{"id":"https://openalex.org/W2323947334","doi":"https://doi.org/10.5588/ijtld.11.0591","title":"Hepatotoxicity during treatment for multidrug-resistant tuberculosis: occurrence, management and outcome","display_name":"Hepatotoxicity during treatment for multidrug-resistant tuberculosis: occurrence, management and outcome","publication_year":2012,"publication_date":"2012-03-09","ids":{"openalex":"https://openalex.org/W2323947334","doi":"https://doi.org/10.5588/ijtld.11.0591","mag":"2323947334","pmid":"https://pubmed.ncbi.nlm.nih.gov/22410436"},"language":"en","primary_location":{"id":"doi:10.5588/ijtld.11.0591","doi":"https://doi.org/10.5588/ijtld.11.0591","is_oa":false,"landing_page_url":"https://doi.org/10.5588/ijtld.11.0591","pdf_url":null,"source":{"id":"https://openalex.org/S124285728","display_name":"The International Journal of Tuberculosis and Lung Disease","issn_l":"1027-3719","issn":["1027-3719","1815-7920","1815-8439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319960","host_organization_name":"International Union Against Tuberculosis and Lung Disease","host_organization_lineage":["https://openalex.org/P4310319960"],"host_organization_lineage_names":["International Union Against Tuberculosis and Lung Disease"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Tuberculosis and Lung Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036947490","display_name":"Salmaan A. Keshavjee","orcid":"https://orcid.org/0000-0002-6967-3305","observed_orcids":["https://orcid.org/0000-0002-6967-3305"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Keshavjee","raw_affiliation_strings":["Program in Infectious Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA; Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Partners In Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Infectious Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA; Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Partners In Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I129364015","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113732411","display_name":"Irina Y. Gelmanova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Y. Gelmanova","raw_affiliation_strings":["Partners In Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners In Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I129364015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113840154","display_name":"S. S. Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I129364015","display_name":"Partners In Health","ror":"https://ror.org/05tsvnv68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I129364015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Shin","raw_affiliation_strings":["Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Partners In Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Partners In Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I129364015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043006783","display_name":"Sergey P. Mishustin","orcid":"https://orcid.org/0000-0002-4414-460X","observed_orcids":["https://orcid.org/0000-0002-4414-460X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. P. Mishustin","raw_affiliation_strings":["Tomsk Oblast Tuberculosis Services, Tomsk, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tomsk Oblast Tuberculosis Services, Tomsk, Russian Federation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073660878","display_name":"Yevgeny G Andreev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142077","display_name":"Federal Penitentiary Service","ror":"https://ror.org/03grptj54","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210142077"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Y. G. Andreev","raw_affiliation_strings":["Federal Penitentiary Services, Tomsk, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Penitentiary Services, Tomsk, Russian Federation","institution_ids":["https://openalex.org/I4210142077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110197983","display_name":"S. S. Atwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Atwood","raw_affiliation_strings":["Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026613536","display_name":"Jennifer Joan Furin","orcid":"https://orcid.org/0000-0002-0825-7199","observed_orcids":["https://orcid.org/0000-0002-0825-7199"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. Furin","raw_affiliation_strings":["Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074559834","display_name":"Ann C. Miller","orcid":"https://orcid.org/0000-0001-6841-9439","observed_orcids":["https://orcid.org/0000-0001-6841-9439"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Miller","raw_affiliation_strings":["Program in Infectious Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Infectious Disease and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7667,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.84753376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"5","first_page":"596","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tuberculosis-treatment","display_name":"tuberculosis treatment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.652999997138977},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.800000011920929},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.6320000290870667},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cavitary-lung-disease","display_name":"cavitary lung