{"id":"https://openalex.org/W2326778709","doi":"https://doi.org/10.3109/14659891.2015.1045047","title":"Methylphenidate substitution for methamphetamine addiction and implications for future randomized clinical trials: a unique case series","display_name":"Methylphenidate substitution for methamphetamine addiction and implications for future randomized clinical trials: a unique case series","publication_year":2015,"publication_date":"2015-11-23","ids":{"openalex":"https://openalex.org/W2326778709","doi":"https://doi.org/10.3109/14659891.2015.1045047","mag":"2326778709"},"language":"en","primary_location":{"id":"doi:10.3109/14659891.2015.1045047","doi":"https://doi.org/10.3109/14659891.2015.1045047","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14659891.2015.1045047","pdf_url":null,"source":{"id":"https://openalex.org/S198818534","display_name":"Journal of Substance Use","issn_l":"1465-9891","issn":["1465-9891","1475-9942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Substance Use","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057465102","display_name":"Jakub Mina\u0159\u00edk","orcid":"https://orcid.org/0000-0003-0472-5386","observed_orcids":["https://orcid.org/0000-0003-0472-5386"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jakub Mina\u0159\u00edk","raw_affiliation_strings":["Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, ; SANANIM, Prague, Czech Republic, and","Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic,","SANANIM, Prague, Czech Republic, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, ; SANANIM, Prague, Czech Republic, and","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic,","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"SANANIM, Prague, Czech Republic, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055490965","display_name":"Roman Gabrhel\u00edk","orcid":"https://orcid.org/0000-0002-7672-3753","observed_orcids":["https://orcid.org/0000-0002-7672-3753"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Roman Gabrhel\u00edk","raw_affiliation_strings":["Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057442519","display_name":"Robert J Malcolm","orcid":"https://orcid.org/0000-0001-5148-3928","observed_orcids":["https://orcid.org/0000-0001-5148-3928"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Malcolm","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053708281","display_name":"Amalie Pavlovsk\u00e1","orcid":"https://orcid.org/0000-0002-4360-9356","observed_orcids":["https://orcid.org/0000-0002-4360-9356"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Amalie Pavlovsk\u00e1","raw_affiliation_strings":["Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, ; SANANIM, Prague, Czech Republic, and","Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic,","SANANIM, Prague, Czech Republic, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic, ; SANANIM, Prague, Czech Republic, and","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Department of Addictology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic,","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"SANANIM, Prague, Czech Republic, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057511354","display_name":"Peter M. Miller","orcid":"https://orcid.org/0000-0002-6896-5437","observed_orcids":["https://orcid.org/0000-0002-6896-5437"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Miller","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055490965"],"corresponding_institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"],"apc_list":null,"apc_paid":null,"fwci":0.5013,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65520909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"21","issue":"4","first_page":"435","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine-dependence","display_name":"methamphetamine dependence","score":0.8330000042915344},{"id":"https://openalex.org/keywords/treatment-engagement","display_name":"treatment engagement","score":0.5429999828338623},{"id":"https://openalex.org/keywords/co-occurring-psychiatric-disorders","display_name":"co-occurring psychiatric disorders","score":0.8259999752044678},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.7239999771118164},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.7379691004753113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6761094331741333},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.5845243334770203},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.5755593776702881},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.5597211122512817},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.516523540019989},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.48528429865837097},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4835672080516815},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3672887086868286},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3384970426559448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22441014647483826},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.18389612436294556}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/14659891.2015.1045047","doi":"https://doi.org/10.3109/14659891.2015.1045047","is_oa":false,"landing_page_url":"https://doi.org/10.3109/14659891.2015.1045047","pdf_url":null,"source":{"id":"https://openalex.org/S198818534","display_name":"Journal