{"id":"https://openalex.org/W2325544016","doi":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","title":"OP0181 Treating to Target of Minimal Disease Activity and Normal Function in Polyarticular Juvenile Idiopathic Arthritis with Adalimumab: Analysis from A Phase 3 Clinical Trial","display_name":"OP0181 Treating to Target of Minimal Disease Activity and Normal Function in Polyarticular Juvenile Idiopathic Arthritis with Adalimumab: Analysis from A Phase 3 Clinical Trial","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W2325544016","doi":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","mag":"2325544016"},"language":"en","primary_location":{"id":"doi:10.1136/annrheumdis-2014-eular.1600","doi":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080140512","display_name":"Nicolino Ruperto","orcid":"https://orcid.org/0000-0001-8407-7782","observed_orcids":["https://orcid.org/0000-0001-8407-7782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Ruperto","raw_affiliation_strings":["Printo-IRCCS, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Printo-IRCCS, Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068517463","display_name":"Daniel J. Lovell","orcid":"https://orcid.org/0000-0003-1604-0130","observed_orcids":["https://orcid.org/0000-0003-1604-0130"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Lovell","raw_affiliation_strings":["PRCSG, Cincinnati Children's Hospital Medical Center, Cincinnati, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRCSG, Cincinnati Children's Hospital Medical Center, Cincinnati, United States","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079738832","display_name":"Pierre Quartier","orcid":"https://orcid.org/0000-0002-1769-549X","observed_orcids":["https://orcid.org/0000-0002-1769-549X"]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Quartier","raw_affiliation_strings":["H\u00f4pital Necker-Enfants Malades, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Necker-Enfants Malades, Paris, France","institution_ids":["https://openalex.org/I1288880153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029874460","display_name":"Angelo Ravelli","orcid":"https://orcid.org/0000-0001-9658-0385","observed_orcids":["https://orcid.org/0000-0001-9658-0385"]},"institutions":[{"id":"https://openalex.org/I2801463291","display_name":"Istituto Giannina Gaslini","ror":"https://ror.org/0424g0k78","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2801463291","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Ravelli","raw_affiliation_strings":["Istituto G. Gaslini and Universit\u00e0 degli Studi di Genovav, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto G. Gaslini and Universit\u00e0 degli Studi di Genovav, Genova, Italy","institution_ids":["https://openalex.org/I2801463291","https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086383814","display_name":"Mahinda Karunaratne","orcid":"https://orcid.org/0009-0005-5754-5110","observed_orcids":["https://orcid.org/0009-0005-5754-5110"]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Karunaratne","raw_affiliation_strings":["AbbVie, North Chicago, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, North Chicago, United States","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051410507","display_name":"Jasmina Kalabic","orcid":"https://orcid.org/0009-0007-4698-1042","observed_orcids":["https://orcid.org/0009-0007-4698-1042"]},"institutions":[{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Kalabic","raw_affiliation_strings":["AbbVie Deutschland GmbH and Co. KG, Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Deutschland GmbH and Co. KG, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210128201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013403456","display_name":"Anita dos Santos Cardoso","orcid":"https://orcid.org/0000-0002-2846-9682","observed_orcids":["https://orcid.org/0000-0002-2846-9682"]},"institutions":[{"id":"https://openalex.org/I4405255806","display_name":"AbbVie (Portugal)","ror":"https://ror.org/03em9qx04","country_code":"PT","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4405255806"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"A. Cardoso","raw_affiliation_strings":["AbbVie, Amadora, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Amadora, Portugal","institution_ids":["https://openalex.org/I4405255806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612338","display_name":"Alberto Martini","orcid":"https://orcid.org/0000-0001-7642-1459","observed_orcids":["https://orcid.org/0000-0001-7642-1459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Martini","raw_affiliation_strings":["Printo-IRCCS, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Printo-IRCCS, Genova, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053719643","display_name":"Gerd Horneff","orcid":"https://orcid.org/0000-0001-5491-7832","observed_orcids":["https://orcid.org/0000-0001-5491-7832"]},"institutions":[{"id":"https://openalex.org/I4210128171","display_name":"Asklepios Klinik Sankt Augustin","ror":"https://ror.org/038v5jv72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210128171"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Horneff","raw_affiliation_strings":["Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany","institution_ids":["https://openalex.org/I4210128171"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4870,"currency":"USD","value_usd":4870},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":null,"first_page":"130","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyarticular-juvenile-idiopathic-arthritis","display_name":"polyarticular juvenile idiopathic arthritis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treat-to-target","display_name":"treat-to-target","score":0.7590000033378601},{"id":"https://openalex.org/keywords/minimal-disease-activity","display_name":"minimal disease activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.7260000109672546},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.4169999957084656},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.6539999842643738},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/pediatric-rheumatology","display_name":"pediatric rheumatology","score":0.6700000166893005},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.6420000195503235},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9166901111602783},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.8691151738166809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6281205415725708},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.622948408126831},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5852923393249512},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5264424085617065},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.45054730772972107},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4499453604221344},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41385582089424133},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.4137935936450958},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4097691774368286},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1023230254650116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/annrheumdis-2014-eular.1600","doi":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","is_oa":false,"landing_page_url":"https://doi.org/10.1136/annrheumdis-2014-eular.1600","pdf_url":null,"source":{"id":"https://openalex.org/S25650217","display_name":"Annals of the Rheumatic Diseases","issn_l":"0003-4967","issn":["0003-4967","1468-2060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the Rheumatic Diseases","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416152099","https://openalex.org/W2100120281","https://openalex.org/W7095824066","https://openalex.org/W4232543358","https://openalex.org/W2315815725","https://openalex.org/W2552108668","https://openalex.org/W2967504655","https://openalex.org/W2111699922","https://openalex.org/W2214645748","https://openalex.org/W3043661113"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2016-06-24T00:00:00"}