{"id":"https://openalex.org/W2326087522","doi":"https://doi.org/10.1093/jnen/62.2.195","title":"Reversal of Thiamine Deficiency-Induced Neurodegeneration","display_name":"Reversal of Thiamine Deficiency-Induced Neurodegeneration","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2326087522","doi":"https://doi.org/10.1093/jnen/62.2.195","mag":"2326087522","pmid":"https://pubmed.ncbi.nlm.nih.gov/12578229"},"language":"en","primary_location":{"id":"doi:10.1093/jnen/62.2.195","doi":"https://doi.org/10.1093/jnen/62.2.195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/62.2.195","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052936351","display_name":"Zunji Ke","orcid":"https://orcid.org/0000-0003-4038-2456","observed_orcids":["https://orcid.org/0000-0003-4038-2456"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210117944","display_name":"Burke Medical Research Institute","ror":"https://ror.org/02sp1z620","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117944"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zun-Ji Ke","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York, USA","Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944"]},{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113696578","display_name":"Lorraine A. DeGiorgio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210117944","display_name":"Burke Medical Research Institute","ror":"https://ror.org/02sp1z620","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117944"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine A. Degiorgio","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046913023","display_name":"Bruce T. Volpe","orcid":"https://orcid.org/0000-0002-1098-1848","observed_orcids":["https://orcid.org/0000-0002-1098-1848"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210117944","display_name":"Burke Medical Research Institute","ror":"https://ror.org/02sp1z620","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117944"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce T. Volpe","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034019470","display_name":"Gary E. Gibson","orcid":"https://orcid.org/0000-0003-2549-2876","observed_orcids":["https://orcid.org/0000-0003-2549-2876"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210117944","display_name":"Burke Medical Research Institute","ror":"https://ror.org/02sp1z620","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117944"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary E. Gibson","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University at Burke Medical Research Institute, White Plains, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052936351"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210117944","https://openalex.org/I4387153466"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":2.0999,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.86569938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"62","issue":"2","first_page":"195","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiamine-deficiency","display_name":"thiamine deficiency","score":1.0},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.656000018119812},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/thiamine-supplementation","display_name":"thiamine supplementation","score":0.843999981880188},{"id":"https://openalex.org/keywords/oxidative-metabolism","display_name":"oxidative metabolism","score":0.5540000200271606},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/thiamine-dependent-enzymes","display_name":"thiamine-dependent enzymes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neurodegenerative-disease-models","display_name":"neurodegenerative disease models","score":0.625}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9163378477096558},{"id":"https://openalex.org/C2776203871","wikidata":"https://www.wikidata.org/wiki/Q83187","display_name":"Thiamine","level":2,"score":0.9034045934677124},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7492132186889648},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.6287001967430115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45690715312957764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.446724534034729},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.43992921710014343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4227268695831299},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38068610429763794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3541119396686554},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2407841980457306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23455333709716797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.209333598613739},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0988120436668396},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013831","descriptor_name":"Thiamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013831","descriptor_name":"Thiamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013832","descriptor_name":"Thiamine Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013832","descriptor_name":"Thiamine