{"id":"https://openalex.org/W2325757775","doi":"https://doi.org/10.1227/01.neu.0000435119.56571.18","title":"Dopamine as the Fountain of Youth?","display_name":"Dopamine as the Fountain of Youth?","publication_year":2013,"publication_date":"2013-09-20","ids":{"openalex":"https://openalex.org/W2325757775","doi":"https://doi.org/10.1227/01.neu.0000435119.56571.18","mag":"2325757775","pmid":"https://pubmed.ncbi.nlm.nih.gov/24051717"},"language":"en","primary_location":{"id":"doi:10.1227/01.neu.0000435119.56571.18","doi":"https://doi.org/10.1227/01.neu.0000435119.56571.18","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000435119.56571.18","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055913904","display_name":"S Badugu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Badugu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043335263","display_name":"William Stanley Anderson","orcid":"https://orcid.org/0000-0003-0958-050X","observed_orcids":["https://orcid.org/0000-0003-0958-050X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"WS Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1634,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55624541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"73","issue":"4","first_page":"N19","last_page":"N20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reward-prediction-error","display_name":"reward prediction error","score":0.8790000081062317},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8240000009536743},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9449999928474426},{"id":"https://openalex.org/keywords/two-armed-bandit-task","display_name":"two-armed bandit task","score":0.8510000109672546},{"id":"https://openalex.org/keywords/substantia-nigra-ventral-tegmental-area","display_name":"substantia nigra/ventral tegmental area","score":0.875},{"id":"https://openalex.org/keywords/ventral-striatum","display_name":"ventral striatum","score":0.9679999947547913},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.5550000071525574},{"id":"https://openalex.org/keywords/expected-value","display_name":"expected value","score":0.38100001215934753},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cognitive-decline-in-older-adults","display_name":"cognitive decline in older adults","score":0.5839999914169312},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.5120000243186951},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.7120540738105774},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6511252522468567},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6374688148498535},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6366994976997375},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.568877100944519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5550861954689026},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4886224865913391},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4376237690448761},{"id":"https://openalex.org/C130619582","wikidata":"https://www.wikidata.org/wiki/Q7619797","display_name":"Stop signal","level":3,"score":0.417081356048584},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3610435128211975},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.33594971895217896},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3082181215286255},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08818128705024719},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1227/01.neu.0000435119.56571.18","doi":"https://doi.org/10.1227/01.neu.0000435119.56571.18","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000435119.56571.18","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:24051717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24051717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"News"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2129300218","https://openalex.org/W2767438557","https