{"id":"https://openalex.org/W2323792000","doi":null,"title":"Synthesis and evaluation of a 99mTechnetium labeled chitin-binding protein as potential specific radioligand for the detection of fungal infections in mice.","display_name":"Synthesis and evaluation of a 99mTechnetium labeled chitin-binding protein as potential specific radioligand for the detection of fungal infections in mice.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2323792000","mag":"2323792000","pmid":"https://pubmed.ncbi.nlm.nih.gov/16868531"},"language":"en","primary_location":{"id":"pmid:16868531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16868531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025760331","display_name":"R Siaens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R Siaens","raw_affiliation_strings":["Laboratory of Radiopharmacy, Gent University, Gent, Belgium. Rien.Siaens@ugent.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Radiopharmacy, Gent University, Gent, Belgium. Rien.Siaens@ugent.be","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114252377","display_name":"Vgh Eijsink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V G H Eijsink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014109932","display_name":"Gustav Vaaje\u2010Kolstad","orcid":"https://orcid.org/0000-0002-3077-8003","observed_orcids":["https://orcid.org/0000-0002-3077-8003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Vaaje-Kolstad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068582590","display_name":"K Vandenbulcke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Vandenbulcke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013266190","display_name":"Bart T. Cornelissen","orcid":"https://orcid.org/0000-0001-7581-3303","observed_orcids":["https://orcid.org/0000-0001-7581-3303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Cornelissen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108412708","display_name":"Claude A Cuvelier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Cuvelier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019778216","display_name":"Rudi Dierckx","orcid":"https://orcid.org/0000-0003-4971-2909","observed_orcids":["https://orcid.org/0000-0003-4971-2909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Dierckx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109951288","display_name":"Guido Slegers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Slegers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2309,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.58960703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"50","issue":"3","first_page":"155","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitin-binding-protein","display_name":"chitin-binding protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.9860000014305115},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.6660000085830688},{"id":"https://openalex.org/keywords/radioligands","display_name":"radioligands","score":0.6830000281333923},{"id":"https://openalex.org/keywords/chitin","display_name":"chitin","score":0.4399999976158142},{"id":"https://openalex.org/keywords/immunodeficient-mice","display_name":"immunodeficient mice","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.671999990940094},{"id":"https://openalex.org/keywords/beta-chitin","display_name":"\u03b2-chitin","score":0.6060000061988831},{"id":"https://openalex.org/keywords/radionuclide-imaging","display_name":"scintigraphy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.8533079624176025},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7353319525718689},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.576248824596405},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.5509700179100037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5181264281272888},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.47427067160606384},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.45860016345977783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3749174177646637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36154526472091675},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3559954762458801},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.13544198870658875},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.0767667293548584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:16868531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16868531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:364605","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-364605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1824-4661","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/724a7f7c-8198-41e1-a9dc-f1878150ad1e","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/synthesis-and-evaluation-of-a-99mtechnetium-labeled-chitinbinding-protein-as-potential-specific-radioligand-for-the-detection-of-fungal-infections-in-mice(724a7f7c-8198-41e1-a9dc-f1878150ad1e).