":[22],"this":[23,221],"allelic":[24],"has":[26],"not":[27],"been":[28],"elucidated,":[29],"DCC":[31,47,63,110,176,199],"(deleted":[32],"cancer)":[35],"is":[37,52,177],"candidate.":[39],"We":[40],"investigated":[41],"whether":[42],"expression":[44,61,108],"protein":[48],"tumor":[50,95,99],"cells":[51],"prognostic":[54,179],"marker":[55,180],"carcinoma.":[58],"METHODS:":[59],"The":[60,82,107],"was":[64,86,111,142,154],"evaluated":[65],"immunohistochemically":[66],"132":[68],"paraffin-embedded":[69],"samples":[70],"from":[71],"curatively":[74],"resected":[75],"and":[78,101,123,171],"III":[79,125,162,188,211],"carcinomas.":[81,127],"Cox":[83],"proportional-hazards":[84],"model":[85],"used":[87],"to":[88],"adjust":[89],"for":[90,117],"covariates":[91],"including":[92],"age,":[93],"sex,":[94],"site,":[96],"degree":[97],"differentiation,":[100],"use":[102],"adjuvant":[104],"therapy.":[105],"RESULTS:":[106],"strong":[113],"positive":[114],"predictive":[115],"factor":[116],"survival":[118,140,152,166],"both":[120],"In":[128,158,191],"disease":[133],"whose":[134],"tumors":[135],"expressed":[136],"DCC,":[137],"five-year":[139],"rate":[141,153],"94.3":[143],"percent,":[144],"whereas":[145],"DCC-negative":[149],"tumors,":[150],"61.6":[155],"percent":[156,170,173],"(P<0.001).":[157],"disease,":[163],"respective":[165],"rates":[167],"were":[168],"59.3":[169],"33.2":[172],"(P=0.03).":[174],"CONCLUSIONS:":[175],"or":[186],"carcinomas,":[195],"absence":[197],"identifies":[200],"subgroup":[202],"lesions":[206],"that":[207],"behave":[208],"like":[209],"cancers.":[212],"These":[213],"findings":[214],"may":[215],"thus":[216],"have":[217],"therapeutic":[218],"implications":[219],"group":[222],"patients.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
