{"id":"https://openalex.org/W2324880947","doi":null,"title":"Virtual histology and remodelling index allow in vivo identification of allegedly high-risk coronary plaques in patients with acute coronary syndromes: a three vessel intravascular ultrasound radiofrequency data analysis.","display_name":"Virtual histology and remodelling index allow in vivo identification of allegedly high-risk coronary plaques in patients with acute coronary syndromes: a three vessel intravascular ultrasound radiofrequency data analysis.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W2324880947","mag":"2324880947","pmid":"https://pubmed.ncbi.nlm.nih.gov/19755310"},"language":"en","primary_location":{"id":"pmid:19755310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19755310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081547954","display_name":"H\u00e9ctor M. Garc\u00eda\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0001-5100-0471","observed_orcids":["https://orcid.org/0000-0001-5100-0471"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H\u00e9ctor M Garc\u00eda-Garc\u00eda","raw_affiliation_strings":["Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014155914","display_name":"Dick M. Goedhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dick Goedhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244190","display_name":"Johan C.H. Schuurbiers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan C H Schuurbiers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108286185","display_name":"Neville Kukreja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neville Kukreja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111691012","display_name":"Shuzou Tanimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuzou Tanimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011940077","display_name":"Joost Daemen","orcid":"https://orcid.org/0000-0001-8628-1410","observed_orcids":["https://orcid.org/0000-0001-8628-1410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joost Daemen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111960921","display_name":"Marie-Ang\u00e8le M. Morel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Angele M Morel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048087077","display_name":"Marco Bressers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Bressers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110219752","display_name":"Gerrit\u2010Anne van Es","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerrit-Ann van Es","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045033034","display_name":"Jolanda J. Wentzel","orcid":"https://orcid.org/0000-0001-9893-3404","observed_orcids":["https://orcid.org/0000-0001-9893-3404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanda J Wentzel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035843182","display_name":"Frank J H Gijsen","orcid":"https://orcid.org/0000-0001-5246-9060","observed_orcids":["https://orcid.org/0000-0001-5246-9060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Gijsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110953857","display_name":"Anton F. W. van der Steen","orcid":"https://orcid.org/0000-0002-8045-7363","observed_orcids":["https://orcid.org/0000-0002-8045-7363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonius F W van der Steen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063792624","display_name":"Patrick W.J.C. Serruys","orcid":"https://orcid.org/0000-0002-9636-1104","observed_orcids":["https://orcid.org/0000-0002-9636-1104","https://orcid.org/0000-0001-7321-1261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick W Serruys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0382,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88229982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2","issue":"3","first_page":"338","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-histology-intravascular-ultrasound","display_name":"virtual histology intravascular ultrasound","score":0.9089999794960022},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8209999799728394},{"id":"https://openalex.org/keywords/coronary-artery-plaque","display_name":"coronary plaque","score":0.8289999961853027},{"id":"https://openalex.org/keywords/thin-cap-fibroatheroma","display_name":"thin-cap fibroatheroma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/necrotic-core","display_name":"necrotic core","score":0.8519999980926514},{"id":"https://openalex.org/keywords/plaque-composition","display_name":"plaque composition","score":0.781000018119812},{"id":"https://openalex.org/keywords/plaque-burden","display_name":"plaque burden","score":0.7289999723434448},{"id":"https://openalex.org/keywords/calcified-plaque","display_name":"calcified plaque","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8710952997207642},{"id":"https://openalex.org/C2776931568","wikidata":"https://www.wikidata.org/wiki/Q1671577","display_name":"Intravascular