{"id":"https://openalex.org/W2322563683","doi":"https://doi.org/10.1128/aac.03049-15","title":"Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters","display_name":"Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters","publication_year":2016,"publication_date":"2016-03-29","ids":{"openalex":"https://openalex.org/W2322563683","doi":"https://doi.org/10.1128/aac.03049-15","mag":"2322563683","pmid":"https://pubmed.ncbi.nlm.nih.gov/27021329","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4879383"},"language":"en","primary_location":{"id":"doi:10.1128/aac.03049-15","doi":"https://doi.org/10.1128/aac.03049-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.03049-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4879383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103958512","display_name":"Hiroyuki Sasabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Sasabe","raw_affiliation_strings":["Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113731784","display_name":"Yoshihiko Shimokawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiko Shimokawa","raw_affiliation_strings":["Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019840245","display_name":"Masakazu SHIBATA","orcid":"https://orcid.org/0000-0002-9966-3319","observed_orcids":["https://orcid.org/0000-0002-9966-3319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masakazu Shibata","raw_affiliation_strings":["Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110527252","display_name":"Kenta Hashizume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119711","display_name":"Sekisui Medical (Japan)","ror":"https://ror.org/02deetg88","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210119711","https://openalex.org/I4210164926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Hashizume","raw_affiliation_strings":["ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210119711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021809105","display_name":"Yusuke Hamasako","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119711","display_name":"Sekisui Medical (Japan)","ror":"https://ror.org/02deetg88","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210119711","https://openalex.org/I4210164926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Hamasako","raw_affiliation_strings":["ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210119711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065334424","display_name":"Yoshihiro Ohzone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119711","display_name":"Sekisui Medical (Japan)","ror":"https://ror.org/02deetg88","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210119711","https://openalex.org/I4210164926"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ohzone","raw_affiliation_strings":["ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ADME & Toxicology Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan","institution_ids":["https://openalex.org/I4210119711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082138706","display_name":"Eiji Kashiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eiji Kashiyama","raw_affiliation_strings":["Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021278273","display_name":"Ken Umehara","orcid":"https://orcid.org/0000-0002-8889-5552","observed_orcids":["https://orcid.org/0000-0002-8889-5552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Umehara","raw_affiliation_strings":["Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0771,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77325046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"60","issue":"6","first_page":"3497","last_page":"3508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delamanid","display_name":"delamanid","score":1.0},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8600000143051147},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.9279999732971191},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.8629999756813049},{"id":"https://openalex.org/keywords/solute-carriers","display_name":"solute carrier transporters","score":0.8180000185966492},{"id":"https://openalex.org/keywords/organic-anion-transporting-polypeptides","display_name":"organic anion transporting polypeptides","score":0.9129999876022339},{"id":"https://openalex.org/keywords/oct1","display_name":"OCT1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bile-salt-export-pump","display_name":"bile salt export pump","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drug-transport-inhibition","display_name":"drug transport inhibition","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C512196","wikidata":"https://www.wikidata.org/wiki/Q4650095","display_name":"Abcg2","level":5,"score":0.8870611190795898},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.771978497505188},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.7678014039993286},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7235464453697205},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6793434619903564},{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.6136146783828735},{"id":"https://openalex.org/C189613389","wikidata":"https://www.wikidata.org/wiki/Q70479817","display_name":"Organic cation transport proteins","level":4,"score":0.5986570715904236},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5255885720252991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5250862836837769},{"id":"https://openalex.org/C2776678969","wikidata":"https://www.wikidata.org/wiki/Q28209167","display_name":"Organic anion-transporting polypeptide","level":4,"score":0.47788751125335693},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.45261672139167786},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.4360673427581787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3539760708808899},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.35245293378829956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.257826566696167},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.15513432025909424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000070590","descriptor_name":"Solute Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000070997","descriptor_name":"ATP