{"id":"https://openalex.org/W2323032905","doi":"https://doi.org/10.12816/0002438","title":"Effect of Diclofenac on Plasma Glucose Level , Insulin Resistance , Inflammatory Markers and Hepatocytes in Diabetic Albino Rats","display_name":"Effect of Diclofenac on Plasma Glucose Level , Insulin Resistance , Inflammatory Markers and Hepatocytes in Diabetic Albino Rats","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2323032905","doi":"https://doi.org/10.12816/0002438","mag":"2323032905"},"language":"en","primary_location":{"id":"doi:10.12816/0002438","doi":"https://doi.org/10.12816/0002438","is_oa":true,"landing_page_url":"https://doi.org/10.12816/0002438","pdf_url":null,"source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.12816/0002438","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110847996","display_name":"Ashraf M. Mostafa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashraf M. Mostafa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112995304","display_name":"Waleed Samy Mohamed","orcid":"https://orcid.org/0000-0001-9329-5941","observed_orcids":["https://orcid.org/0000-0001-9329-5941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waleed S. Mohamed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029328358","display_name":"Abdel Hamid A. Serwah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdel Hamid A. Serwah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.23726716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":"54","first_page":"117","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.3756999969482422,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.3756999969482422,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.3634999990463257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.8809999823570251},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6489999890327454},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.746999979019165},{"id":"https://openalex.org/keywords/homa-beta","display_name":"HOMA-\u03b2","score":0.7670000195503235},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.5910000205039978},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/glycogen-accumulation","display_name":"glycogen accumulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.8999999761581421},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8740787506103516},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7760055661201477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7715234160423279},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7338294386863708},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5491259098052979},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.5092955827713013},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.4752858877182007},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.47027283906936646},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4440133273601532},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.4218832552433014},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.41804784536361694},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41682168841362},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.3370264768600464},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3130800127983093},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30525079369544983},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.30171334743499756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10999083518981934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06237304210662842},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.12816/0002438","doi":"https://doi.org/10.12816/0002438","is_oa":true,"landing_page_url":"https://doi.org/10.12816/0002438","pdf_url":null,"source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12816/0002438","doi":"https://doi.org/10.12816/0002438","is_oa":true,"landing_page_url":"https://doi.org/10.12816/0002438","pdf_url":null,"source":{"id":"https://openalex.org/S2764396899","display_name":"The Egyptian Journal of Hospital Medicine","issn_l":"1687-2002","issn":["1687-2002","2090-7125"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jpps-2","poland-20"],"host_organization":"https://openalex.org/P4323237894","host_organization_name":"Egypts Presidential Specialized Council for Education and Scientific Research","host_organization_lineage":["https://openalex.org/P4323237894"],"host_organization_lineage_names":["Egypts Presidential Specialized Council for Education and Scientific Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian Journal of