disease","score":0.8119999766349792},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7860000133514404},{"id":"https://openalex.org/keywords/prisoners","display_name":"prisoners","score":0.44200000166893005},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9699035882949829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7233520150184631},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6788671016693115},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6069940328598022},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5375956892967224},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.4210547208786011},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39342576265335083},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33039969205856323},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09446242451667786},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011329","descriptor_name":"Prisoners","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012426","descriptor_name":"Russia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5588/ijtld.11.0591","doi":"https://doi.org/10.5588/ijtld.11.0591","is_oa":false,"landing_page_url":"https://doi.org/10.5588/ijtld.11.0591","pdf_url":null,"source":{"id":"https://openalex.org/S124285728","display_name":"The International Journal of Tuberculosis and Lung Disease","issn_l":"1027-3719","issn":["1027-3719","1815-7920","1815-8439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319960","host_organization_name":"International Union Against Tuberculosis and Lung Disease","host_organization_lineage":["https://openalex.org/P4310319960"],"host_organization_lineage_names":["International Union Against Tuberculosis and Lung Disease"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Tuberculosis and Lung Disease","raw_type":"journal-article"},{"id":"pmid:22410436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22410436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W19265322","https://openalex.org/W38847137","https://openalex.org/W55019144","https://openalex.org/W84129908","https://openalex.org/W105185758","https://openalex.org/W105561674","https://openalex.org/W130933825","https://openalex.org/W154859743","https://openalex.org/W178009456","https://openalex.org/W197236811","https://openalex.org/W250539612","https://openalex.org/W1533412717","https://openalex.org/W1727821671","https://openalex.org/W1862890983","https://openalex.org/W1980259122","https://openalex.org/W1993371935","https://openalex.org/W1999481211","https://openalex.org/W2001879423","https://openalex.org/W2011688319","https://openalex.org/W2020976497","https://openalex.org/W2029308228","https://openalex.org/W2030398884","https://openalex.org/W2046744217","https://openalex.org/W2047966951","https://openalex.org/W2049250595","https://openalex.org/W2055394331","https://openalex.org/W2059308749","https://openalex.org/W2064303880","https://openalex.org/W2097385715","https://openalex.org/W2107408002","https://openalex.org/W2109028417","https://openalex.org/W2117634176","https://openalex.org/W2142085135","https://openalex.org/W2144362977","https://openalex.org/W2157712198","https://openalex.org/W2166822423","https://openalex.org/W2186379012","https://openalex.org/W2340894593","https://openalex.org/W2394686291","https://openalex.org/W2407512775","https://openalex.org/W2410681466","https://openalex.org/W2412840707","https://openalex.org/W2418254245","https://openalex.org/W2419445256","https://openalex.org/W2422498755","https://openalex.org/W2986697985","https://openalex.org/W2993404866"],"related_works":["https://openalex.org/W2049957653","https://openalex.org/W4312891188","https://openalex.org/W4410726802","https://openalex.org/W2905648245","https://openalex.org/W2368656143","https://openalex.org/W7051641261","https://openalex.org/W2406954073","https://openalex.org/W3035245480","https://openalex.org/W1994128062","https://openalex.org/W2126837816"],"abstract_inverted_index":{"SETTING:":[0],"Multidrug-resistant":[1],"tuberculosis":[2],"(MDR-TB)":[3],"treatment":[4,19,34,71,95,103,113,168,173],"program":[5],"in":[6,55,104,160,164,174,184,189],"Tomsk,":[7],"Russia.":[8],"OBJECTIVE:":[9],"To":[10],"describe":[11],"the":[12,63,175],"incidence":[13],"and":[14,22,31,87,101,120],"management":[15],"of":[16,20,177],"hepatotoxicity":[17,77,137,178],"during":[18,179],"MDR-TB,":[21],"to":[23,62],"assess":[24],"risk":[25],"factors":[26,74],"associated":[27,75,111,129,139],"with":[28,76,112,130,140],"its":[29],"development":[30],"impact":[32],"on":[33],"outcomes.":[35,132,191],"DESIGN:":[36],"A":[37],"retrospective":[38],"case":[39,166],"series":[40],"performed":[41],"among":[42],"608":[43],"patients.":[44],"RESULTS:":[45],"Hepatotoxicity,":[46],"using":[47],"American":[48],"Thoracic":[49],"Society":[50],"(2006)":[51],"definitions,":[52],"was":[53,67,138,167],"observed":[54],"91/568":[56],"patients":[57],"(16.5%).":[58],"The":[59],"median":[60],"time":[61],"first":[64],"hepatotoxic":[65],"event":[66],"196":[68],"days":[69],"post":[70],"commencement.":[72],"Baseline":[73],"included":[78],"elevated":[79],"alanine":[80],"aminotransferase/aspartate":[81],"aminotransferase/bilirubin":[82],"(OR":[83,90,97,106,116,124,143,149],"53.9,":[84],"95%CI":[85,92,99,108,118,126,145,151],"6.30-438.7),":[86],"renal":[88],"insufficiency":[89],"19.6,":[91],"2.71-141.6).":[93],"High":[94],"adherence":[96],"3.25,":[98],"2.07-5.09)":[100],"starting":[102],"prison":[105],"1.77,":[107],"1.04-3.01)":[109],"were":[110,128,157],"success.":[114],"Smoking":[115],"0.44,":[117],"0.21-0.92)":[119],"bilateral":[121],"cavitary":[122],"disease":[123],"0.51,":[125],"0.34-0.77)":[127],"worse":[131],"For":[133],"alcohol":[134],"users,":[135],"developing":[136],"better":[141],"outcomes":[142],"4.40,":[144],"1.79-10.81)":[146],"than":[147],"not":[148,182],"0.42,":[150],"0.25-0.68).":[152],"One":[153],"or":[154],"more":[155],"medications":[156],"permanently":[158],"stopped":[159],"10/91":[161],"patients,":[162],"but":[163],"no":[165],"entirely":[169],"discontinued.":[170],"CONCLUSION:":[171],"MDR-TB":[172],"face":[176],"therapy":[180],"did":[181],"result":[183],"a":[185],"statistically":[186],"significant":[187],"increase":[188],"poor":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
