{"id":"https://openalex.org/W2325910314","doi":null,"title":"Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta.","display_name":"Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta.","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W2325910314","mag":"2325910314","pmid":"https://pubmed.ncbi.nlm.nih.gov/16173240"},"language":"en","primary_location":{"id":"pmid:16173240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16173240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069235693","display_name":"Mari Ainola","orcid":"https://orcid.org/0000-0003-2853-5851","observed_orcids":["https://orcid.org/0000-0003-2853-5851"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M M Ainola","raw_affiliation_strings":["Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Anatomy, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048208320","display_name":"Jami Mandelin","orcid":"https://orcid.org/0000-0001-7686-8752","observed_orcids":["https://orcid.org/0000-0001-7686-8752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Mandelin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103409135","display_name":"Mikko Liljestr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P Liljestr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063733566","display_name":"Tian\u2010Fang Li","orcid":"https://orcid.org/0000-0002-9963-9976","observed_orcids":["https://orcid.org/0000-0002-9963-9976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T F Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042103616","display_name":"Mika Hukkanen","orcid":"https://orcid.org/0000-0001-9687-9571","observed_orcids":["https://orcid.org/0000-0001-9687-9571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M V J Hukkanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109209802","display_name":"Yrj\u00f6 Tapio Konttinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y T Konttinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5373,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.92708151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"5","first_page":"644","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pannus","display_name":"pannus","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.828000009059906},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9430000185966492},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cartilage-erosion","display_name":"cartilage erosion","score":0.7570000290870667},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.843999981880188},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mmp-14","display_name":"MMP-14","score":0.9829999804496765},{"id":"https://openalex.org/keywords/proteoglycan-matrix","display_name":"proteoglycan matrix","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777746085","wikidata":"https://www.wikidata.org/wiki/Q1506304","display_name":"Pannus","level":3,"score":0.9781492948532104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7887149453163147},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7548782825469971},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6960129737854004},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6693738698959351},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4568728506565094},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44992977380752563},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4419521689414978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3678748607635498},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.22607886791229248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20820045471191406},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0910581648349762}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002357","descriptor_name":"Cartilage Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013585","descriptor_name":"Synovitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053504","descriptor_name":"Matrix Metalloproteinases, Membrane-Associated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16173240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16173240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2325910314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16173240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W156759583","https://openalex.org/W1491598928","https://openalex.org/W1554372034","https://openalex.org/W1640167750","https://openalex.org/W1973808165","https://openalex.org/W1975523013","https://openalex.org/W1984837363","https://openalex.org/W1995248099","https://openalex.org/W1995721306","https://openalex.org/W1996582404","https://openalex.org/W2003284223","https://openalex.org/W2012419795","https://openalex.org/W2023560282","https://openalex.org/W2024146240","https://openalex.org/W2027275036","https://openalex.org/W2043103025","https://openalex.org/W2045478914","https://openalex.org/W2071996424","https://openalex.org/W2076953985","https://openalex.org/W2083721607","https://openalex.org/W2092088084","https://openalex.org/W2093521383","https://openalex.org/W2101840353","https://openalex.org/W2103819978","https://openalex.org/W2133558852","https://openalex.org/W2140323637","https://openalex.org/W2141063536","https://openalex.org/W2142497985","https://openalex.org/W2151623627","https://openalex.org/W2154344438","https://openalex.org/W2157852649","https://openalex.org/W2162836448","https://openalex.org/W2167800322","https://openalex.org/W2186464837","https://openalex.org/W2290631554","https://openalex.org/W2396170234","https://openalex.org/W2411150599","https://openalex.org/W2417741758","https://openalex.org/W2432198586"],"related_works":["https://openalex.org/W6926605578","https://openalex.org/W2092640063","https://openalex.org/W2136029925","https://openalex.org/W2120349389","https://openalex.org/W1569425147","https://openalex.org/W2133021527","https://openalex.org/W2462293531","https://openalex.org/W2291896838","https://openalex.org/W2062782853","https://openalex.org/W750643889"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Synovial":[1,77],"inflammation":[2],"in":[3,31,38,106,146,156,175,198,213],"rheumatoid":[4],"arthritis":[5],"(RA)":[6],"leads":[7],"to":[8,22,143,162,179,190],"pannus":[9,32,45,107,159,177,199],"tissue":[10,33,42,108,160],"invasion":[11],"and":[12,46,51,62,75,87,98,118,182,200],"destruction":[13],"of":[14,25,44,71,115,196,204,216],"cartilage/bone":[15],"matrix":[16,28],"by":[17],"proteinases.":[18],"Our":[19],"intention":[20],"was":[21,103,124,132],"analyze":[23],"some":[24],"the":[26,140,214,219],"key":[27],"metalloproteinases":[29],"(MMPs)":[30],"overlying":[34],"evolving":[35],"cartilage":[36,221],"erosions":[37,217],"RA.":[39],"METHODS:":[40],"Frozen":[41],"samples":[43],"synovium":[47,52],"from":[48,53],"advanced":[49,157],"RA":[50,158,164,176,185],"osteoarthritic":[54,166],"patients":[55],"were":[56,91,171],"used":[57],"for":[58,128,135],"immunohistochemical,":[59],"western":[60],"blotting":[61],"quantitative":[63,99],"reverse":[64],"transcriptase":[65],"polymerase":[66],"chain":[67],"reaction":[68],"(RT-PCR)":[69],"analysis":[70],"MMP-1,":[72,116,180],"-3,":[73],"-13":[74,117,181],"-14.":[76,119,183],"fibroblast":[78,121],"cultures,":[79],"stimulated":[80],"with":[81,93,110],"tumour":[82],"necrosis":[83],"factor":[84],"alpha":[85],"(TNF-alpha)":[86],"interleukin-1":[88],"beta":[89],"(IL-1beta),":[90],"analyzed":[92],"enzyme-linked":[94],"immunosorbent":[95],"assays":[96],"(ELISA)":[97],"RT-PCR.":[100],"RESULTS:":[101],"MMP-3":[102,150,168,197,205,208],"highly":[104],"expressed":[105],"compared":[109,161,178],"significantly":[111],"lower":[112],"expression":[113,152,195],"levels":[114,170],"In":[120],"cultures":[122],"IL-1beta":[123],"a":[125,210],"potent":[126,134],"stimulus":[127],"MMP-3,":[129],"whereas":[130],"TNF-alpha":[131],"more":[133],"MMP-1.":[136],"CONCLUSION:":[137],"This":[138],"is":[139,153],"first":[141],"study":[142],"demonstrate":[144],"quantitatively":[145],"real":[147],"time":[148],"that":[149,207],"mRNA":[151,169],"clearly":[154,173],"higher":[155],"parallel":[163],"or":[165],"synovium.":[167],"also":[172],"overexpressed":[174],"Advanced":[184],"has":[186],"previously":[187],"been":[188],"found":[189],"overexpress":[191],"IL-1beta.":[192],"The":[193],"high":[194],"IL-1beta,":[201],"mediated":[202],"stimulation":[203],"suggest":[206],"plays":[209],"significant":[211],"role":[212],"progression":[215],"through":[218],"proteoglycan-rich":[220],"matrix.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}