://openalex.org/W2972560979","https://openalex.org/W134222348","https://openalex.org/W1995200787","https://openalex.org/W3125509623","https://openalex.org/W2310633008","https://openalex.org/W2008855267","https://openalex.org/W2001885697","https://openalex.org/W7011598010"],"abstract_inverted_index":{"Review":[0],"of:":[1],"Chowdhury":[2,71,603],"R,":[3,761],"Guitart-Masip":[4,762],"M,":[5,763],"Lambert":[6,764],"C,":[7,765],"Dayan":[8],"P,":[9],"Huys":[10],"Q,":[11],"D\u00fczel":[12],"E,":[13],"Dolan":[14],"RJ.":[15],"Dopamine":[16,668,768],"restores":[17,769],"reward":[18,148,349,465,478,618,719,770],"prediction":[19,149,466,771],"errors":[20,467,772],"in":[21,29,54,66,78,84,96,100,127,163,166,171,251,343,392,431,479,489,516,530,534,613,631,644,647,679,707,723,739,773],"old":[22,774],"age.":[23,775],"Nat":[24,776],"Neurosci":[25],"2013;16:648-653.":[26],"Clinicians":[27],"working":[28],"the":[30,38,44,79,97,101,116,137,140,167,172,180,219,256,265,285,321,327,334,344,347,353,358,379,397,416,432,450,461,480,490,510,535,555,563,570,593,614,621,639,671,675,680,686,691,703,713,724,728,731,736,740,745],"movement":[31],"disorders":[32],"field":[33],"are":[34],"quite":[35],"familiar":[36],"with":[37,132,179,262,400,434,449,469,518,569,617],"effects":[39],"of":[40,46,81,93,103,115,130,136,139,182,198,223,228,258,264,299,340,346,452,460,550,588,623,641,649,674,688,712,747],"dopaminergic":[41,552,642],"agents":[42],"on":[43,214,269,288,320,539,698],"symptoms":[45],"Parkinson's":[47],"disease.":[48],"Basal":[49],"ganglia":[50],"circuitry":[51,590,646],"is":[52,144,161,685],"involved":[53],"many":[55],"cognitive":[56],"functions":[57],"as":[58,337,413,447,579],"well,":[59],"and":[60,106,157,191,218,255,333,391,504,557,657,720],"L-DOPA":[61,104,300,409,421,445,494,519,582,699,729],"conceivably":[62],"could":[63,124,658],"be":[64,125],"useful":[65],"conditions":[67],"degrading":[68],"these":[69],"functions.":[70],"et":[72,185,604,766],"al":[73,186,605],"have":[74],"now":[75],"explored":[76],"this":[77,158,207,531,589],"context":[80,102],"decision":[82,94,628],"making":[83,95,629],"an":[85],"older":[86,109,164,189,281,369,380,387,398,491,572,594,632],"population.":[87],"These":[88],"authors":[89,542],"studied":[90,187],"fMRI":[91,113,458],"signatures":[92,114],"nucleus":[98,141,462,536],"accumbens":[99,142,463,537],"administration,":[105,503],"found":[107,606],"that":[108,513,596,607],"people":[110],"had":[111],"abnormal":[112,162],"expected":[117,348,477,528,676,721,732],"value":[118,350,677,722,733],"during":[119,501],"a":[120,128,147,196,202,215,229,234,237,259,270,275,303,338,393,453,474,548],"choice":[121,168,199,356,483,682,725],"task,":[122,357,683],"which":[123],"corrected":[126,178,377],"subset":[129],"subjects":[131,492],"L-DOPA.":[133,183,384,540,600],"Specifically,":[134],"part":[135],"function":[138,339],"(NA)":[143],"to":[145,153,274,323,363,415,546,592,654,744],"provide":[146],"error":[150,611],"(RPE)":[151],"signal":[152,160,175,734,742],"other":[154],"brain":[155,615,650],"structures,":[156],"RPE":[159,470],"adults":[165,190,194,360,370,381,388,399,433],"task":[169,200,286,428,484],"used":[170,250,544],"study.":[173],"This":[174,374,496],"was":[176,317,376,427,487,498,505],"subsequently":[177],"administration":[181,446,520,609,669],"Chowdury":[184],"32":[188],"22":[192],"younger":[193,306],"performing":[195,418],"type":[197],"having":[201],"two-armed":[203,354,481],"bandit":[204,355,482,681],"design.":[205],"In":[206,352,601],"test,":[208],"two":[209,246,266,292],"fractal":[210,247],"images":[211,248,267],"were":[212,249,361,382],"displayed":[213],"computer":[216],"screen,":[217],"participant":[220],"chose":[221],"one":[222,263],"them.":[224],"The":[225,244,280,305,541,634,695],"subsequent":[226],"display":[227],"green":[230],"up":[231],"arrow":[232],"indicated":[233,241],"\u201cwin,\u201d":[235],"while":[236,538],"yellow":[238],"horizontal":[239],"bar":[240],"no":[242],"win.":[243],"same":[245],"each":[252],"trial":[253],"iteration,":[254],"probability":[257],"win":[260],"associated":[261,616],"varied":[268],"trial-by-trial":[271],"basis":[272],"according":[273],"Gaussian":[276],"random":[277],"walk":[278],"distribution.":[279],"subject":[282],"group":[283,308,532,574,576,595,700],"performed":[284,319,405,488],"twice":[287],"separate":[289],"days":[290],"under":[291],"conditions,":[293],"either":[294],"after":[295,302,407,420,444,493],"taking":[296],"150":[297],"mg":[298],"or":[301],"placebo.":[304,373],"age":[307,626],"did":[309],"not":[310,499,577,652],"undergo":[311],"pharmacologic":[312],"manipulation.":[313],"Diffusion-tensor":[314],"MRI":[315],"imaging":[316,486],"also":[318,442,543],"participants":[322],"investigate":[324],"connectivity":[325,553,566],"between":[326,554],"substantia":[328],"nigra/ventral":[329],"tegmental":[330],"area":[331],"(SN/VTA)":[332],"ventral":[335,560],"striatum":[336,558],"inter-individual":[341],"differences":[342],"expression":[345],"signal.":[351],"young":[359],"able":[362],"earn":[364],"significantly":[365,598],"more":[366,475,515,526],"money":[367],"than":[368],"who":[371],"received":[372],"difference":[375],"when":[378,485,507],"administered":[383],"Not":[385,425],"all":[386],"improved":[389,430,443],"however,":[390],"median":[394,511],"split":[395],"analysis,":[396],"higher":[401,585],"baseline":[402,436],"performance":[403,429],"actually":[404],"worse":[406],"receiving":[408],"(the":[410,422,521,575],"\u201cwin-less\u201d":[411,571],"group)":[412],"compared":[414,591],"subgroup":[417,512],"better":[419],"\u201cwin-more\u201d":[423,522],"group).":[424],"only":[426],"lower":[435],"performance,":[437],"but":[438],"their":[439],"learning":[440,456],"rate":[441],"demonstrated":[448,464],"application":[451],"parametrized":[454],"reinforcement":[455],"model.":[457],"analysis":[459],"consistent":[468],"signals":[471,612],"biased":[472],"by":[473,752],"negative":[476,527,672,705,737],"administration.":[495],"effect":[497,673],"seen":[500],"placebo":[502],"accentuated":[506],"studying":[508],"specifically":[509,701],"benefited":[514,597],"general":[517],"group),":[523],"implying":[524,584,620],"even":[525],"values":[529],"represented":[533],"DTI":[545],"derive":[547],"measure":[549],"predominantly":[551],"SN/VTA":[556],"(whose":[559],"portion":[561],"incudes":[562],"NA).":[564],"Greater":[565],"strength":[567],"correlated":[568],"adult":[573],"benefiting":[578],"much":[580],"from":[581,599,754],"administration),":[583],"base-line":[586],"integrity":[587],"summary,":[602],"dopamine":[608],"restored":[610],"prediction,":[619],"possibility":[622],"clinically":[624],"improving":[625],"related":[627,653],"problems":[630],"adults.":[633],"study":[635],"further":[636,659],"points":[637],"out":[638],"importance":[640],"modulation":[643],"subcortical":[645],"aspects":[648],"functioning":[651],"motor":[655],"control,":[656],"research":[660],"efforts":[661],"at":[662],"new":[663],"neuromodulatory":[664],"targets.Figure":[665],"1:":[666],"(A)":[667],"corrects":[670],"(Q)":[678],"circled":[684],"region":[687],"interest":[689],"for":[690,717],"right":[692],"NA.":[693],"(B)":[694],"\u201cwin":[696],"more\u201d":[697],"showed":[702],"largest":[704],"shift":[706,738],"Q.":[708],"(C)":[709],"Time":[710],"course":[711],"NA":[714],"BOLD":[715,741],"response":[716],"both":[718],"task.":[726],"Under":[727],"condition,":[730],"demonstrates":[735],"corresponding":[743],"time":[746],"outcome":[748],"(gray":[749],"box).":[750],"Reprinted":[751],"permission":[753],"Macmillan":[755],"Publishers":[756],"Ltd:":[757],"Scientific":[758],"Reports":[759],"(Chowdhury":[760],"al.":[767],"Neurosci.":[777],"2013;16(5):":[778],"648-53.":[779],"doi:":[780],"10.1038/nn.3364.":[781],"Epub":[782],"2013":[783],"Mar":[784],"24.":[785]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}