{"id":"https://openalex.org/W2324445929","doi":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","title":"Phase I/II trial of dexverapamil, epirubicin, and granulocyte\u2010macrophage\u2013colony stimulating factor in patients with advanced pancreatic adenocarcinoma","display_name":"Phase I/II trial of dexverapamil, epirubicin, and granulocyte\u2010macrophage\u2013colony stimulating factor in patients with advanced pancreatic adenocarcinoma","publication_year":1995,"publication_date":"1995-10-15","ids":{"openalex":"https://openalex.org/W2324445929","doi":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","mag":"2324445929","pmid":"https://pubmed.ncbi.nlm.nih.gov/8620409"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","doi":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110160669","display_name":"Gabriela Verena Kornek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Gabriela Kornek","raw_affiliation_strings":["Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010712142","display_name":"Markus Raderer","orcid":"https://orcid.org/0000-0002-3248-5802","observed_orcids":["https://orcid.org/0000-0002-3248-5802"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Markus Raderer","raw_affiliation_strings":["Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107891942","display_name":"Thomas Schenk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Schenk","raw_affiliation_strings":["Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111770002","display_name":"Johann Pidlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johann Pidlich","raw_affiliation_strings":["Department of Internal Medicine IV, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine IV, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110382858","display_name":"Franz Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Franz Schulz","raw_affiliation_strings":["Department of Surgery, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082697693","display_name":"Sebastian Globits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sebastian Globits","raw_affiliation_strings":["Department of Internal Medicine II, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023915588","display_name":"Christine Tetzner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Tetzner","raw_affiliation_strings":["Department of Internal Medicine Knoll AG, Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Knoll AG, Ludwigshafen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108460887","display_name":"Werner Scheithauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Werner Scheithauer","raw_affiliation_strings":["Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Vienna University Medical School, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110160669"],"corresponding_institution_ids":["https://openalex.org/I129774422","https://openalex.org/I76134821"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.4075,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62461554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"76","issue":"8","first_page":"1356","last_page":"1362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epirubicin","display_name":"epirubicin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9480000138282776},{"id":"https://openalex.org/keywords/advanced-pancreatic-adenocarcinoma","display_name":"advanced pancreatic adenocarcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/granulocytopenia","display_name":"granulocytopenia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.7070000171661377},{"id":"https://openalex.org/keywords/anthracycline-toxicity","display_name":"anthracycline toxicity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/partial-response","display_name":"partial response","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9171388149261475},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.9012050628662109},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6275660991668701},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6215828657150269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5634086728096008},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5121803283691406},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.46396955847740173},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.44364821910858154},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4421996474266052},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.44087308645248413},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4398946762084961},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4278353452682495},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33255401253700256},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1802058219909668},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.1667517125606537},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.10266274213790894},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","doi":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19951015)76:8<1356::aid-cncr2820760810>3.0.co;2-#","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8620409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8620409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