{"id":"https://openalex.org/W2323596237","doi":"https://doi.org/10.1021/jf204062p","title":"Plant Extracts, Spices, and Essential Oils Inactivate Escherichia coli O157:H7 and Reduce Formation of Potentially Carcinogenic Heterocyclic Amines in Cooked Beef Patties","display_name":"Plant Extracts, Spices, and Essential Oils Inactivate Escherichia coli O157:H7 and Reduce Formation of Potentially Carcinogenic Heterocyclic Amines in Cooked Beef Patties","publication_year":2012,"publication_date":"2012-03-07","ids":{"openalex":"https://openalex.org/W2323596237","doi":"https://doi.org/10.1021/jf204062p","mag":"2323596237","pmid":"https://pubmed.ncbi.nlm.nih.gov/22397498"},"language":"en","primary_location":{"id":"doi:10.1021/jf204062p","doi":"https://doi.org/10.1021/jf204062p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf204062p","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113531483","display_name":"Liliana Rounds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liliana Rounds","raw_affiliation_strings":["Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037095537","display_name":"Cody M. Havens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody M. Havens","raw_affiliation_strings":["Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048464705","display_name":"Yelena Feinstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yelena Feinstein","raw_affiliation_strings":["Center for Toxicology, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000605266","display_name":"Mendel Friedman","orcid":"https://orcid.org/0000-0003-2582-7517","observed_orcids":["https://orcid.org/0000-0003-2582-7517"]},"institutions":[{"id":"https://openalex.org/I4210140558","display_name":"Western Regional Research Center","ror":"https://ror.org/03x7fn667","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210094889","https://openalex.org/I4210140558"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mendel Friedman","raw_affiliation_strings":["USDA-ARS Western Regional Research Center, Albany, California 94710, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USDA-ARS Western Regional Research Center, Albany, California 94710, United States","institution_ids":["https://openalex.org/I4210140558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111516499","display_name":"Sadhana Ravishankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sadhana Ravishankar","raw_affiliation_strings":["Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111516499"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":10.8058,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.98504636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"60","issue":"14","first_page":"3792","last_page":"3799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.08940000087022781,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10900","display_name":"Listeria monocytogenes in Food Safety","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli-o157-h7","display_name":"Escherichia coli O157:H7","score":0.9879999756813049},{"id":"https://openalex.org/keywords/heterocyclic-amines","display_name":"heterocyclic amines","score":0.9739999771118164},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.8989999890327454},{"id":"https://openalex.org/keywords/spices","display_name":"spices","score":0.9549999833106995},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":1.0},{"id":"https://openalex.org/keywords/lemongrass-oil","display_name":"lemongrass essential oil","score":0.9850000143051147},{"id":"https://openalex.org/keywords/clove-bud-oil","display_name":"clove bud oil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/onion-powder","display_name":"onion powder","score":0.9900000095367432},{"id":"https://openalex.org/keywords/meiqx","display_name":"MeIQx","score":0.7620000243186951},{"id":"https://openalex.org/keywords/phip","display_name":"PhIP","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foodborne-pathogen-inactivation","display_name":"foodborne pathogen inactivation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/natural-antimicrobials","display_name":"natural antimicrobials","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7360368371009827},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.714194118976593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6551679372787476},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6521760821342468},{"id":"https://openalex.org/C34135077","wikidata":"https://www.wikidata.org/wiki/Q3511075","display_name":"Food contaminant","level":2,"score":0.43398919701576233},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18824177980422974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1730727255344391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008460","descriptor_name":"Meat","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008460","descriptor_name":"Meat","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009822","descriptor_name":"Oils, Volatile","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017365","descriptor_name":"Spices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019453","descriptor_name":"Escherichia coli O157","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019697","descriptor_name":"Onions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027845","descriptor_name":"Malus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031658","descriptor_name":"Olea","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045783","descriptor_name":"Clove