{"id":"https://openalex.org/W2324497269","doi":"https://doi.org/10.1097/00043426-199809000-00017","title":"Familial Neuroblastoma","display_name":"Familial Neuroblastoma","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2324497269","doi":"https://doi.org/10.1097/00043426-199809000-00017","mag":"2324497269","pmid":"https://pubmed.ncbi.nlm.nih.gov/9787327"},"language":"en","primary_location":{"id":"doi:10.1097/00043426-199809000-00017","doi":"https://doi.org/10.1097/00043426-199809000-00017","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-199809000-00017","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108566360","display_name":"Edrnond G. Lemire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Edrnond G. Lemire","raw_affiliation_strings":["Department of Pediatrics, University of Manitoba, Winnipeg, Canada","Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103495713","display_name":"Bernard N. Chodirker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bernard N. Chodirker","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112301970","display_name":"Gaynor J. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gaynor J. Williams","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lome E. Seargeant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lome E. Seargeant","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076330302","display_name":"Sara J. Israels","orcid":"https://orcid.org/0000-0002-1849-4825","observed_orcids":["https://orcid.org/0000-0002-1849-4825"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sara J. Israels","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015469970","display_name":"Susan Meredith Phillips","orcid":"https://orcid.org/0000-0001-7336-2190","observed_orcids":["https://orcid.org/0000-0001-7336-2190"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan M. Phillips","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097317345","display_name":"Joseph A. de Nanassy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joseph A. de Nanassy","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057096466","display_name":"Rochelle Yanofsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rochelle A. Yanofsky","raw_affiliation_strings":["Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Child Health (E.G.L., B.N.C., G.J.W., S.J.I., S.M.P., J.A.d.N., R.A.Y.). Human Genetics (E.G.L., B.N.C.), Pathology (G.J.W., S.M.P., J.A.d.N.). and Biochemistry & Molecular Biology (L.E.S.). University of Manitoba, Winnipeg. Manitoba. Canada, and from the Division of Oncology (J.M.M.), Children's Hospital of Philadelphia. Department of Pediatrics, University of Pennsylvania. School of Medicine, Philadelphia. Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I46247651"],"apc_list":null,"apc_paid":null,"fwci":0.1851,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57790406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"20","issue":"5","first_page":"489","last_page":"493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-neuroblastoma","display_name":"familial neuroblastoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/siblings","display_name":"siblings","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tumor-karyotype","display_name":"tumor karyotype","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mycn-amplification","display_name":"MYCN amplification","score":0.9729999899864197},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8679999709129333},{"id":"https://openalex.org/keywords/autologous-bone-marrow-transplantation","display_name":"autologous bone marrow transplantation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7110000252723694},{"id":"https://openalex.org/keywords/histologic-grade","display_name":"histologic grade","score":0.39800000190734863},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.8576632738113403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8065141439437866},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6581721305847168},{"id":"https://openalex.org/C2779879524","wikidata":"https://www.wikidata.org/wiki/Q23009870","display_name":"Cousin","level":2,"score":0.6487311124801636},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6339793801307678},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5501664876937866},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4472634196281433},{"id":"https://openalex.org/C2994180119","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Bone marrow transplantation","level":3,"score":0.4388326406478882},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4114189147949219},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34814655780792236},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31684839725494385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26892977952957153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17602401971817017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07684138417243958},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00043426-199809000-00017","doi":"https://doi.org/10.1097/00043426-199809000-00017","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-199809000-00017","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:9787327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9787327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G1886087413","display_name":"CHILDRENS CANCER GROUP","funder_award_id":"U10CA002649","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5775839071","display_name":null,"funder_award_id":"CA 60104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1484159661","https://openalex.org/W1520596966","https://openalex.org/W1926885922","https://openalex.org/W1963633345","https://openalex.org/W1965864793","https://openalex.org/W1981018952","https://openalex.org/W2002314852","https://openalex.org/W2042663854","https://openalex.org/W2043660620","https://openalex.org/W2059806511","https://openalex.org/W2073514689","https://openalex.org/W2084117694","https://openalex.org/W2085693449","https://openalex.org/W2087672457","https://openalex.org/W2088068686","https://openalex.org/W2089085922","https://openalex.org/W2090551435","https://openalex.org/W2096398040","https://openalex.org/W2107516467","https://openalex.org/W2118681164","https://openalex.org/W2149281955","https://openalex.org/W2270675550","https://openalex.org/W2420686437","https://openalex.org/W4238072967","https://openalex.org/W4245587302"],"related_works":["https://openalex.org/W2107516467","https://openalex.org/W2090551435","https://openalex.org/W1589959887","https://openalex.org/W2091650956","https://openalex.org/W1981018952","https://openalex.org/W2006983527","https://openalex.org/W2019439927","https://openalex.org/W2426773553","https://openalex.org/W2056108858","https://openalex.org/W6946244293"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"describe":[2],"the":[3,26,160,172],"clinical":[4,57,173],"and":[5,14,33,58,63,83,143,174],"biologic":[6,135],"features":[7],"of":[8,38,89,96,146,165,177],"neuroblastoma":[9],"(NB)":[10],"in":[11,25,43,101],"two":[12],"siblings":[13,27],"their":[15,44],"maternal":[16,45],"second":[17,46,102],"cousin.":[18],"PATIENTS":[19],"AND":[20],"METHODS:":[21],"NB":[22,40,82,110,132,150],"was":[23,41,52,138],"diagnosed":[24,42],"at":[28,66,153],"2":[29,105],"1/2":[30],"(patient":[31,35,48],"2)":[32],"5":[34],"3)":[36],"years":[37,54],"age.":[39],"cousin":[47],"1)":[49],"when":[50],"she":[51,92],"7":[53],"old.":[55],"Standard":[56],"biological":[59,175],"data,":[60],"tumor":[61,64,161],"karyotype,":[62],"allelotype":[65],"select":[67],"loci":[68],"were":[69],"obtained.":[70],"RESULTS:":[71],"Patient":[72,104,126],"1":[73,131],"had":[74,106,128],"International":[75],"Neuroblastoma":[76],"Staging":[77],"System":[78],"(INSS)":[79],"stage":[80,108,130],"4":[81,109],"unfavorable":[84,112],"histology":[85,113],"but":[86,114],"no":[87,115],"evidence":[88],"MYCN":[90,116],"amplification;":[91,117],"died":[93],"from":[94],"complications":[95],"autologous":[97],"bone":[98],"marrow":[99],"transplantation":[100],"remission.":[103],"INSS":[107,129],"with":[111,133,140],"her":[118],"disease":[119],"recurred":[120],"39":[121],"months":[122],"after":[123],"completing":[124],"therapy.":[125],"3":[127],"favorable":[134],"features;":[136],"he":[137],"treated":[139],"surgical":[141],"excision":[142],"remains":[144],"free":[145],"disease.":[147],"CONCLUSIONS:":[148],"Familial":[149],"may":[151],"occur":[152],"a":[154],"later":[155],"age":[156],"than":[157],"predicted":[158],"by":[159],"suppressor":[162],"gene":[163],"model":[164],"inherited":[166],"cancer.":[167],"This":[168],"report":[169],"further":[170],"emphasizes":[171],"heterogeneity":[176],"familial":[178],"NB.":[179]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}