{"id":"https://openalex.org/W2325317401","doi":"https://doi.org/10.1097/fjc.0000000000000145","title":"Erythropoietin Prevents Endothelial Dysfunction in GTP-cyclohydrolase I\u2013deficient hph1 Mice","display_name":"Erythropoietin Prevents Endothelial Dysfunction in GTP-cyclohydrolase I\u2013deficient hph1 Mice","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2325317401","doi":"https://doi.org/10.1097/fjc.0000000000000145","mag":"2325317401","pmid":"https://pubmed.ncbi.nlm.nih.gov/25490417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4261745"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0000000000000145","doi":"https://doi.org/10.1097/fjc.0000000000000145","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000145","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4261745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031586964","display_name":"Livius V. d\u2019Uscio","orcid":"https://orcid.org/0000-0001-9577-9480","observed_orcids":["https://orcid.org/0000-0001-9577-9480"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livius V. d\u02bcUscio","raw_affiliation_strings":["Departments of *Anesthesiology; and \u2020Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","Anesthesiology","Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology; and \u2020Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113668053","display_name":"Anantha Vijay R. Santhanam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anantha V. R. Santhanam","raw_affiliation_strings":["Anesthesiology; and","Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology; and","institution_ids":[]},{"raw_affiliation_string":"Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Anesthesiology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082346434","display_name":"Zvonimir S. Katu\u0161i\u0107","orcid":"https://orcid.org/0000-0001-7016-7883","observed_orcids":["https://orcid.org/0000-0001-7016-7883"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zvonimir S. Katusic","raw_affiliation_strings":["Anesthesiology; and","Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology; and","institution_ids":[]},{"raw_affiliation_string":"Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Anesthesiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082346434","https://openalex.org/A5113668053"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.8864,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76189672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"64","issue":"6","first_page":"514","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.921999990940094},{"id":"https://openalex.org/keywords/tetrahydrobiopterin-deficiency","display_name":"tetrahydrobiopterin deficiency","score":0.906000018119812},{"id":"https://openalex.org/keywords/7-8-dihydrobiopterin","display_name":"7,8-dihydrobiopterin","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase-uncoupling","display_name":"endothelial nitric oxide synthase uncoupling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5419999957084656},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7929999828338623},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.9067529439926147},{"id":"https://openalex.org/C2775956414","wikidata":"https://www.wikidata.org/wiki/Q1487359","display_name":"GTP cyclohydrolase I","level":5,"score":0.7871106266975403},{"id":"https://openalex.org/C2777451243","wikidata":"https://www.wikidata.org/wiki/Q408256","display_name":"Biopterin","level":5,"score":0.7676425576210022},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7373993992805481},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7324903607368469},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7180832624435425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6880616545677185},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6494980454444885},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5993479490280151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5367860198020935},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5243121385574341},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4776131808757782},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.4503832459449768},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.44332244992256165},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.43651601672172546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32797616720199585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27758312225341797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20509681105613708},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12016698718070984}],"mesh":[{"descriptor_ui":"D000068817","descriptor_name":"Epoetin Alfa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/fjc.0000000000000145","doi":"https://doi.org/10.1097/fjc.0000000000000145","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000145","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:25490417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25490417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4261745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4261745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cardiovasc Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4261745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4261745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cardiovasc Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1716000982","display_name":"Mechanisms