{"id":"https://openalex.org/W2323219986","doi":"https://doi.org/10.1021/ac503677d","title":"Calorimetric Markers of Bence Jones and Nonsecretory Multiple Myeloma Serum Proteome","display_name":"Calorimetric Markers of Bence Jones and Nonsecretory Multiple Myeloma Serum Proteome","publication_year":2014,"publication_date":"2014-11-26","ids":{"openalex":"https://openalex.org/W2323219986","doi":"https://doi.org/10.1021/ac503677d","mag":"2323219986","pmid":"https://pubmed.ncbi.nlm.nih.gov/25478781"},"language":"en","primary_location":{"id":"doi:10.1021/ac503677d","doi":"https://doi.org/10.1021/ac503677d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac503677d","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020345404","display_name":"Svetla J. Todinova","orcid":"https://orcid.org/0000-0001-7108-051X","observed_orcids":["https://orcid.org/0000-0001-7108-051X"]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Svetla Todinova","raw_affiliation_strings":["Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000720718","display_name":"Sashka Krumova","orcid":"https://orcid.org/0000-0001-7412-8398","observed_orcids":["https://orcid.org/0000-0001-7412-8398"]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Sashka Krumova","raw_affiliation_strings":["Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037177136","display_name":"Ralitsa Radoeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ralitsa Radoeva","raw_affiliation_strings":["Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044120961","display_name":"Lidia Gartcheva","orcid":"https://orcid.org/0000-0002-1889-7640","observed_orcids":["https://orcid.org/0000-0002-1889-7640"]},"institutions":[{"id":"https://openalex.org/I4210124819","display_name":"National Specialized Hospital for Active Treatment of Hematologic Diseases","ror":"https://ror.org/030d7rf51","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210124819"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Lidia Gartcheva","raw_affiliation_strings":["National Specialized Hospital for Active Treating of Haematological Diseases, Sofia 1756, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Specialized Hospital for Active Treating of Haematological Diseases, Sofia 1756, Bulgaria","institution_ids":["https://openalex.org/I4210124819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025919450","display_name":"Stefka Germanova Taneva","orcid":"https://orcid.org/0000-0001-6851-4516","observed_orcids":["https://orcid.org/0000-0001-6851-4516"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG","ES"],"is_corresponding":true,"raw_author_name":"Stefka G. Taneva","raw_affiliation_strings":["Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria","Unidad\rde Biof\u00edsica (CSIC/UPV-EHU) and Departamento de Bioqu\u00edmica\ry Biolog\u00eda Molecular, Universidad del Pa\u00eds Vasco, POB 644, 48080 Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]},{"raw_affiliation_string":"Unidad\rde Biof\u00edsica (CSIC/UPV-EHU) and Departamento de Bioqu\u00edmica\ry Biolog\u00eda Molecular, Universidad del Pa\u00eds Vasco, POB 644, 48080 Bilbao, Spain","institution_ids":["https://openalex.org/I169108374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025919450"],"corresponding_institution_ids":["https://openalex.org/I169108374","https://openalex.org/I24768866","https://openalex.org/I4210103918"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4536,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.82553746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"86","issue":"24","first_page":"12355","last_page":"12361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-secretory-multiple-myeloma","display_name":"non-secretory multiple myeloma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/serum-proteome","display_name":"serum proteome","score":0.8320000171661377},{"id":"https://openalex.org/keywords/differential-scanning-calorimetry","display_name":"differential scanning calorimetry","score":0.8069999814033508},{"id":"https://openalex.org/keywords/free-light-chains","display_name":"free light chains","score":0.7720000147819519},{"id":"https://openalex.org/keywords/monoclonal-protein","display_name":"monoclonal protein","score":0.6850000023841858},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.5559999942779541},{"id":"https://openalex.org/keywords/serum-protein-electrophoresis","display_name":"serum protein electrophoresis","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7317836284637451},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7131989002227783},{"id":"https://openalex.org/C52697466","wikidata":"https://www.wikidata.org/wiki/Q424176","display_name":"Bence Jones