{"id":"https://openalex.org/W2325770742","doi":"https://doi.org/10.1056/nejm197006182822501","title":"Efficacy of Conventional Pituitary Irradiation in Acromegaly","display_name":"Efficacy of Conventional Pituitary Irradiation in Acromegaly","publication_year":1970,"publication_date":"1970-06-18","ids":{"openalex":"https://openalex.org/W2325770742","doi":"https://doi.org/10.1056/nejm197006182822501","mag":"2325770742","pmid":"https://pubmed.ncbi.nlm.nih.gov/5445526"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197006182822501","doi":"https://doi.org/10.1056/nejm197006182822501","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197006182822501","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112097822","display_name":"Jesse Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jesse Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Gorden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003799298","display_name":"Kirkland C. Brace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kirkland Brace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.4257,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.98425315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"282","issue":"25","first_page":"1385","last_page":"1391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":1.0},{"id":"https://openalex.org/keywords/pituitary-irradiation","display_name":"pituitary irradiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/plasma-growth-hormone-levels","display_name":"plasma growth hormone","score":0.8009999990463257},{"id":"https://openalex.org/keywords/growth-hormone-suppression","display_name":"growth hormone suppression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/supervoltage-radiotherapy","display_name":"supervoltage radiotherapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5789999961853027},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.4410000145435333},{"id":"https://openalex.org/keywords/proton-irradiation","display_name":"proton irradiation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.9554577469825745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8391348123550415},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.7261264324188232},{"id":"https://openalex.org/C2780104272","wikidata":"https://www.wikidata.org/wiki/Q933496","display_name":"Hypophysectomy","level":3,"score":0.6411272883415222},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6194177865982056},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5028778910636902},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.47955605387687683},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4649072587490082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4350739121437073},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38204216957092285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3741980195045471},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3648739457130432},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35851535201072693},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010910","descriptor_name":"Pituitary Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012658","descriptor_name":"Sella Turcica","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012658","descriptor_name":"Sella Turcica","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197006182822501","doi":"https://doi.org/10.1056/nejm197006182822501","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197006182822501","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:5445526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5445526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W174670461","https://openalex.org/W1603688983","https://openalex.org/W1991846063","https://openalex.org/W2003216598","https://openalex.org/W2010985011","https://openalex.org/W2014241772","https://openalex.org/W2054445485","https://openalex.org/W2075751743","https://openalex.org/W2082091715","https://openalex.org/W2085963186","https://openalex.org/W2087867814","https://openalex.org/W2088055122","https://openalex.org/W2095015071","https://openalex.org/W2112397102","https://openalex.org/W2126125587","https://openalex.org/W2129879799","https://openalex.org/W2145682466","https://openalex.org/W2150856982","https://openalex.org/W2158162115","https://openalex.org/W2325449425","https://openalex.org/W2416862989","https://openalex.org/W4252758773"],"related_works":["https://openalex.org/W1979748274","https://openalex.org/W2086985095","https://openalex.org/W7098897484","https://openalex.org/W2126490056","https://openalex.org/W2027540031","https://openalex.org/W2562194873","https://openalex.org/W7100036953","https://openalex.org/W2162792057","https://openalex.org/W2118164366","https://openalex.org/W4236013863"],"abstract_inverted_index":{"External":[0],"irradiation":[1,113,141],"of":[2,20,107,112,153],"the":[3,32,40,68,118,127],"pituitary":[4],"gland":[5],"with":[6,23,138],"4000":[7],"Ft":[8],"from":[9,144],"a":[10,63,89],"conventional":[11,139],"supervoltage":[12],"source":[13],"reduced":[14],"plasma":[15,36,101,123],"growth":[16,124],"hormone":[17,37,102,125],"in":[18,35,100,122,130],"19":[19],"20":[21],"patients":[22,55,134],"acromegaly.":[24],"By":[25],"one":[26,87,92],"to":[27,49,65,76],"two":[28,61],"years":[29],"after":[30],"irradiation,":[31,151],"mean":[33,69],"fall":[34],"concentration":[38],"for":[39,149],"entire":[41],"group":[42],"was":[43,71,114],"51":[44],"per":[45,51,73,78],"cent":[46,74],"(range,":[47],"0":[48],"88":[50],"cent).":[52,79],"In":[53],"seven":[54,81],"who":[56],"were":[57],"studied":[58],"again":[59],"at":[60,117],"and":[62,96,126,157],"half":[64],"four":[66],"years,":[67],"decrease":[70],"76":[72],"(60":[75],"89":[77],"Of":[80],"untreated":[82],"but":[83],"otherwise":[84],"comparable":[85],"patients,":[86],"had":[88,93,98],"slight":[90],"reduction,":[91],"no":[94],"change,":[95],"five":[97],"rises":[99],"concentrations":[103],"over":[104],"similar":[105],"periods":[106],"observation.":[108],"The":[109,120],"only":[110],"complication":[111],"hair":[115],"loss":[116],"temples.":[119],"falls":[121],"wide":[128],"variation":[129],"benefit":[131],"among":[132],"individual":[133],"that":[135],"we":[136],"observed":[137],"external":[140],"are":[142],"indistinguishable":[143],"results":[145],"reported":[146],"by":[147],"others":[148],"proton-beam":[150],"implants":[152],"radioactive":[154],"yttrium,":[155],"cryohypophysectomy":[156],"surgical":[158],"hypophysectomy.":[159]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}