of endothelial repair after vascular injury","funder_award_id":"R01HL091867","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3140932608","display_name":null,"funder_award_id":"HL91867","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5052002404","display_name":null,"funder_award_id":"HL-111062","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7166223617","display_name":"Endothelial Dysfunction In The Cerebral Circulation","funder_award_id":"R01HL111062","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1504583940","https://openalex.org/W1607113137","https://openalex.org/W1899050407","https://openalex.org/W1919315131","https://openalex.org/W1946153048","https://openalex.org/W1965339862","https://openalex.org/W1968053139","https://openalex.org/W1972861299","https://openalex.org/W1975319023","https://openalex.org/W1979069114","https://openalex.org/W1980632497","https://openalex.org/W1988035690","https://openalex.org/W1988559818","https://openalex.org/W1994135664","https://openalex.org/W1994428345","https://openalex.org/W1998581885","https://openalex.org/W2002945974","https://openalex.org/W2004398529","https://openalex.org/W2005495277","https://openalex.org/W2024848503","https://openalex.org/W2026425756","https://openalex.org/W2029738096","https://openalex.org/W2030597605","https://openalex.org/W2042038416","https://openalex.org/W2048574237","https://openalex.org/W2051066066","https://openalex.org/W2055870525","https://openalex.org/W2057683250","https://openalex.org/W2058141781","https://openalex.org/W2059067398","https://openalex.org/W2064956702","https://openalex.org/W2069153850","https://openalex.org/W2070542275","https://openalex.org/W2071186420","https://openalex.org/W2082665949","https://openalex.org/W2086824174","https://openalex.org/W2091013562","https://openalex.org/W2092529244","https://openalex.org/W2096015332","https://openalex.org/W2100072314","https://openalex.org/W2106121696","https://openalex.org/W2106894101","https://openalex.org/W2117483991","https://openalex.org/W2120612885","https://openalex.org/W2127072099","https://openalex.org/W2132380263","https://openalex.org/W2145561716","https://openalex.org/W2146753487","https://openalex.org/W2147604739","https://openalex.org/W2148657070","https://openalex.org/W2152172533","https://openalex.org/W2153935901","https://openalex.org/W2158139135","https://openalex.org/W2158202760","https://openalex.org/W2162211931","https://openalex.org/W2166941736","https://openalex.org/W2167380757","https://openalex.org/W2171768996"],"related_works":["https://openalex.org/W2047096703","https://openalex.org/W2096015332","https://openalex.org/W2266935847","https://openalex.org/W7095646939","https://openalex.org/W2282307251","https://openalex.org/W1994428345","https://openalex.org/W2158202760","https://openalex.org/W2266010738","https://openalex.org/W7100960342","https://openalex.org/W2153935901"],"abstract_inverted_index":{":":[0],"In":[1,132],"this":[2],"study,":[3],"we":[4],"used":[5],"the":[6,22,75,147],"mutant":[7],"hph1":[8,53,88,130,150],"mouse":[9],"model,":[10],"which":[11],"has":[12],"deficiency":[13,64],"in":[14,52,74,79,113,127,146],"GTP-cyclohydrolase":[15],"I":[16,44],"(GTPCH":[17],"I)":[18],"activity,":[19],"to":[20,84,110,175],"test":[21],"hypothesis":[23],"that":[24,155],"erythropoietin":[25],"(EPO)":[26],"protects":[27],"aortic":[28],"wall":[29],"from":[30],"oxidative":[31,160],"stress":[32,161],"induced":[33],"by":[34,105,166,184],"uncoupling":[35],"of":[36,68,81,87,120,129,139,149,172],"endothelial":[37,163],"nitric":[38],"oxide":[39],"synthase":[40],"(eNOS).":[41],"Both":[42],"GTPCH":[43],"activity":[45],"and":[46,71,107,123,144,162],"tetrahydrobiopterin":[47],"(BH4)":[48],"levels":[49,58],"were":[50,59],"reduced":[51],"mice,":[54],"whereas":[55],"7,8-dihydrobiopterin":[56],"(7,8-BH2)":[57],"significantly":[60,100,117],"increased.":[61],"Furthermore,":[62],"BH4":[63,109,188],"caused":[65,165],"increased":[66,136],"production":[67,104,119],"superoxide":[69,102],"anion":[70,103],"hydrogen":[72,121],"peroxide":[73,122],"aorta":[76,148],"thus":[77],"resulting":[78],"impairment":[80],"endothelium-dependent":[82,125],"relaxations":[83,126],"acetylcholine.":[85],"Treatment":[86],"mice":[89],"with":[90,157],"recombinant":[91],"human":[92],"EPO":[93,115,134,158,185],"(1000":[94],"U/kg,":[95],"subcutaneously":[96],"for":[97],"3":[98],"days)":[99],"decreased":[101,118],"eNOS":[106,167],"improved":[108,124],"7,8-BH2":[111],"ratio":[112],"aortas.":[114],"also":[116],"aortas":[128],"mice.":[131,151],"addition,":[133],"treatment":[135,156],"protein":[137],"expressions":[138,171],"copper-/zinc-superoxide":[140],"dismutase,":[141,143],"manganese-superoxide":[142],"catalase":[145],"Our":[152],"findings":[153],"demonstrate":[154],"prevented":[159],"dysfunction":[164],"uncoupling.":[168],"Increased":[169],"vascular":[170,182],"antioxidants":[173],"seem":[174],"be":[176],"an":[177],"important":[178],"molecular":[179],"mechanism":[180],"underlying":[181],"protection":[183],"during":[186],"chronic":[187],"deficiency.":[189]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}