Deficiency","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013832","descriptor_name":"Thiamine Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnen/62.2.195","doi":"https://doi.org/10.1093/jnen/62.2.195","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnen/62.2.195","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:12578229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12578229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4287918531","display_name":"Age/Nutrition/Genes in Models of Psychiatric Disorders","funder_award_id":"R01AG014600","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1504816243","https://openalex.org/W1522048223","https://openalex.org/W1964466147","https://openalex.org/W1970941517","https://openalex.org/W1980007375","https://openalex.org/W1980276379","https://openalex.org/W1983682043","https://openalex.org/W1987674477","https://openalex.org/W1989462226","https://openalex.org/W1997923870","https://openalex.org/W2000420411","https://openalex.org/W2002616987","https://openalex.org/W2007628454","https://openalex.org/W2008429547","https://openalex.org/W2012710118","https://openalex.org/W2020297346","https://openalex.org/W2020941408","https://openalex.org/W2028546937","https://openalex.org/W2030660501","https://openalex.org/W2030848377","https://openalex.org/W2031082537","https://openalex.org/W2031226563","https://openalex.org/W2041158284","https://openalex.org/W2043915507","https://openalex.org/W2047862393","https://openalex.org/W2070746053","https://openalex.org/W2076496035","https://openalex.org/W2079520843","https://openalex.org/W2081319561","https://openalex.org/W2083617962","https://openalex.org/W2088730075","https://openalex.org/W2090257252","https://openalex.org/W2125858469","https://openalex.org/W2138152051","https://openalex.org/W2143335690","https://openalex.org/W2158496649","https://openalex.org/W2169725606","https://openalex.org/W2229023772","https://openalex.org/W2238116286","https://openalex.org/W2291459728","https://openalex.org/W2410599971","https://openalex.org/W4285719527","https://openalex.org/W7074100618"],"related_works":["https://openalex.org/W1970941517","https://openalex.org/W2023031512","https://openalex.org/W2017342519","https://openalex.org/W2793979821","https://openalex.org/W2753270991","https://openalex.org/W2291459728","https://openalex.org/W2045559921","https://openalex.org/W3003743719","https://openalex.org/W3176902129","https://openalex.org/W2171605423"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1],"are":[2],"characterized":[3],"by":[4,75,83,86],"abnormalities":[5],"in":[6,42,48,179,198],"oxidative":[7,27],"processes,":[8],"region-selective":[9],"neuron":[10,57,73,104],"loss,":[11],"and":[12,29,44,69,85,132,149,164,183,205],"diminished":[13],"thiamine-dependent":[14],"enzymes.":[15],"Thiamine":[16,124,142],"deficiency":[17],"(TD)":[18],"diminishes":[19],"thiamine":[20,118],"dependent":[21],"enzymes,":[22],"alters":[23],"mitochondrial":[24],"function,":[25],"impairs":[26],"metabolism,":[28],"causes":[30],"selective":[31],"neuronal":[32,130,162,199,202],"death.":[33],"In":[34],"mice,":[35],"the":[36,49,108,194],"time":[37],"course":[38],"of":[39,66,79,110,122,134,166],"TD-induced":[40],"changes":[41,140],"neurons":[43],"microglia":[45,80,93,168,184],"were":[46,94],"determined":[47],"brain":[50],"region":[51],"most":[52],"sensitive":[53],"to":[54,71,161,201],"TD.":[55,123],"Significant":[56],"loss":[58,74,131],"(29%)":[59],"occurred":[60],"after":[61,119],"8":[62],"or":[63],"9":[64],"days":[65],"TD":[67,111,176],"(TD8-9)":[68],"increased":[70,81,100],"90%":[72],"TD10-11.":[76,153],"The":[77,172],"number":[78],"16%":[82],"TD8":[84,127],"nearly":[87],"400%":[88],"on":[89,126,147,152,170],"TD11.":[90],"Hemeoxygenase-1":[91],"(HO-1)-positive":[92],"not":[95],"detectable":[96],"at":[97],"TD8,":[98],"yet":[99],"dramatically":[101],"coincident":[102],"with":[103],"loss.":[105],"To":[106],"test":[107],"duration":[109],"critical":[112],"for":[113,192],"irrevocable":[114],"changes,":[115],"mice":[116],"received":[117],"various":[120],"durations":[121],"administration":[125],"blocked":[128],"further":[129],"induction":[133,165],"HO-1-positive":[135,167],"microglia,":[136],"whereas":[137],"other":[138],"microglial":[139,207],"persisted.":[141],"only":[143],"partially":[144],"reversed":[145],"effects":[146],"TD9,":[148],"was":[150],"ineffective":[151],"These":[154],"studies":[155],"indicate":[156,174],"that":[157,175],"irreversible":[158],"steps":[159],"leading":[160],"death":[163,203],"occur":[169],"TD9.":[171],"results":[173],"induces":[177],"alterations":[178],"neurons.":[180],"endothelial":[181],"cells,":[182],"contemporaneously.":[185],"This":[186],"model":[187],"provides":[188],"a":[189],"unique":[190],"paradigm":[191],"elucidating":[193],"molecular":[195],"mechanisms":[196],"involved":[197],"commitment":[200],"cascades":[204],"contributory":[206],"activity.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}