of Substance Use","issn_l":"1465-9891","issn":["1465-9891","1475-9942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Substance Use","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1510604256","https://openalex.org/W1581899689","https://openalex.org/W1871254996","https://openalex.org/W1949947453","https://openalex.org/W1968445289","https://openalex.org/W2003544167","https://openalex.org/W2003815730","https://openalex.org/W2020457020","https://openalex.org/W2050123998","https://openalex.org/W2086590412","https://openalex.org/W2088775708","https://openalex.org/W2104563699","https://openalex.org/W2117052590","https://openalex.org/W2123906112","https://openalex.org/W2142942681","https://openalex.org/W2145278957","https://openalex.org/W2155613326","https://openalex.org/W4253804374"],"related_works":["https://openalex.org/W1871254996","https://openalex.org/W7039695089","https://openalex.org/W1581899689","https://openalex.org/W3119114014","https://openalex.org/W3088697057","https://openalex.org/W2983572746","https://openalex.org/W2069148420","https://openalex.org/W2314855495","https://openalex.org/W2117052590","https://openalex.org/W1549793801"],"abstract_inverted_index":{"Background:":[0],"Methamphetamine":[1],"Use":[2],"Disorders":[3],"(MUD)":[4],"pharmacotherapy":[5,229],"research":[6],"yields":[7],"contradictory":[8],"results.Objective:":[9],"Our":[10,161,207],"objective":[11],"was":[12,73,147,201],"to":[13,111,129,224,237],"identify":[14],"treatment":[15,67,72,99,156,195],"outcome":[16],"features":[17],"of":[18,21,44,71,91,116,140,216,221,226,230],"intravenous":[19,46,134],"users":[20,115],"methamphetamine":[22,117],"(IUM)":[23],"treated":[24,51,177],"by":[25,149],"one":[26,150],"healthcare":[27],"provider":[28],"using":[29],"stable":[30],"methylphenidate":[31],"(MPH)":[32,227],"substitution":[33],"protocols":[34],"over":[35],"an":[36],"extended":[37],"interval.Method:":[38],"We":[39],"retrospectively":[40],"examined":[41],"a":[42,63,103],"database":[43],"all":[45],"MUD":[47,174],"cases":[48,85],"(24":[49],"patients)":[50],"with":[52,173,180,184],"short":[53,181],"acting":[54,182],"MPH":[55,183],"and":[56,60,105,120,137,167],"psychotherapy":[57],"between":[58],"2007":[59],"2013":[61],"in":[62,80,83,98,171,194,196],"single":[64],"outpatient":[65],"addiction":[66],"facility.Results:":[68],"Mean":[69],"duration":[70],"8":[74],"months":[75,179],"(<1\u201331":[76],"months).":[77],"Treatment":[78],"resulted":[79],"full":[81],"abstinence":[82],"10":[84],"\u2013":[86],"maintained":[87],"until":[88],"the":[89,92,197,210,213],"end":[90],"observation":[93],"period.":[94],"Patients":[95],"who":[96,152,175],"stayed":[97],"for":[100,157,203,212],"more":[101,109],"than":[102],"month":[104],"remained":[106],"abstinent":[107],"were":[108,176,189],"likely":[110],"be":[112],"regular":[113],"pattern":[114],"(MA),":[118],"female":[119],"characterized":[121],"as":[122],"having":[123],"co-occurring":[124],"psychiatric":[125],"disorders":[126],"that":[127],"responded":[128],"treatment.":[130],"These":[131],"patients":[132,172,192],"discontinued":[133],"MA":[135,231],"use":[136,222],"demonstrated":[138],"stabilization":[139],"their":[141],"health":[142],"conditions.":[143],"One":[144],"adverse":[145],"effect":[146],"reported":[148],"patient":[151],"required":[153],"emergency":[154],"department":[155],"accidental":[158],"alcohol":[159],"poisoning.Conclusion:":[160],"clinical":[162,205,242],"series":[163],"indicated":[164,209],"favorable":[165],"outcomes":[166],"low":[168],"dropout":[169],"rates":[170],"several":[178],"individualized":[185],"dosing.":[186],"Adverse":[187],"effects":[188],"rare.":[190],"Keeping":[191],"engaged":[193],"first":[198],"four":[199],"weeks":[200],"critical":[202],"good":[204],"outcomes.":[206],"findings":[208],"need":[211],"possible":[214],"application":[215],"pre-selective":[217],"criteria":[218],"regarding":[219],"patterns":[220],"prior":[223],"initiation":[225],"agonist":[228],"dependence.":[232],"Prospective":[233],"studies":[234],"are":[235],"needed":[236],"confirm":[238],"or":[239],"reject":[240],"these":[241],"observations.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}