{"id":"https://openalex.org/W2324259686","doi":"https://doi.org/10.1021/ar300007k","title":"Molecular Duplexes with Encoded Sequences and Stabilities","display_name":"Molecular Duplexes with Encoded Sequences and Stabilities","publication_year":2012,"publication_date":"2012-05-14","ids":{"openalex":"https://openalex.org/W2324259686","doi":"https://doi.org/10.1021/ar300007k","mag":"2324259686","pmid":"https://pubmed.ncbi.nlm.nih.gov/22578061"},"language":"en","primary_location":{"id":"doi:10.1021/ar300007k","doi":"https://doi.org/10.1021/ar300007k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ar300007k","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088103200","display_name":"Bing Gong","orcid":"https://orcid.org/0000-0002-4155-9965","observed_orcids":["https://orcid.org/0000-0002-4155-9965"]},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Bing Gong","raw_affiliation_strings":["Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States, and College of Chemistry, Beijing Normal University, Beijing 100875, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States, and College of Chemistry, Beijing Normal University, Beijing 100875, China","institution_ids":["https://openalex.org/I25254941","https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088103200"],"corresponding_institution_ids":["https://openalex.org/I25254941","https://openalex.org/I63190737"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.6642,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.89855948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"45","issue":"12","first_page":"2077","last_page":"2087"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.31839999556541443,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sequence-specificity","display_name":"sequence specificity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/duplex-stability","display_name":"duplex stability","score":0.7459999918937683},{"id":"https://openalex.org/keywords/supramolecular-chemistry","display_name":"supramolecular chemistry","score":0.6710000038146973},{"id":"https://openalex.org/keywords/dynamic-covalent-chemistry","display_name":"dynamic covalent chemistry","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.7139999866485596},{"id":"https://openalex.org/keywords/information-storage","display_name":"information storage","score":0.5450000166893005},{"id":"https://openalex.org/keywords/self-replication","display_name":"self-replication","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7212575674057007},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6696157455444336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5968265533447266},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5902813076972961},{"id":"https://openalex.org/C166950319","wikidata":"https://www.wikidata.org/wiki/Q245031","display_name":"Intermolecular force","level":3,"score":0.5765506029129028},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.5686181783676147},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4871315658092499},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.4622025489807129},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.4458320438861847},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4449653625488281},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.43788689374923706},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.39390334486961365},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3609009385108948},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.34303927421569824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000577","descriptor_name":"Amides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ar300007k","doi":"https://doi.org/10.1021/ar300007k","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ar300007k","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},{"id":"pmid:22578061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22578061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of chemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1545373105","https://openalex.org/W1648880131","https://openalex.org/W1928201602","https://openalex.org/W1966304410","https://openalex.org/W1975877608","https://openalex.org/W1976483388","https://openalex.org/W1980834739","https://openalex.org/W1988653878","https://openalex.org/W1989193756","https://openalex.org/W1992629935","https://openalex.org/W1997380582","https://openalex.org/W1998097773","https://openalex.org/W2007434121","https://openalex.org/W2007830428","https://openalex.org/W2019814812","https://openalex.org/W2019822706","https://openalex.org/W2023511772","https://openalex.org/W2028448754","https://openalex.org/W2032673316","https://openalex.org/W2038161813","https://openalex.org/W2039985930","https://openalex.org/W2042145134","https://openalex.org/W2045410650","https://openalex.org/W2047791235","https://openalex.org/W2048740371","https://openalex.org/W2049617379","https://openalex.org/W2056417733","https://openalex.org/W2056492109","https://openalex.org/W2056497483","https://openalex.org/W2058090403","https://openalex.org/W2061203106","https://openalex.org/W2067667324","https://openalex.org/W2075206362","https://openalex.org/W2075560634","https://openalex.org/W2076399630","https://openalex.org/W2087711663","https://openalex.org/W2088265791","https://openalex.org/W2088380738","https://openalex.org/W2091804166","