{"id":"https://openalex.org/W2322822467","doi":"https://doi.org/10.1152/ajpheart.00397.2000","title":"Estrogen increases iNOS expression in the ovine coronary artery","display_name":"Estrogen increases iNOS expression in the ovine coronary artery","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2322822467","doi":"https://doi.org/10.1152/ajpheart.00397.2000","mag":"2322822467","pmid":"https://pubmed.ncbi.nlm.nih.gov/12181148"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00397.2000","doi":"https://doi.org/10.1152/ajpheart.00397.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00397.2000","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066217871","display_name":"John L. Mershon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Mershon","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Scott Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Scott Baker","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109417954","display_name":"Kenneth E. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Clark","raw_affiliation_strings":["Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0526","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":3.2376,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91679334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"283","issue":"3","first_page":"H1169","last_page":"H1180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6352999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.972000002861023},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.968999981880188},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.972000002861023},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9670000076293945},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.6539999842643738},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7310000061988831},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.953000009059906},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nuclear-factor-kappab","display_name":"nuclear factor-kappaB","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ewes","display_name":"ewes","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8229045271873474},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7715096473693848},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7170321941375732},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6791718006134033},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6579182147979736},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5512201189994812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47829681634902954},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4716193974018097},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.33918309211730957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3290947675704956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013859","descriptor_name":"Thiocarbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.00397.2000","doi":"https://doi.org/10.1152/ajpheart.00397.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00397.2000","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:12181148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12181148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1031259958","display_name":null,"funder_award_id":"HL-49901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5718522457","display_name":null,"funder_award_id":"HL-62490","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6464248476","display_name":"MOLECULAR MECHANISMS OF ESTROGENS VASCULAR ACTIONS","funder_award_id":"5r01hl062490-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6486431117","display_name":null,"funder_award_id":"HL-51051","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7117893252","display_name":"EDRF REGULATION OF UTERINE AND UMBILICAL BLOOD FLOW","funder_award_id":"5r01hl049901-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G719551156","display_name":"ENDOTHELIUM AND HYPERTENSION AND PREGNANCY","funder_award_id":"5r01hl051051-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1481797092","https://openalex.org/W1490298304","https://openalex.org/W1908877967","https://openalex.org/W1927221034","https://openalex.org/W1964426036","https://openalex.org/W1964957120","https://openalex.org/W1966323574","https://openalex.org/W1973018387","https://openalex.org/W1973626130","https://openalex.org/W1984593535","https://openalex.org/W1985174098","https://openalex.org/W1987149804","https://openalex.org/W1990138433","https://openalex.org/W1990374532","https://openalex.org/W1992335976","https://openalex.org/W1993604851","https://openalex.org/W2000683907","https://openalex.org/W2003640964","https://openalex.org/W2004116525","https://openalex.org/W2015848852","https://openalex.org/W2021324668","https://openalex.org/W2028756696","https://openalex.org/W2036915597","https