{"id":"https://openalex.org/W2324677455","doi":"https://doi.org/10.1158/1538-7445.am2013-3816","title":"Abstract 3816: DNA variation at BARD1 predicts response to aurora kinase inhibition in neuroblastoma.","display_name":"Abstract 3816: DNA variation at BARD1 predicts response to aurora kinase inhibition in neuroblastoma.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2324677455","doi":"https://doi.org/10.1158/1538-7445.am2013-3816","mag":"2324677455"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-3816","doi":"https://doi.org/10.1158/1538-7445.am2013-3816","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3816","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012304523","display_name":"Vanessa Pineros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa M. Pineros","raw_affiliation_strings":["1University of Pennsylvania, Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Pennsylvania, Philadelphia, PA;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019056686","display_name":"Kristopher R. Bosse","orcid":"https://orcid.org/0000-0002-1424-2858","observed_orcids":["https://orcid.org/0000-0002-1424-2858"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kris R. Bosse","raw_affiliation_strings":["2Children's Hospital of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Children's Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008979088","display_name":"Lori S. Hart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori S. Hart","raw_affiliation_strings":["2Children's Hospital of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Children's Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064372210","display_name":"Sharon J. Diskin","orcid":"https://orcid.org/0000-0002-7200-8939","observed_orcids":["https://orcid.org/0000-0002-7200-8939","https://orcid.org/0000-0003-2171-3627"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon J. Diskin","raw_affiliation_strings":["2Children's Hospital of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Children's Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034411606","display_name":"JulieAnn Rader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JulieAnn Rader","raw_affiliation_strings":["2Children's Hospital of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Children's Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["2Children's Hospital of Philadelphia, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Children's Hospital of Philadelphia, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"3816","last_page":"3816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bard1","display_name":"BARD1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.8159999847412109},{"id":"https://openalex.org/keywords/aurora-b-kinase","display_name":"Aurora B kinase","score":1.0},{"id":"https://openalex.org/keywords/mln8237","display_name":"MLN8237","score":0.9419999718666077},{"id":"https://openalex.org/keywords/azd1152","display_name":"AZD1152","score":0.9850000143051147},{"id":"https://openalex.org/keywords/risk-haplotype","display_name":"risk haplotype","score":0.625},{"id":"https://openalex.org/keywords/dna-variation","display_name":"DNA variation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.5849999785423279},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.460999995470047},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8050000071525574},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.640999972820282},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.6610000133514404},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7807958722114563},{"id":"https://openalex.org/C2780808130","wikidata":"https://www.wikidata.org/wiki/Q24745285","display_name":"Aurora kinase","level":4,"score":0.6742591261863708},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6133738160133362},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5772554278373718},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5702425241470337},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5429688096046448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.531412661075592},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48493388295173645},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4749752879142761},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40428003668785095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36458998918533325},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30274850130081177},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.27003544569015503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21470874547958374},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.17176038026809692}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-3816","doi":"https://doi.org/10.1158/1538-7445.am2013-3816","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-3816","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168064716","https://openalex.org/W2122742535","https://openalex.org/W2338997872","https://openalex.org/W2999472304","https://openalex.org/W4399638036","https://openalex.org/W7097796457","https://openalex.org/W2027057177","https://openalex.org/W3047221384","https://openalex.org