Oil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jf204062p","doi":"https://doi.org/10.1021/jf204062p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf204062p","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:22397498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22397498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W142928279","https://openalex.org/W1530156780","https://openalex.org/W1968611149","https://openalex.org/W1969495202","https://openalex.org/W1973463089","https://openalex.org/W1973717075","https://openalex.org/W1976121644","https://openalex.org/W1978034643","https://openalex.org/W1978671440","https://openalex.org/W1982596382","https://openalex.org/W1983775809","https://openalex.org/W1985158862","https://openalex.org/W1990876232","https://openalex.org/W1991021772","https://openalex.org/W2003347299","https://openalex.org/W2003636707","https://openalex.org/W2003782759","https://openalex.org/W2006575211","https://openalex.org/W2008368893","https://openalex.org/W2008931521","https://openalex.org/W2021404317","https://openalex.org/W2022288992","https://openalex.org/W2022681026","https://openalex.org/W2033541343","https://openalex.org/W2037031967","https://openalex.org/W2040649114","https://openalex.org/W2041449410","https://openalex.org/W2042739132","https://openalex.org/W2044124786","https://openalex.org/W2047236831","https://openalex.org/W2047318806","https://openalex.org/W2052404589","https://openalex.org/W2054673675","https://openalex.org/W2058095783","https://openalex.org/W2059956794","https://openalex.org/W2069866651","https://openalex.org/W2071346555","https://openalex.org/W2075645489","https://openalex.org/W2078855755","https://openalex.org/W2080049984","https://openalex.org/W2084704876","https://openalex.org/W2086568028","https://openalex.org/W2088033673","https://openalex.org/W2089300758","https://openalex.org/W2089556198","https://openalex.org/W2092517644","https://openalex.org/W2092743709","https://openalex.org/W2094326888","https://openalex.org/W2095080873","https://openalex.org/W2109590577","https://openalex.org/W2109672273","https://openalex.org/W2112852047","https://openalex.org/W2115552120","https://openalex.org/W2120969531","https://openalex.org/W2126363307","https://openalex.org/W2127321206","https://openalex.org/W2128636335","https://openalex.org/W2139252765","https://openalex.org/W2144963709","https://openalex.org/W2152180052","https://openalex.org/W2156581772","https://openalex.org/W2159548036","https://openalex.org/W2164041166","https://openalex.org/W2169151520","https://openalex.org/W2248853836","https://openalex.org/W2317729965","https://openalex.org/W2341142949","https://openalex.org/W2463976292"],"related_works":["https://openalex.org/W1975357936","https://openalex.org/W1968611149","https://openalex.org/W2040777555","https://openalex.org/W2291670117","https://openalex.org/W3021854170","https://openalex.org/W4401121976","https://openalex.org/W2126363307","https://openalex.org/W2643618401","https://openalex.org/W4224281437","https://openalex.org/W2265646266"],"abstract_inverted_index":{"Meats":[0],"need":[1],"to":[2,5,17,40,70,125,144,229],"be":[3],"heated":[4,51],"inactivate":[6,42],"foodborne":[7,231],"pathogens":[8],"such":[9],"as":[10,233,235],"Escherichia":[11],"coli":[12,44,63,103,122,142],"O157:H7.":[13],"High-temperature":[14],"treatment":[15],"used":[16],"prepare":[18],"well-done":[19],"meats":[20],"increases":[21],"the":[22,31,75,127,153,172,227],"formation":[23,49,213],"of":[24,33,94,113,174,209,214],"carcinogenic":[25],"heterocyclic":[26,161],"amines":[27,162],"(HCAs).":[28],"We":[29],"evaluated":[30],"ability":[32],"plant":[34,224],"extracts,":[35],"spices,":[36],"and":[37,46,79,90,130,165,179,181,187,199,205],"essential":[38],"oils":[39],"simultaneously":[41],"E.":[43,62,102,121,141],"O157:H7":[45,64,123,143],"suppress":[47],"HCA":[48,105],"in":[50,237],"hamburger":[52],"patties.":[53],"Ground":[54],"beef":[55],"with":[56,61,171,182,194],"added":[57],"antimicrobials":[58],"was":[59],"inoculated":[60],"(10(7)":[65],"CFU/g).":[66],"Patties":[67],"were":[68,85,98,168,192,201],"cooked":[69,80],"reach":[71],"45":[72],"\u00b0C":[73],"at":[74],"geometric":[76],"center,":[77],"flipped,":[78],"for":[81,88],"5":[82],"min.":[83],"Samples":[84],"then":[86],"taken":[87],"microbiological":[89],"mass":[91],"spectrometry":[92],"analysis":[93],"HCAs.":[95],"Some":[96],"compounds":[97,225],"inhibitory":[99],"only":[100],"against":[101],"or":[104,116],"formation,":[106],"while":[107,148],"some":[108],"others":[109],"inhibited":[110],"both.":[111],"Addition":[112,208],"5%":[114],"olive":[115,175],"apple":[117,183],"skin":[118],"extracts":[119],"reduced":[120,140,152,170,202],"populations":[124],"below":[126,145],"detection":[128,146],"limit":[129],"by":[131,155,177,185,203,216],"1.6":[132,156],"log":[133,157],"CFU/g,":[134],"respectively.":[135,189,207],"Similarly,":[136],"1%":[137],"lemongrass":[138],"oil":[139,151],"limits,":[147],"clove":[149,195],"bud":[150,196],"pathogen":[154],"CFU/g.":[158],"The":[159],"major":[160],"2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline":[163],"(MeIQx)":[164],"2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine":[166],"(PhIP)":[167],"concurrently":[169],"addition":[173],"extract":[176,184],"79.5%":[178],"84.3%":[180],"76.1%":[186],"82.1%,":[188],"Similar":[190],"results":[191,219],"observed":[193],"oil:":[197],"MeIQx":[198],"PhIP":[200,215],"35%":[204],"52.1%,":[206],"onion":[210],"powder":[211],"decreased":[212],"94.3%.":[217],"These":[218],"suggest":[220],"that":[221],"edible":[222],"natural":[223],"have":[226],"potential":[228],"prevent":[230],"infections":[232],"well":[234],"carcinogenesis":[236],"humans":[238],"consuming":[239],"heat-processed":[240],"meat":[241],"products.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