protein","level":4,"score":0.6723523139953613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5608716607093811},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.4838046431541443},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.4684842824935913},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42152905464172363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33895909786224365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28073573112487793},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18967214226722717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18722236156463623},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.150046706199646},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12886187434196472}],"mesh":[{"descriptor_ui":"D001536","descriptor_name":"Bence Jones Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac503677d","doi":"https://doi.org/10.1021/ac503677d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac503677d","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:25478781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25478781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323575","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1973267259","https://openalex.org/W1974983065","https://openalex.org/W1976300931","https://openalex.org/W1980432311","https://openalex.org/W1980881602","https://openalex.org/W1981950103","https://openalex.org/W1985409973","https://openalex.org/W1995124410","https://openalex.org/W1995184080","https://openalex.org/W2009945253","https://openalex.org/W2015924126","https://openalex.org/W2020443502","https://openalex.org/W2027333672","https://openalex.org/W2051828923","https://openalex.org/W2055974950","https://openalex.org/W2060048225","https://openalex.org/W2063939741","https://openalex.org/W2064075610","https://openalex.org/W2073689011","https://openalex.org/W2078657965","https://openalex.org/W2085318288","https://openalex.org/W2096022579","https://openalex.org/W2123340007","https://openalex.org/W2123470080","https://openalex.org/W2124240218","https://openalex.org/W2125964109","https://openalex.org/W2129255941","https://openalex.org/W2139842115","https://openalex.org/W2146292669","https://openalex.org/W2155331129","https://openalex.org/W2156838483","https://openalex.org/W2158749981","https://openalex.org/W2323938113","https://openalex.org/W2326721757","https://openalex.org/W2332065208","https://openalex.org/W2979646088"],"related_works":["https://openalex.org/W4291162319","https://openalex.org/W2332065208","https://openalex.org/W2792651631","https://openalex.org/W2532900724","https://openalex.org/W793788349","https://openalex.org/W2564961820","https://openalex.org/W2935562665","https://openalex.org/W4395036394","https://openalex.org/W2481439360","https://openalex.org/W2085318288"],"abstract_inverted_index":{"The":[0,110],"present":[1],"work":[2],"provides":[3],"a":[4],"thermodynamic":[5,41,83],"description":[6],"of":[7,24,43,55,59,78,89,124],"blood":[8],"serum":[9,29,144],"from":[10],"patients":[11],"diagnosed":[12],"with":[13,80,96],"Bence":[14],"Jones":[15],"myeloma":[16,20,100,130],"(BJMM)":[17],"and":[18,32,46,67,75,92,128,183],"nonsecretory":[19],"(NSMM)":[21],"by":[22],"means":[23],"differential":[25],"scanning":[26],"calorimetry":[27],"(DSC),":[28],"protein":[30],"electrophoresis,":[31],"free":[33],"light":[34],"chain":[35],"assay.":[36],"Specific":[37],"alterations":[38],"in":[39,63,164,180],"the":[40,53,56,60,64,68,90,121,125,142,149,161,165,181,184],"behavior":[42],"both":[44],"BJMM":[45,74,91],"NSMM":[47,76,93,158],"proteome":[48],"have":[49],"been":[50],"revealed.":[51],"On":[52],"basis":[54],"transition":[57,62],"temperature":[58],"main":[61],"calorimetric":[65,122,171],"profiles":[66,123,167],"shape":[69],"similarity":[70],"criterion,":[71],"we":[72],"defined":[73,98],"sets/subsets":[77],"thermograms":[79],"very":[81],"similar":[82],"features.":[84],"We":[85,146],"show":[86,134],"that":[87,115,137,148],"some":[88],"subsets":[94,101],"correlate":[95],"previously":[97],"secretory":[99,127],"(Todinova":[102],"et":[103],"al.":[104],"Anal.":[105],"Chem.":[106],"2011,":[107],"83,":[108],"7992).":[109],"established":[111],"analogies":[112],"strongly":[113],"suggest":[114],"common":[116],"molecular":[117],"markers":[118,172],"contribute":[119],"to":[120],"different,":[126],"nonsecretory,":[129],"types;":[131],"our":[132],"data":[133],"robust":[135],"evidence":[136],"these":[138],"are":[139],"ligands":[140],"stabilizing":[141],"major":[143],"proteins.":[145],"demonstrate":[147],"DSC":[150,166],"approach":[151],"might":[152,168],"be":[153,178],"highly":[154],"beneficial,":[155],"especially":[156],"for":[157],"patients,":[159],"since":[160],"characteristic":[162],"modifications":[163],"serve":[169],"as":[170],"when":[173],"no":[174],"monoclonal":[175],"proteins":[176],"can":[177],"detected":[179],"bloodstream":[182],"diagnosis":[185],"heavily":[186],"relies":[187],"on":[188],"invasive":[189],"methods.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}