Binding Cassette Transporter, Subfamily G, Member 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074020","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009593","descriptor_name":"Nitroimidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009593","descriptor_name":"Nitroimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050811","descriptor_name":"Octamer Transcription Factor-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.03049-15","doi":"https://doi.org/10.1128/aac.03049-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.03049-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4053867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4879383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27021329","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27021329","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4879383","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4879383/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4053867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4879383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1063344538","https://openalex.org/W1590490318","https://openalex.org/W1606649779","https://openalex.org/W1612172060","https://openalex.org/W1715824710","https://openalex.org/W1868407335","https://openalex.org/W1967204625","https://openalex.org/W1969586092","https://openalex.org/W1970561042","https://openalex.org/W1975393073","https://openalex.org/W1996794817","https://openalex.org/W2013351783","https://openalex.org/W2017227893","https://openalex.org/W2031784829","https://openalex.org/W2035391560","https://openalex.org/W2037989279","https://openalex.org/W2048161285","https://openalex.org/W2050540577","https://openalex.org/W2066697493","https://openalex.org/W2079197876","https://openalex.org/W2088399416","https://openalex.org/W2103327802","https://openalex.org/W2106044342","https://openalex.org/W2107145299","https://openalex.org/W2117688701","https://openalex.org/W2118654523","https://openalex.org/W2123002505","https://openalex.org/W2131138924","https://openalex.org/W2138557778","https://openalex.org/W2151589354","https://openalex.org/W2152732346","https://openalex.org/W2157279849","https://openalex.org/W2159352542","https://openalex.org/W2163373330","https://openalex.org/W2163881373","https://openalex.org/W2512454832"],"related_works":["https://openalex.org/W1675359132","https://openalex.org/W2163881373","https://openalex.org/W2049593399","https://openalex.org/W2883254266","https://openalex.org/W6941132738","https://openalex.org/W2478506988","https://openalex.org/W2050543542","https://openalex.org/W2514597511","https://openalex.org/W2066697493","https://openalex.org/W6982559017"],"abstract_inverted_index":{"Delamanid":[0,97,144],"(Deltyba,":[1],"OPC-67683)":[2],"is":[3,64,236],"the":[4,16,44,53,74,77,86,102,180,198,207,221,226],"first":[5],"approved":[6],"drug":[7,38],"in":[8,95,202,212,230],"a":[9,135],"novel":[10],"class":[11],"of":[12,18,30,46,55,79,90,139,209,223,225,255],"nitro-dihydro-imidazooxazoles":[13],"developed":[14],"for":[15,137,245],"treatment":[17,25],"multidrug-resistant":[19],"tuberculosis.":[20],"Patients":[21],"with":[22,26,243],"tuberculosis":[23],"require":[24],"multiple":[27,210],"drugs,":[28],"several":[29],"which":[31,246],"have":[32,239],"known":[33],"drug-drug":[34],"interactions.":[35],"Transporters":[36],"regulate":[37],"absorption,":[39],"distribution,":[40],"and":[41,81,88,111,154,168,172,186,192,216,248],"excretion;":[42],"therefore,":[43],"inhibition":[45],"transport":[47,71,174],"by":[48,101,252],"one":[49],"agent":[50],"may":[51],"alter":[52],"pharmacokinetics":[54],"another,":[56],"leading":[57],"to":[58,66,238],"unexpected":[59],"adverse":[60],"events.":[61],"Therefore,":[62],"it":[63],"important":[65],"understand":[67],"how":[68],"delamanid":[69,80,235],"affects":[70],"activity.":[72],"In":[73],"present":[75],"study,":[76],"potencies":[78],"its":[82],"main":[83],"metabolites":[84],"as":[85],"substrates":[87],"inhibitors":[89],"various":[91],"transporters":[92,107,141,151,227],"were":[93],"evaluated":[94],"vitro":[96,231],"was":[98,133],"not":[99,134,219],"transported":[100],"efflux":[103],"ATP-binding":[104],"cassette":[105],"(ABC)":[106],"P-glycoprotein":[108],"(P-gp;":[109],"MDR1/ABCB1)":[110],"breast":[112],"cancer":[113],"resistance":[114],"protein":[115],"(BCRP/ABCG2),":[116],"solute":[117],"carrier":[118],"(SLC)":[119],"transporters,":[120,162],"organic":[121,125,164],"anion-transporting":[122],"polypeptides,":[123],"or":[124,163],"cation":[126],"transporter":[127],"1.":[128],"Similarly,":[129],"metabolite":[130],"1":[131],"(M1)":[132],"substrate":[136],"any":[138,224],"these":[140],"except":[142],"P-gp.":[143],"showed":[145],"no":[146],"inhibitory":[147,182],"effect":[148],"on":[149],"ABC":[150],"MDR1,":[152],"BCRP,":[153],"bile":[155],"salt":[156],"export":[157],"pump":[158],"(BSEP;":[159],"ABCB11),":[160],"SLC":[161],"anion":[165],"transporters.":[166,256],"M1":[167],"M2":[169],"inhibited":[170],"P-gp-":[171],"BCRP-mediated":[173],"but":[175],"did":[176,218],"so":[177],"only":[178],"at":[179],"50%":[181],"concentrations":[183],"(M1,":[184],"4.65":[185],"5.71":[187],"\u03bcmol/liter,":[188,194],"respectively;":[189],"M2,":[190],"7.80":[191],"6.02":[193],"respectively),":[195],"well":[196],"above":[197],"corresponding":[199],"maximum":[200],"concentration":[201],"plasma":[203],"values":[204],"observed":[205],"following":[206],"administration":[208],"doses":[211],"clinical":[213],"trials.":[214],"M3":[215],"M4":[217],"affect":[220],"activities":[222],"tested.":[228],"These":[229],"data":[232],"suggest":[233],"that":[234],"unlikely":[237],"clinically":[240],"relevant":[241],"interactions":[242],"drugs":[244],"absorption":[247],"disposition":[249],"are":[250],"mediated":[251],"this":[253],"group":[254]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
