{"id":"https://openalex.org/W2325918953","doi":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","title":"Pepsin is nitrated in the stomach acquiring anti-ulcerogenic activity: a novel nitrating pathway involving dietary nitrite, gut microbiota and gastric proteins","display_name":"Pepsin is nitrated in the stomach acquiring anti-ulcerogenic activity: a novel nitrating pathway involving dietary nitrite, gut microbiota and gastric proteins","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W2325918953","doi":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","mag":"2325918953"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2012.08.545","doi":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075543018","display_name":"B\u00e1rbara S. Rocha","orcid":"https://orcid.org/0000-0002-0697-8806","observed_orcids":["https://orcid.org/0000-0002-0697-8806"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"B.S. Rocha\u204e","raw_affiliation_strings":["University of Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017671512","display_name":"Bruno Gago","orcid":"https://orcid.org/0000-0002-0082-3256","observed_orcids":["https://orcid.org/0000-0002-0082-3256"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"B. Gago","raw_affiliation_strings":["University of Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003921163","display_name":"Rui M. Barbosa","orcid":"https://orcid.org/0000-0002-1604-6324","observed_orcids":["https://orcid.org/0000-0002-1604-6324"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"R.M. Barbosa","raw_affiliation_strings":["University of Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013543425","display_name":"Jon O. Lundberg","orcid":"https://orcid.org/0000-0002-0174-5210","observed_orcids":["https://orcid.org/0000-0002-0174-5210"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J.O. Lundberg","raw_affiliation_strings":["Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Radi","raw_affiliation_strings":["Facultad de Medicina and Center for Free Radical and Biomedical Research, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina and Center for Free Radical and Biomedical Research, Montevideo, Uruguay","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090186962","display_name":"Jo\u00e3o A.N. Laranjinha","orcid":"https://orcid.org/0000-0003-4370-5177","observed_orcids":["https://orcid.org/0000-0003-4370-5177"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"J. Laranjinha","raw_affiliation_strings":["University of Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27391886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":null,"first_page":"S60","last_page":"S60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.3707999885082245,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.3707999885082245,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.17790000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pepsin","display_name":"pepsin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nitration","display_name":"nitration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dietary-nitrite","display_name":"dietary nitrite","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9039999842643738},{"id":"https://openalex.org/keywords/antiulcer-activity","display_name":"antiulcer activity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.5659999847412109},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.8318343162536621},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.7542307376861572},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.695492148399353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.611336886882782},{"id":"https://openalex.org/C2910772780","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Dietary Nitrate","level":4,"score":0.47209852933883667},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37125617265701294},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33643069863319397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3262571692466736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23784604668617249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19705212116241455},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12267094850540161},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.12199869751930237},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2012.08.545","doi":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2012.08.545","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046160293","https://openalex.org/W2330818135","https://openalex.org/W2240211443","https://openalex.org/W4410880413","https://openalex.org/W2016140696","https://openalex.org/W4399279632","https://openalex.org/W2474350614","https://openalex.org/W2036475733","https://openalex.org/W2080921361","https://openalex.org/W2404300400"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}