/W4404689790","https://openalex.org/W7047934150"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Neuroblastoma":[2],"remains":[3],"responsible":[4],"for":[5,103,379,443],"a":[6,73,101,107,125,159,166,174,199,210,221,321,327,346],"disproportionately":[7],"high":[8],"number":[9],"of":[10,52,127,212,268,279,308,323,348,364,374,385,434,439],"pediatric":[11],"cancer":[12],"deaths,":[13],"necessitating":[14],"novel":[15],"treatment":[16],"approaches.":[17],"Our":[18],"lab":[19],"has":[20],"previously":[21],"reported":[22],"DNA":[23,390,419],"variations":[24],"in":[25,40,72,97,124,183,185,209,216,259,273,326,334,376,429],"the":[26,283,287,330,342,354,371,386,435,440],"BRCA1-associated":[27],"RING":[28],"domain":[29],"1":[30],"(BARD1)":[31],"gene":[32],"to":[33,87,89,344,360,425],"be":[34,345,361],"significantly":[35,292],"associated":[36,61],"with":[37,58,198,227,247,256,286,296],"high-risk":[38,380],"neuroblastoma":[39,98,128,188,217,280,335,381,395],"an":[41,53,186],"ongoing":[42],"genome-wide":[43],"association":[44],"study":[45],"(Capasso":[46],"Nat":[47],"Gen":[48],"2009).":[49],"The":[50,155],"expression":[51],"oncogenic":[54],"isoform,":[55],"BARD1\u03b2,":[56],"correlated":[57],"this":[59,83,297],"disease":[60],"common":[62],"variation,":[63],"and":[64,90,95,106,119,147,172,178,193,265,302,312,358,382,397],"isoform":[65,84],"specific":[66],"depletion":[67,236],"showed":[68,237,281],"differential":[69],"growth":[70,137,214,228,239,309],"inhibition":[71,215,229,240,255,428],"risk":[74,134,223,289],"haplotype":[75,290],"dependent":[76],"manner":[77],"(Bosse":[78],"Can":[79],"Res":[80,455],"2012).":[81],"Furthermore,":[82],"was":[85,138,150,196,250],"shown":[86],"bind":[88],"stabilized":[91],"aurora":[92,161,168,331,349,426],"kinase":[93,162,169,176,254,332,350,427],"A":[94,163,177,253],"B":[96,170,179],"cells,":[99,336],"suggesting":[100,337],"mechanism":[102],"its":[104],"oncogenicity":[105,396],"potential":[108,343],"therapeutic":[109,398],"strategy.":[110],"Methods:":[111],"Short":[112],"interfering":[113],"RNAs":[114],"(siRNAs)":[115],"targeting":[116],"AURKA,":[117],"AURKB":[118,206],"BARD1\u03b2":[120,231],"were":[121,181,304],"tested":[122,182],"individually":[123],"panel":[126,191],"cell":[129,143,189,194,218,284],"lines":[130,219,285],"(n=8)":[131],"stratified":[132],"by":[133,140,152,388],"haplotype.":[135],"Cell":[136,202],"measured":[139,197],"real":[141],"time":[142],"electronic":[144],"sensing":[145],"(RT-CES),":[146],"mRNA":[148],"knockdown":[149,207,232],"confirmed":[151],"quantitative":[153],"PCR.":[154],"pharmacologic":[156],"inhibitors":[157,307],"MLN8237,":[158],"selective":[160,167],"inhibitor;":[164,171],"AZD1152,":[165],"CCT137690,":[173],"pan-aurora":[175],"inhibitor":[180,351],"vitro":[184],"expanded":[187],"line":[190],"(n=10),":[192],"viability":[195],"CellTiter-Glo(R)":[200],"Luminescent":[201],"Viability":[203],"Assay.":[204],"Results:":[205],"resulted":[208,258],"trend":[211],"greater":[213,293],"harboring":[220],"BARD1":[222,248,288,324,339,393,422],"haplotype,":[224],"directly":[225],"correlating":[226],"following":[230],"(R2=0.57,":[233],"p=0.03).":[234],"AURKA":[235],"significant":[238,260],"(mean":[241],"inhibition=45%,":[242],"p<0.0001),":[243],"but":[244,353],"no":[245],"correlation":[246],"genotype":[249],"observed.":[251],"Aurora":[252],"MLN8237":[257,272,375],"cytotoxicity":[261],"(IC50":[262,310],"30":[263],"-750nM),":[264],"further":[266,383],"analysis":[267],"published":[269],"studies":[270],"using":[271],"vivo":[274],"on":[275],"murine":[276],"xenograft":[277],"models":[278],"that":[282,338],"had":[291],"tumor":[294],"reduction":[295],"single":[298],"agent":[299],"therapy.":[300],"AZD1152":[301],"CCT137690":[303],"less":[305],"potent":[306],"30nM-10mM":[311],"250nM-3mM,":[313],"respectively).":[314],"Conclusion:":[315],"Taken":[316],"together,":[317],"these":[318],"data":[319,369],"support":[320,370],"model":[322],"acting":[325],"pathway":[328],"involving":[329],"proteins":[333],"genotypes":[340],"have":[341],"biomarker":[347],"activity,":[352],"associations":[355],"are":[356],"complex":[357],"unlikely":[359],"binary":[362],"predictors":[363],"sensitivity":[365],"or":[366],"insensitivity.":[367],"These":[368],"continued":[372],"investigation":[373],"clinical":[377],"trials":[378],"exploration":[384],"mechanisms":[387],"which":[389],"variation":[391,420],"at":[392,421],"influences":[394],"vulnerabilities.":[399],"Citation":[400],"Format:":[401],"Vanessa":[402],"M.":[403,417],"Pineros,":[404],"Kris":[405],"R.":[406],"Bosse,":[407],"Lori":[408],"S.":[409],"Hart,":[410],"Sharon":[411],"J.":[412],"Diskin,":[413],"JulieAnn":[414],"Rader,":[415],"John":[416],"Maris.":[418],"predicts":[423],"response":[424],"neuroblastoma.":[430],"[abstract].":[431],"In:":[432],"Proceedings":[433],"104th":[436],"Annual":[437],"Meeting":[438],"American":[441],"Association":[442],"Cancer":[444,454],"Research;":[445],"2013":[446],"Apr":[447],"6-10;":[448],"Washington,":[449],"DC.":[450],"Philadelphia":[451],"(PA):":[452],"AACR;":[453],"2013;73(8":[456],"Suppl):Abstract":[457],"nr":[458],"3816.":[459],"doi:10.1158/1538-7445.AM2013-3816":[460]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