Hospital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1503393361","https://openalex.org/W1534360145","https://openalex.org/W1546962148","https://openalex.org/W1801775645","https://openalex.org/W1965260442","https://openalex.org/W2027651381","https://openalex.org/W2031637294","https://openalex.org/W2037566407","https://openalex.org/W2038686627","https://openalex.org/W2067663673","https://openalex.org/W2071073097","https://openalex.org/W2087882379","https://openalex.org/W2098859779","https://openalex.org/W2101328621","https://openalex.org/W2113657976","https://openalex.org/W2117662983","https://openalex.org/W2120456614","https://openalex.org/W2133782112","https://openalex.org/W2143639886","https://openalex.org/W2144144716","https://openalex.org/W2144211575","https://openalex.org/W2160234571","https://openalex.org/W2160297973","https://openalex.org/W2431024571"],"related_works":["https://openalex.org/W1970022001","https://openalex.org/W2365450081","https://openalex.org/W2368110119","https://openalex.org/W2745085879","https://openalex.org/W130231721","https://openalex.org/W3033516131","https://openalex.org/W2558360119","https://openalex.org/W3202306241","https://openalex.org/W2358302227","https://openalex.org/W2807516234"],"abstract_inverted_index":{"Background":[0],"and":[1,27,32,66,79,125,131,143,147,151,174,190,193,205,207,234,266],"aim":[2],"of":[3,197,220,247,263],"the":[4,80,180],"study:":[5],"diabetes":[6,30,257],"wasproposed":[7],"to":[8,17,179],"be":[9],"an":[10,242],"inflam\u00admatory":[11],"disease.\u00a0":[12],"Growing":[13],"evidence":[14],"has":[15],"pointed":[16],"a":[18,185,254],"correlation":[19,187],"between":[20,188],"various":[21],"proinflammatory":[22],"cytokines,":[23],"insulin":[24,169],"resistance":[25],"(IR)":[26],"type":[28],"2":[29],"(T2DM).\r\nMaterials":[31],"Methods:":[33],"This":[34],"study":[35],"was":[36,184],"carried":[37],"out":[38],"on":[39],"one":[40],"hundred":[41],"Albino":[42],"rats,":[43],"distributed":[44],"into":[45],"four":[46],"groups.":[47],"Group":[48,52,59,67],"I:":[49],"control":[50],"group,":[51],"II:":[53],"diabetic":[54,61,69,181,198],"rats":[55,62,70,140,199],"with":[56,64,72,145,171,230],"no":[57],"treatment,":[58],"III:\u00a0":[60],"treated":[63,71,216,222],"Glipenclamid":[65],"IV:":[68],"Diclofenac":[73],"sodium.":[74],"Blood":[75],"samples":[76,137],"were":[77,84,134,141],"taken":[78],"following":[81],"biochemical":[82],"parameters":[83],"done:":[85],"fasting":[86],"blood":[87],"glucose":[88],"(FBG),":[89],"serum":[90,98,102,104,106,109,194],"insulin,":[91],"aspartate":[92],"transaminase":[93,96],"(AST),":[94],"Alanine":[95],"(ALT),":[97],"Alkaline":[99],"Phosphatase":[100],"(ALP),":[101],"protein,":[103],"albumin,":[105],"triglyceride":[107],"(TGs),":[108],"cholesterol":[110],"level":[111],"(TC),":[112],"High":[113],"Density":[114,118],"Lipoprotein":[115,119],"(HDL),":[116],"Low":[117],"(LDL),":[120],"Tumor":[121],"Necrosis":[122],"Factor":[123],"(TNF-\u03b1)":[124],"C-Reactive":[126],"Protein":[127],"(CRP).":[128],"HOMA":[129,132],"IR":[130,173,246,261],"B":[133],"calculated.":[135],"Liver":[136,196],"from":[138],"all":[139],"obtained":[142],"stained":[144],"Hematoxylin":[146],"Eosin,":[148],"Masson's":[149],"trichrome":[150],"Periodic":[152],"acid\u2013Schiff\u00a0(PAS)":[153],"for":[154],"histological":[155],"examination.\r\nResults:":[156],"Declofenac":[157,221],"caused":[158],"significant":[159],"lowering":[160],"in":[161,214,245,256],"FBG,":[162],"lipid":[163],"profile,":[164],"TNF-\u03b1":[165],"level,":[166],"CRP,":[167],"increased":[168],"secretion":[170],"improved":[172,212],"beta":[175],"cell":[176,226],"function":[177],"compared":[178],"group.":[182],"There":[183],"positive":[186],"HOMA-IR":[189,192],"CRP;":[191],"TNF-\u03b1.":[195],"showed":[200],"periportal":[201],"fibrosis,":[202],"vacuolated":[203],"cytoplasm":[204],"nuclei":[206,233],"glycogen":[208,236],"deposition.":[209],"These":[210],"changes":[211],"markedly":[213],"Glibenclamide":[215],"groups":[217],"while":[218],"liver":[219],"group":[223],"revealed":[224],"parenchymal":[225],"necrosis,":[227],"sinusoidal":[228],"dilatation":[229],"some":[231],"pyknotic":[232],"marked":[235],"deposition.\r\nConclusions:":[237],"inflammatory":[238],"pathways":[239],"may":[240,252],"play":[241],"important":[243],"part":[244],"T2DM.":[248],"Therefore,":[249],"antinflammatory":[250],"drugs":[251],"have":[253],"role":[255],"therapy":[258],"through":[259],"improving":[260],"because":[262],"its":[264],"insulin-sensitiz\u00ading":[265],"anti-inflammatory":[267],"properties.":[268]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}