{"id":"https://openalex.org/W2322746471","doi":"https://doi.org/10.1158/1538-7445.am10-2206","title":"Abstract 2206: Distinct somatic mutation patterns in multiple human cancers and their subtypes","display_name":"Abstract 2206: Distinct somatic mutation patterns in multiple human cancers and their subtypes","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2322746471","doi":"https://doi.org/10.1158/1538-7445.am10-2206","mag":"2322746471"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-2206","doi":"https://doi.org/10.1158/1538-7445.am10-2206","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2206","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077727557","display_name":"Zhengyan Kan","orcid":"https://orcid.org/0000-0003-4280-0850","observed_orcids":["https://orcid.org/0000-0003-4280-0850"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengyan Kan","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112051548","display_name":"Jeremy Stinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Stinson","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050995572","display_name":"Deeplai Bhatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deeplai Bhatt","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064467439","display_name":"Joshua S. Kaminker","orcid":"https://orcid.org/0000-0001-5067-9275","observed_orcids":["https://orcid.org/0000-0001-5067-9275"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Kaminker","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028575353","display_name":"Howard Marvin Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Stern","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111574602","display_name":"Malek Faham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malek Faham","raw_affiliation_strings":["2MCL DX, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MCL DX, San Francisco, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088898639","display_name":"Somasekar Seshagiri","orcid":"https://orcid.org/0000-0003-4272-6443","observed_orcids":["https://orcid.org/0000-0003-4272-6443"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somasekar Seshagiri","raw_affiliation_strings":["1Genentech Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genentech Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"2206","last_page":"2206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.5889999866485596},{"id":"https://openalex.org/keywords/mutational-patterns","display_name":"mutation patterns","score":0.39399999380111694},{"id":"https://openalex.org/keywords/significantly-mutated-genes","display_name":"significantly mutated genes","score":0.5659999847412109},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/biological-pathways","display_name":"biological pathways","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.7518800497055054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7356277108192444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6584657430648804},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6444556713104248},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6279953122138977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6174182295799255},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.515668511390686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39508336782455444}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-2206","doi":"https://doi.org/10.1158/1538-7445.am10-2206","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2206","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974740818","https://openalex.org/W4287959313","https://openalex.org/W3120062619","https://openalex.org/W1969626557","https://openalex.org/W2265227069","https://openalex.org/W2022495797","https://openalex.org/W2747008976","https://openalex.org/W2018098615","https://openalex.org/W2065713001","https://openalex.org/W2023568503"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"have":[2,107,143,167,191],"systematic":[3],"analyzed":[4,79,93],"4.5Mb":[5],"of":[6,121,132,171,198,214,219],"DNA":[7],"representing":[8],"1507":[9],"genes":[10,88,92,110,123,148],"in":[11,62,68,84,97,153],"450":[12],"human":[13,20],"fresh":[14],"frozen":[15],"tumors":[16],"covering":[17],"four":[18],"major":[19],"cancers":[21,117,154],"and":[22,57,66,103,127,173,182,187,201],"their":[23],"subtypes":[24,128],"for":[25,39,223],"somatic":[26,51,82],"mutations.":[27],"For":[28],"this":[29],"analysis":[30,120,170,194],"we":[31,94,106,142,166,190],"used":[32],"E.":[33],"coli":[34],"mismatch":[35],"repair":[36],"detection":[37],"(MRD)":[38],"our":[40],"primary":[41],"mutation":[42,96,172],"scans.":[43],"All":[44],"the":[45,63,69,75,91,137,156,164,179,196,215,220],"identified":[46,95,108,144,183,202],"variations":[47,176],"were":[48],"validated":[49],"as":[50],"using":[52],"nucleic":[53],"acid":[54],"mass":[55],"spec":[56],"confirmed":[58],"to":[59,111],"be":[60,112],"present":[61],"original":[64],"tumor":[65,77,125,185],"absent":[67],"matched":[70],"adjacent":[71],"normal":[72],"DNA.":[73],"Of":[74,90],"all":[76,116],"samples":[78,180],"\u223c80%":[80],"show":[81],"mutations":[83],"one":[85],"or":[86],"more":[87],"studies.":[89],"842":[98],"genes.":[99,135],"Applying":[100],"statistical":[101],"techniques":[102],"other":[104],"measures":[105],"221":[109],"significantly":[113,133],"mutated":[114,122,134,140,147,204],"across":[115,155],"studied.":[118,160],"Further":[119],"by":[124],"types":[126,159],"revealed":[129],"distinct":[130],"patterns":[131],"Besides":[136],"previously":[138,150],"known":[139],"genes,":[141],"several":[145,203],"novel":[146],"with":[149],"unknown":[151],"role":[152],"various":[157],"cancer":[158],"To":[161],"further":[162],"ascertain":[163],"relevance":[165],"performed":[168,192],"integrated":[169],"copy":[174],"number":[175],"data":[177],"from":[178],"studied":[181],"putative":[184],"supressors":[186],"oncogenes.":[188],"Also,":[189],"mutational":[193],"at":[195],"level":[197],"biological":[199],"pathways":[200],"pathways.":[205],"Citation":[206],"Format:":[207],"{Authors}.":[208],"{Abstract":[209],"title}":[210],"[abstract].":[211],"In:":[212],"Proceedings":[213],"101st":[216],"Annual":[217],"Meeting":[218],"American":[221],"Association":[222],"Cancer":[224,234],"Research;":[225],"2010":[226],"Apr":[227],"17-21;":[228],"Washington,":[229],"DC.":[230],"Philadelphia":[231],"(PA):":[232],"AACR;":[233],"Res":[235],"2010;70(8":[236],"Suppl):Abstract":[237],"nr":[238],"2206.":[239]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
