{"id":"https://openalex.org/W2325399416","doi":"https://doi.org/10.1021/cb400906e","title":"Cruentaren A Binds F1F0 ATP Synthase To Modulate the Hsp90 Protein Folding Machinery","display_name":"Cruentaren A Binds F1F0 ATP Synthase To Modulate the Hsp90 Protein Folding Machinery","publication_year":2014,"publication_date":"2014-01-22","ids":{"openalex":"https://openalex.org/W2325399416","doi":"https://doi.org/10.1021/cb400906e","mag":"2325399416","pmid":"https://pubmed.ncbi.nlm.nih.gov/24450340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090037"},"language":"en","primary_location":{"id":"doi:10.1021/cb400906e","doi":"https://doi.org/10.1021/cb400906e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cb400906e","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/cb400906e","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jessica A. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica A. Hall","raw_affiliation_strings":["The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029732899","display_name":"Bhaskar Reddy Kusuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhaskar Reddy Kusuma","raw_affiliation_strings":["The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082865616","display_name":"Gary E. L. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary E. L. Brandt","raw_affiliation_strings":["The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062921807","display_name":"Brian S. J. Blagg","orcid":"https://orcid.org/0000-0002-6200-3480","observed_orcids":["https://orcid.org/0000-0002-6200-3480"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian S. J. Blagg","raw_affiliation_strings":["The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Kansas , , 1251 Wescoe Hall Drive, Malott 4070 , , ,","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7562, United States","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062921807"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.0929,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.76487392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"976","last_page":"985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/f0f1-atp-synthase","display_name":"F0F1-ATP synthase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hsp90-inhibition","display_name":"HSP90 inhibition","score":0.7239999771118164},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.6690000295639038},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.5509999990463257},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.3700000047683716},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.9480509161949158},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.7209987044334412},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6504473090171814},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6000688672065735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5765105485916138},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5756381154060364},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5679157972335815},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5324519872665405},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.45383620262145996},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.43559741973876953},{"id":"https://openalex.org/C141109615","wikidata":"https://www.wikidata.org/wiki/Q5137430","display_name":"Co-chaperone","level":5,"score":0.4340227246284485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42271989583969116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4019087851047516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3936674892902374},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24067699909210205},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0693562924861908},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018942","descriptor_name":"Macrolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025261","descriptor_name":"Mitochondrial Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/cb400906e","doi":"https://doi.org/10.1021/cb400906e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cb400906e","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4090037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4090037","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chem Biol","raw_type":"Text"},{"id":"pmid:24450340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24450340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.812.8240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.812.8240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b9/bc/cb400906e.PMC4090037.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1021/cb400906e","doi":"https://doi.org/10.1021/cb400906e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cb400906e","pdf_url":null,"source":{"id":"https://openalex.org/S118914585","display_name":"ACS Chemical Biology","issn_l":"1554-8929","issn":["1554-8929","1554-8937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7050361831","display_name":null,"funder_award_id":"CA109265","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7583821793","display_name":"HSP90 Inhibitors","funder_award_id":"U01CA109265","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W153442697","https://openalex.org/W183275956","https://openalex.org/W1576929531","https://openalex.org/W1758280303","https://openalex.org/W1975725292","https://openalex.org/W1981883819","https://openalex.org/W1993549724","https://openalex.org/W1996436581","https://openalex.org/W2000929246","https://openalex.org/W2004893394","https://openalex.org/W2013888645","https://openalex.org/W2015110311","https://openalex.org/W2016663716","https://openalex.org/W2019676836","https://openalex.org/W2020742237","https://openalex.org/W2021593763","https://openalex.org/W2022209987","https://openalex.org/W2022531767","https://openalex.org/W2026771902","https://openalex.org/W2026972184","https://openalex.org/W2032255930","https://openalex.org/W2034773856","https://openalex.org/W2052055418","https://openalex.org/W2052697091","https://openalex.org/W2056870618","https://openalex.org/W2072088409","https://openalex.org/W2081546418","https://openalex.org/W2087427383","https://openalex.org/W2094861086","https://openalex.org/W2112338871","https://openalex.org/W2115527176","https://openalex.org/W2116393881","https://openalex.org/W2117479168","https://openalex.org/W2129316504","https://openalex.org/W2134175129","https://openalex.org/W2139820020","https://openalex.org/W2152415425","https://openalex.org/W2157273788","https://openalex.org/W2269538007"],"related_works":["https://openalex.org/W1975725292","https://openalex.org/W4288068323","https://openalex.org/W2147314020","https://openalex.org/W2315688363","https://openalex.org/W3106906442","https://openalex.org/W2439979294","https://openalex.org/W2982597658","https://openalex.org/W2116479282","https://openalex.org/W1983388930","https://openalex.org/W2753639783"],"abstract_inverted_index":{"The":[0],"molecular":[1],"chaperone":[2],"Hsp90":[3,20,37,51,90],"requires":[4],"the":[5,14,29,50,58,76,89,95,120,134],"assistance":[6],"of":[7,17,31,70,94,101,109,133],"immunophilins,":[8],"co-chaperones,":[9],"and":[10,125],"partner":[11],"proteins":[12],"for":[13],"conformational":[15],"maturation":[16],"client":[18,128],"proteins.":[19],"inhibition":[21,100,108],"represents":[22],"a":[23],"promising":[24],"anticancer":[25],"strategy":[26],"due":[27],"to":[28,45,99,118],"dependence":[30],"numerous":[32],"oncogenic":[33],"signaling":[34],"pathways":[35],"upon":[36],"function.":[38],"Historically,":[39],"small":[40],"molecules":[41,55,82],"have":[42],"been":[43],"designed":[44],"inhibit":[46],"ATPase":[47],"activity":[48],"at":[49],"N-terminus;":[52],"however,":[53],"these":[54],"also":[56],"induce":[57],"pro-survival":[59],"heat":[60],"shock":[61],"response":[62],"(HSR).":[63],"Therefore,":[64],"inhibitors":[65],"that":[66,72,83],"exhibit":[67],"alternative":[68],"mechanisms":[69],"action":[71],"do":[73],"not":[74],"elicit":[75],"HSR":[77],"are":[78],"actively":[79],"sought.":[80],"Small":[81],"disrupt":[84,119],"Hsp90-co-chaperone":[85],"interactions":[86],"can":[87],"destabilize":[88],"complex":[91],"without":[92,131],"induction":[93,132],"HSR,":[96],"which":[97],"leads":[98],"cell":[102],"proliferation.":[103],"In":[104],"this":[105],"article,":[106],"selective":[107],"F1F0":[110],"ATP":[111,122],"synthase":[112,123],"by":[113],"cruentaren":[114],"A":[115],"was":[116],"shown":[117],"Hsp90-F1F0":[121],"interaction":[124],"result":[126],"in":[127],"protein":[129],"degradation":[130],"HSR.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}