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quarterly Journal of Nuclear Medicine and Molecular Imaging. EDIZIONI MINERVA MEDICA","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2323792000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16868531","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2106893379","https://openalex.org/W2026218983","https://openalex.org/W3042334210","https://openalex.org/W2045228590","https://openalex.org/W2165517499","https://openalex.org/W2166712052","https://openalex.org/W4407132173","https://openalex.org/W1913783447","https://openalex.org/W4390881784","https://openalex.org/W2319315650"],"abstract_inverted_index":{"AIM:":[0],"Radiopharmaceuticals":[1],"can":[2],"be":[3],"used":[4],"to":[5,12,41,178,183,255,273,282],"exploit":[6],"differences":[7],"between":[8],"microorganisms":[9,94],"in":[10,20,29,110,118,167,216,230,240,260,265,292],"order":[11],"distinguish":[13,274],"fungal":[14,43,69,116,191,217,275,294],"from":[15,57,277],"bacterial":[16,32,114,194,231,278],"infection.":[17,44],"Chitin,":[18],"abundant":[19],"the":[21,51,65,106,119,147,209,214,235,241,287,290,293],"cell":[22,295],"wall":[23],"of":[24,53,67,105,146,157,163,190,208,213,237,286],"fungi,":[25],"is":[26,253,271],"not":[27],"present":[28],"mammalian":[30],"or":[31,234],"cells":[33],"and":[34,80,93,115,121,131,142,159,200,204,263],"therefore":[35],"represents":[36],"a":[37,61,154,160,283],"highly":[38],"specific":[39,62,161,284],"target":[40],"localize":[42],"In":[45,85,102,186],"this":[46],"study,":[47],"we":[48],"have":[49],"examined":[50],"potential":[52],"chitin-binding":[54],"protein":[55,288],"(CBP21)":[56],"Serratia":[58],"marcescens":[59],"as":[60,96,98,128,133],"radiotracer":[63],"for":[64],"detection":[66],"invasive":[68],"infections.":[70],"METHODS:":[71],"CBP21":[72],"was":[73,108,151,223],"labeled":[74,152],"with":[75,89,113,153,173,258,289],"99mTc":[76],"via":[77],"hydrazinonicotinamide":[78],"(HYNIC)":[79],"its":[81],"characteristics":[82],"were":[83,100,138,171,180,196],"analyzed.":[84],"vitro":[86,168],"binding":[87,169],"studies":[88],"polymorphic":[90],"chitin":[91,259,291],"forms":[92],"(fungi":[95],"well":[97],"bacteria)":[99],"performed.":[101],"vivo":[103,266],"biodistribution":[104],"compound":[107],"studied":[109],"immunocompromised":[111],"mice":[112],"infections":[117,218,232,243],"left":[120],"right":[122],"thigh":[123],"muscle,":[124],"respectively,":[125,245],"using":[126],"99mTc-HYNIC-myoglobin":[127,238],"size-matched":[129],"control":[130],"67Ga-citrate":[132],"positive":[134],"control.":[135],"Scintigraphic":[136],"images":[137],"acquired":[139],"at":[140,198,220],"1":[141],"7":[143,201,221],"h":[144,202,222],"postinjection":[145,207],"tracer.":[148,210],"RESULTS:":[149],"99mTc-HYNIC-CBP21":[150,252,270],"radiochemical":[155],"yield":[156],"61%":[158],"activity":[162],"22.3":[164],"MBq/nmol.":[165],"Highest":[166],"percentages":[170],"found":[172],"beta-chitin":[174],"(86.8+/-2.4%).":[175],"Binding":[176],"interactions":[177],"fungi":[179],"higher":[181,226],"than":[182,227],"bacteria":[184],"(P<0.05).":[185],"vivo,":[187],"best":[188],"ratios":[189],"infection":[192,195,276,279],"versus":[193],"seen":[197,229],"5":[199],"(3.6+/-1.2":[203],"2.9+/-1.4,":[205],"respectively)":[206],"Maximum":[211],"uptake":[212,228,236],"tracer":[215],"(0.63+/-0.11%ID/g)":[219],"significantly":[224],"(P<0.05)":[225,239],"(0.34+/-0.11%ID/g)":[233],"same":[242],"(0.35+/-0.11%ID/g,":[244],"0.3+/-0.01%ID/g).":[246],"CONCLUSIONS:":[247],"This":[248],"study":[249],"shows":[250],"that":[251,269],"able":[254,272],"specifically":[256],"interact":[257],"vitro.":[261],"Scintigraphy":[262],"postmortem":[264],"data":[267],"indicate":[268],"probably":[280],"due":[281],"interaction":[285],"wall.":[296]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}