W87974379","https://openalex.org/W220750778","https://openalex.org/W1927327874","https://openalex.org/W1936178215","https://openalex.org/W1958840615","https://openalex.org/W1965785314","https://openalex.org/W1967221808","https://openalex.org/W1981999275","https://openalex.org/W1986222466","https://openalex.org/W2007233235","https://openalex.org/W2014042680","https://openalex.org/W2024463580","https://openalex.org/W2036507961","https://openalex.org/W2041209857","https://openalex.org/W2043143197","https://openalex.org/W2049366618","https://openalex.org/W2059739143","https://openalex.org/W2068449934","https://openalex.org/W2080798894","https://openalex.org/W2085963665","https://openalex.org/W2087306564","https://openalex.org/W2097878215","https://openalex.org/W2104733808","https://openalex.org/W2162606005","https://openalex.org/W2183288147","https://openalex.org/W2223026985","https://openalex.org/W2230711222","https://openalex.org/W2308532732","https://openalex.org/W2507629633","https://openalex.org/W2615953705"],"related_works":["https://openalex.org/W2064791365","https://openalex.org/W1981617190","https://openalex.org/W7098685838","https://openalex.org/W2061286382","https://openalex.org/W2168667876","https://openalex.org/W7098681468","https://openalex.org/W2106642332","https://openalex.org/W2164949562","https://openalex.org/W2072834181","https://openalex.org/W2598395497"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,257],"purpose":[2],"of":[3,14,19,51,58,64,84,90,92,115,145,231,234,259,297],"this":[4,241,262,285,304],"study":[5,289],"was":[6,182,199,245,268],"to":[7,117,240,294,308],"determine":[8],"the":[9,20,52,139,209,279],"maximum":[10],"tolerated":[11],"dose":[12,26,63,83,89,103,124],"(MTD)":[13],"a":[15,62,88],"cytotoxic":[16],"regimen":[17,263,305],"consisting":[18],"second-generation":[21],"chemosensitizer":[22],"dexverapamil":[23],"(DVPM),":[24],"high":[25],"epirubicin,":[27],"and":[28,87,110,158,175,187,203,250,266,312],"recombinant":[29],"human":[30],"granulocyte-macrophage-colony":[31],"stimulating":[32],"factor":[33],"(GM-CSF)":[34],"in":[35,184,221,247,254,284,291],"pancreatic":[36,319],"carcinoma.":[37],"PATIENTS":[38],"AND":[39],"METHODS:":[40],"Twenty-eight":[41],"previously":[42],"untreated":[43],"patients":[44,119,160,190,236,317],"with":[45,80,142,154,194,208,264,318],"locally":[46],"advanced":[47],"or":[48,228],"metastatic":[49],"adenocarcinoma":[50],"pancreas":[53],"were":[54,106,120,128],"studied.":[55],"Treatment":[56,126],"consisted":[57],"oral":[59],"DVPM":[60,265],"at":[61,122,171],"1000-1200":[65],"mg/day":[66],"for":[67,148,261,316],"3":[68,131,272],"days,":[69],"epirubicin":[70,260],"administered":[71,95],"as":[72],"an":[73,81,143,310],"intravenous":[74],"bolus":[75],"injection":[76],"on":[77],"Day":[78,98],"2":[79],"initial":[82],"90":[85],"mg/m2,":[86,177],"GM-CSF":[91,267],"400":[93],"micrograms":[94],"subcutaneously":[96],"from":[97],"5s":[99],"through":[100],"14.":[101],"Epirubicin":[102],"escalation":[104],"levels":[105,172],"90,":[107],"105,":[108,173],"120":[109,146,269],"135":[111,176],"mg/m2.":[112],"Consecutive":[113],"cohorts":[114],"four":[116],"eight":[118],"planned":[121],"each":[123],"level.":[125],"cycles":[127],"repeated":[129],"every":[130,271],"weeks.":[132,273],"RESULTS:":[133],"Hematologic":[134],"toxicity,":[135],"specifically":[136],"granulocytopenia,":[137],"constituted":[138],"dose-limiting":[140],"toxicity":[141,198,223],"MTD":[144,258],"mg/m2":[147,270],"epirubicin.":[149],"Despite":[150],"routine":[151],"supportive":[152],"therapy":[153],"GM-CSF,":[155],"four,":[156],"two,":[157,185],"five":[159],"experienced":[161],"Grade":[162,179],"4":[163,180],"granulocytopenia":[164,181],"during":[165,191],"their":[166],"first":[167],"two":[168],"treatment":[169,314],"courses":[170,193],"120,":[174],"respectively.":[178],"observed":[183,246,283],"three,":[186],"one":[188],"additional":[189],"subsequent":[192],"these":[195,300],"levels.":[196],"Nonhematologic":[197],"uncommon,":[200],"generally":[201],"modest,":[202],"did":[204],"not":[205],"correlate":[206],"clearly":[207],"anthracycline":[210],"dose.":[211],"Dexverapamil-related":[212],"cardiovascular":[213],"symptoms":[214],"occurred":[215,253],"frequently,":[216],"but":[217],"they":[218],"never":[219],"resulted":[220],"serious":[222],"requiring":[224],"active":[225],"medical":[226],"intervention":[227],"permanent":[229],"discontinuation":[230],"therapy.":[232,242],"Nine":[233],"28":[235],"achieved":[237],"partial":[238],"responses":[239],"Stable":[243],"disease":[244],"nine":[248],"patients,":[249],"tumor":[251],"progress":[252],"10.":[255],"CONCLUSION:":[256],"Though":[274],"it":[275],"remains":[276],"uncertain":[277],"whether":[278],"encouraging":[280],"response":[281],"activity":[282],"disease-oriented":[286],"Phase":[287],"I":[288],"was,":[290],"fact,":[292],"due":[293],"successful":[295],"modulation":[296],"multidrug":[298],"resistance,":[299],"results":[301],"suggest":[302],"that":[303],"is":[306],"likely":[307],"be":[309,323],"effective":[311],"tolerable":[313],"strategy":[315],"cancer,":[320],"which":[321],"should":[322],"evaluated":[324],"further.":[325]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