https://openalex.org/W2092617009","https://openalex.org/W2101869135","https://openalex.org/W2109196266","https://openalex.org/W2120018022","https://openalex.org/W2121959523","https://openalex.org/W2122248295","https://openalex.org/W2133969644","https://openalex.org/W2135983073","https://openalex.org/W2141038001","https://openalex.org/W2144777184","https://openalex.org/W2152084182","https://openalex.org/W2162288181","https://openalex.org/W2165400040","https://openalex.org/W2167330395","https://openalex.org/W2315442716","https://openalex.org/W2322848879","https://openalex.org/W2331084347","https://openalex.org/W2762132024","https://openalex.org/W2907227701","https://openalex.org/W2950918391","https://openalex.org/W3017190668","https://openalex.org/W3021577848"],"related_works":["https://openalex.org/W2762132024","https://openalex.org/W1987902397","https://openalex.org/W2951248780","https://openalex.org/W2007830428","https://openalex.org/W2792258492","https://openalex.org/W2049617379","https://openalex.org/W2315442716","https://openalex.org/W2091804166","https://openalex.org/W29804617","https://openalex.org/W2415257641"],"abstract_inverted_index":{"Through":[0],"specific":[1,70],"molecular":[2,28,60,319],"shapes":[3],"and":[4,14,36,38,54,66,109,134,157,180,183,202,206,229,236,254,274,299,315,345,355,360],"repeating":[5],"polymeric":[6],"sequences,":[7],"biomacromolecules":[8],"encode":[9,26],"information":[10,356],"about":[11],"both":[12,233],"structure":[13],"function.":[15],"Inspired":[16],"by":[17,280,303],"DNA":[18,172],"molecules,":[19],"we":[20,37,99,264,275,292],"have":[21,41,151,195,207,293,321],"conceived":[22],"a":[23,57,323],"strategy":[24],"to":[25,287],"linear":[27],"strands":[29,74,102,138],"with":[30,62,103,171],"sequences":[31,65,130,173],"that":[32,112,225,268],"specify":[33],"intermolecular":[34,191],"association,":[35],"our":[39,46],"collaborators":[40],"supported":[42],"this":[43,161,336,362],"idea":[44],"through":[45],"experimental":[47],"work.":[48],"This":[49],"Account":[50],"summarizes":[51],"the":[52,122,129,153,247,278,282,288,327,340,368],"design":[53],"development":[55,248,334],"of":[56,59,92,106,115,121,125,131,160,185,189,213,249,329,335,342,367],"class":[58],"duplexes":[61,166,194,220,267,296,320,351],"programmable":[63,176,313],"hydrogen-bonding":[64,142,181],"adjustable":[67],"stabilities.":[68],"The":[69,211],"system":[71,337,363],"involves":[72],"oligoamide":[73,101,137],"synthesized":[75],"from":[76,259],"readily":[77],"available":[78],"monomeric":[79],"modules":[80],"based":[81],"on":[82],"standard":[83],"amide":[84,107],"(peptide)":[85],"chemistry.":[86],"By":[87],"covalently":[88],"linking":[89],"three":[90],"types":[91],"basic":[93],"building":[94],"blocks":[95],"in":[96,232,305],"different":[97,271,330],"orders,":[98],"create":[100],"various":[104],"arrangements":[105],"O":[108],"H":[110],"atoms":[111],"provide":[113],"arrays":[114],"hydrogen":[116],"bonding":[117],"sequences.":[118],"Because":[119,349],"one":[120],"two":[123],"edges":[124,143],"these":[126,136,193,218,260,318,350],"molecules":[127,373],"presents":[128],"hydrogen-bond":[132],"donors":[133],"acceptors,":[135],"associate":[139],"via":[140],"their":[141,312],"into":[144,217],"double-stranded":[145],"pairs":[146],"or":[147],"duplexes.":[148,289],"Systematic":[149],"studies":[150],"demonstrated":[152],"strict":[154],"sequence":[155,177],"specificity":[156,314],"tunable":[158,316],"stability":[159],"system.":[162],"These":[163,241],"structurally":[164],"simple":[165],"exhibit":[167],"many":[168,343],"features":[169],"associated":[170],"such":[174,199,308],"as":[175,200,309],"specificity,":[178],"shape":[179],"complementarity,":[182],"cooperativity":[184],"multipoint":[186],"interactions.":[187],"Capable":[188],"specifying":[190],"associations,":[192],"formed":[196],"supramolecular":[197,344],"structures":[198],"\u03b2-sheets":[201],"non-covalent":[203],"block":[204],"copolymers":[205],"templated":[208],"chemical":[209],"reactions.":[210],"incorporation":[212],"dynamic":[214,251,346],"covalent":[215,230,252,347],"interactions":[216],"H-bonded":[219],"has":[221],"created":[222],"association":[223,228,243,328],"units":[224,244],"undergo":[226],"sequence-specific":[227],"ligation":[231],"nonpolar":[234],"solvents":[235],"polar":[237],"media":[238],"including":[239,374],"water.":[240],"new":[242,250,255],"may":[245,364],"facilitate":[246,339],"structures,":[253],"properties":[256],"are":[257,301,352],"emerging":[258],"structures.":[261,348],"For":[262],"example,":[263],"discovered":[265],"hydrogen-bonded":[266],"could":[269,276,338],"gelate":[270],"organic":[272],"solvents,":[273],"tune":[277],"gelatinization":[279],"adjusting":[281],"multiple":[283],"side":[284],"chains":[285],"attached":[286],"In":[290],"addition,":[291],"recently":[294],"designed":[295],"whose":[297],"formation":[298],"dissociation":[300],"controlled":[302],"changes":[304],"external":[306],"stimuli":[307],"acidity.":[310],"With":[311],"stability,":[317],"provided":[322],"systematic":[324],"approach":[325],"for":[326],"structural":[331],"units.":[332],"Further":[333],"creation":[341],"easily":[353,358],"modifiable":[354],"is":[357],"encoded":[359],"retrieved,":[361],"address":[365],"some":[366],"remaining":[369],"challenges":[370],"facing":[371],"information-storing":[372],"self-replication.":[375]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}