://openalex.org/W2037768305","https://openalex.org/W2037908635","https://openalex.org/W2040622804","https://openalex.org/W2051034159","https://openalex.org/W2058610272","https://openalex.org/W2058961688","https://openalex.org/W2059070564","https://openalex.org/W2065804122","https://openalex.org/W2070564305","https://openalex.org/W2072742024","https://openalex.org/W2080452316","https://openalex.org/W2082218696","https://openalex.org/W2085558469","https://openalex.org/W2091220555","https://openalex.org/W2092621937","https://openalex.org/W2093195099","https://openalex.org/W2101392591","https://openalex.org/W2108138786","https://openalex.org/W2109581981","https://openalex.org/W2109967955","https://openalex.org/W2113083707","https://openalex.org/W2113264115","https://openalex.org/W2125293265","https://openalex.org/W2128517839","https://openalex.org/W2131483303","https://openalex.org/W2141537184","https://openalex.org/W2147315723","https://openalex.org/W2152136351","https://openalex.org/W2158855816","https://openalex.org/W2159567970","https://openalex.org/W2159780873","https://openalex.org/W2159876289","https://openalex.org/W2161746283","https://openalex.org/W2163982650","https://openalex.org/W2164319707","https://openalex.org/W2181239812","https://openalex.org/W2189495881","https://openalex.org/W2223991930","https://openalex.org/W2275873232","https://openalex.org/W2332056249","https://openalex.org/W2398953807","https://openalex.org/W2615633554","https://openalex.org/W2972867833"],"related_works":["https://openalex.org/W2080452316","https://openalex.org/W2269627311","https://openalex.org/W1988606942","https://openalex.org/W1964426036","https://openalex.org/W2000176464","https://openalex.org/W2003640964","https://openalex.org/W2009718087","https://openalex.org/W2223991930","https://openalex.org/W2008363062","https://openalex.org/W594252244"],"abstract_inverted_index":{"Estrogen":[0],"is":[1,35],"believed":[2],"to":[3],"protect":[4],"postmenopausal":[5],"women":[6],"from":[7],"coronary":[8,45,60,72,83,115,232,252],"vascular":[9,73],"disease,":[10],"in":[11,44,112,190,231,237,255,266,269],"part":[12,160],"by":[13,86,142,172,240],"increasing":[14],"production":[15],"of":[16,30,40,107,126,161,166,175,180,219],"nitric":[17],"oxide":[18],"(NO).":[19],"In":[20],"this":[21,162],"study,":[22],"we":[23],"investigated":[24],"the":[25,41,71,93,105,113,173,178,197,206,247,256],"possibility":[26],"that":[27,249,264],"transcriptional":[28],"activation":[29],"inducible":[31],"NO":[32],"synthase":[33],"(iNOS)":[34],"responsible":[36],"for":[37,77,134,153],"a":[38],"component":[39],"estrogen-induced":[42,229],"increase":[43,268],"blood":[46,84,233,253],"flow.":[47],"Twenty-two":[48],"ewes":[49,65],"were":[50,120,132,147],"instrumented":[51,193],"with":[52],"Doppler":[53],"flow":[54,85,234,254],"probes":[55],"on":[56,109,149],"their":[57],"left":[58],"circumflex":[59],"and":[61,70,92,137,156,235,272],"pulmonary":[62],"arteries.":[63],"Nine":[64],"received":[66,195],"17beta-estradiol":[67,250],"(1":[68],"microg/kg),":[69],"response":[74,95],"was":[75,168,182],"followed":[76],"16":[78],"h.":[79],"Estradiol":[80],"significantly":[81,169],"increased":[82,170],"22":[87],"+/-":[88],"4%":[89],"over":[90,241],"baseline":[91],"peak":[94],"occurred":[96],"at":[97],"2":[98,122],"h":[99,123],"(P":[100],"<":[101],"0.01).":[102],"To":[103,186],"examine":[104],"effect":[106],"estrogen":[108,198],"NOS":[110,139],"expression":[111,141,165,179],"ovine":[114,135,154],"artery,":[116],"17":[117],"noninstrumented":[118],"animals":[119,194],"killed":[121],"after":[124],"administration":[125,174],"estradiol":[127],"or":[128,213],"vehicle.":[129],"Coronary":[130],"arteries":[131],"analyzed":[133],"iNOS":[136,157,167,207,273],"endothelial":[138],"(eNOS)":[140],"semiquantitative":[143],"RT-PCR.":[144],"PCR":[145],"primers":[146],"based":[148],"partial":[150],"cDNA":[151],"clones":[152],"eNOS":[155,181,271],"isolated":[158],"as":[159],"study.":[163],"The":[164],"(27-fold)":[171],"estradiol,":[176],"whereas":[177],"much":[183],"weaker":[184],"(2-fold).":[185],"confirm":[187],"these":[188],"effects":[189],"vivo,":[191],"additional":[192],"either":[196],"receptor":[199],"(ER)":[200],"antagonist":[201,208],"ICI-182,780":[202],"(n":[203,210,222],"=":[204,211,223],"5),":[205,212],"dexamethasone":[209],"pyrrolidine":[214],"dithiocarbamic":[215],"acid,":[216],"an":[217,261,267],"inhibitor":[218],"nuclear":[220],"factor-kappaB":[221],"5).":[224],"All":[225],"three":[226],"antagonists":[227],"inhibited":[228],"increases":[230,236,251],"cardiac":[238],"output":[239],"85%.":[242],"These":[243],"results":[244,265],"strongly":[245],"support":[246],"hypothesis":[248],"unanesthetized":[257],"nonpregnant":[258],"ewe":[259],"via":[260],"ER-dependent":[262],"mechanism":[263],"both":[270],"expression.":[274]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