ultrasound","level":2,"score":0.8416721820831299},{"id":"https://openalex.org/C2779318932","wikidata":"https://www.wikidata.org/wiki/Q1058276","display_name":"Atheroma","level":2,"score":0.8060176372528076},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.5839655995368958},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.5401557683944702},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.49945855140686035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4836491346359253},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.47671669721603394},{"id":"https://openalex.org/C2778710248","wikidata":"https://www.wikidata.org/wiki/Q17154669","display_name":"Vulnerable plaque","level":2,"score":0.44756805896759033},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4191911816596985},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4027767777442932},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3828546106815338},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.24725255370140076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:19755310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19755310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology","raw_type":"Journal Article"},{"id":"mag:2324880947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19755310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W131800491","https://openalex.org/W201422399","https://openalex.org/W1978684519","https://openalex.org/W1979939384","https://openalex.org/W1982982654","https://openalex.org/W1983102292","https://openalex.org/W1985120247","https://openalex.org/W2001044397","https://openalex.org/W2026856116","https://openalex.org/W2041206609","https://openalex.org/W2047334981","https://openalex.org/W2053504226","https://openalex.org/W2070625439","https://openalex.org/W2081246706","https://openalex.org/W2081546947","https://openalex.org/W2094286022","https://openalex.org/W2101954444","https://openalex.org/W2106289087","https://openalex.org/W2109286340","https://openalex.org/W2112334970","https://openalex.org/W2122201881","https://openalex.org/W2124598893","https://openalex.org/W2126374403","https://openalex.org/W2147801509","https://openalex.org/W2148204785","https://openalex.org/W2151749258","https://openalex.org/W2159122914","https://openalex.org/W2161682643","https://openalex.org/W2168595161","https://openalex.org/W2319032954","https://openalex.org/W2335455113"],"related_works":["https://openalex.org/W1965984281","https://openalex.org/W2128728135","https://openalex.org/W7216764308","https://openalex.org/W2106568336","https://openalex.org/W2121969269","https://openalex.org/W179426532","https://openalex.org/W131800491","https://openalex.org/W2587528134","https://openalex.org/W1972935621","https://openalex.org/W20102889"],"abstract_inverted_index":{"BACKGROUND:":[0],"Virtual":[1],"histology":[2],"(VH)":[3],"uses":[4],"intravascular":[5],"ultrasound":[6],"(IVUS)":[7],"radiofrequency":[8],"spectral":[9],"analysis":[10],"to":[11,23,57],"locally":[12],"identify":[13],"the":[14,27,68,114],"morphology":[15],"and":[16,35,92,134,140],"composition":[17],"of":[18,113,138,147,153,169],"atherosclerotic":[19],"plaques.":[20,150],"We":[21],"sought":[22],"explore":[24],"in":[25,38,65],"vivo":[26],"relation":[28],"between":[29],"IVUS-derived":[30,104],"thin":[31,105],"cap":[32,106],"fibro-atheroma":[33,107],"(IDTCFA)":[34,108],"remodelling":[36,141],"index":[37,142],"patients":[39,50],"with":[40,67,72,121,129],"acute":[41],"coronary":[42],"syndromes":[43],"using":[44],"IVUS-VH.":[45],"METHODS":[46],"AND":[47],"RESULTS:":[48],"Twenty-one":[49],"(63":[51],"vessels)":[52],"were":[53,102],"enrolled.":[54],"When":[55],"compared":[56],"cross":[58],"sectional":[59],"areas":[60],"(CSAs)":[61],"without":[62],"necrotic":[63,85],"core":[64,86],"contact":[66],"lumen":[69],"(NCCL),":[70],"CSAs":[71,120],"NCCL":[73,122],"had":[74,116,123],"a":[75,144,166],"larger":[76],"plaque":[77],"burden":[78],"42.8+/-11.5%":[79],"vs.":[80,89,96],"32.8+/-11.5%,":[81],"p<0.001;":[82],"higher":[83],"overall":[84],"content":[87],"[13.8+/-10.7%":[88],"2.3+/-7.9%":[90],"(p<0.001)]":[91],"calcified":[93],"tissue":[94],"[4.7+/-6.5":[95],"0.66+/-2.1%":[97],"(p<0.001)].":[98],"On":[99],"average":[100],"there":[101],"2":[103],"per":[109],"patient.":[110],"Nearly":[111],"half":[112],"IDTCFAs":[115],"positive":[117],"remodelling.":[118],"CONCLUSIONS:":[119],"worse":[124],"morphological":[125],"profiles":[126],"than":[127],"those":[128],"no":[130],"NCCL.":[131],"The":[132,151],"simultaneous":[133],"more":[135],"detailed":[136],"assessment":[137],"IDTCFA":[139],"identifies":[143],"reduced":[145],"number":[146],"allegedly":[148],"high-risk":[149,172],"findings":[152],"this":[154],"study":[155],"may":[156],"have":[157],"important":[158],"clinical":[159],"implications,":[160],"since":[161],"they":[162],"shed":[163],"light":[164],"into":[165],"possible":[167],"method":[168],"identiying":[170],"potentially":[171],"plaques":[173],"suitable":[174],"for":[175],"pharmacological":[176],"and/or":[177],"local":[178],"treatment.":[179]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}