{"id":"https://openalex.org/W2322484035","doi":"https://doi.org/10.1097/md.0000000000000809","title":"An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population","display_name":"An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population","publication_year":2015,"publication_date":"2015-05-01","ids":{"openalex":"https://openalex.org/W2322484035","doi":"https://doi.org/10.1097/md.0000000000000809","mag":"2322484035","pmid":"https://pubmed.ncbi.nlm.nih.gov/25929937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4603066"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000000809","doi":"https://doi.org/10.1097/md.0000000000000809","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000809","pdf_url":"https://pdfs.journals.lww.com/md-journal/2015/05010/An_Increased_Risk_of_Reversible_Dementia_May_Occur.45.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1543939512450;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzddFRrD2hcIwdDP9eSnSkfs09r6x/Vcvpz6KqX6I/2GjI=;hash|Art54h2i3EUBlY7F/olYyQ==","source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pdfs.journals.lww.com/md-journal/2015/05010/An_Increased_Risk_of_Reversible_Dementia_May_Occur.45.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1543939512450;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzddFRrD2hcIwdDP9eSnSkfs09r6x/Vcvpz6KqX6I/2GjI=;hash|Art54h2i3EUBlY7F/olYyQ==","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038366543","display_name":"Hsin\u2010I Shih","orcid":"https://orcid.org/0000-0002-1103-8675","observed_orcids":["https://orcid.org/0000-0002-1103-8675"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-I Shih","raw_affiliation_strings":["From the Department of Emergency Medicine, National Cheng Kung University Hospital (H-IS, H-CH); Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (H-IS, C-HC); Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Y-FT); Management Office for Health Data, China Medical University Hospital, Taichung (C-CL); Department of Internal Medicine, Division of Geriatrics and Gerontology, National Cheng Kung University Hospital (C-MC); Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan (C-MC); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK)","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Emergency Medicine, National Cheng Kung University Hospital (H-IS, H-CH); Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (H-IS, C-HC); Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Y-FT); Management Office for Health Data, China Medical University Hospital, Taichung (C-CL); Department of Internal Medicine, Division of Geriatrics and Gerontology, National Cheng Kung University Hospital (C-MC); Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan (C-MC); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK)","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829","https://openalex.org/I4210158999","https://openalex.org/I91807558"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100976641","display_name":"Che-Chen Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Che-Chen Lin","raw_affiliation_strings":["From the Department of Emergency Medicine, National Cheng Kung University Hospital (H-IS, H-CH); Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (H-IS, C-HC); Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Y-FT); Management Office for Health Data, China Medical University Hospital, Taichung (C-CL); Department of Internal Medicine, Division of Geriatrics and Gerontology, National Cheng Kung University Hospital (C-MC); Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan (C-MC); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK)","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Emergency Medicine, National Cheng Kung University Hospital (H-IS, H-CH); Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (H-IS, C-HC); Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Y-FT); Management Office for Health Data, China Medical University Hospital, Taichung (C-CL); Department of Internal Medicine, Division of Geriatrics and Gerontology, National Cheng Kung University Hospital (C-MC); Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan (C-MC); Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University (C-HK); and Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan (C-HK)","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829","https://openalex.org/I4210158999","https://openalex.org/I91807558"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026125711","display_name":"Yi\u2010Fang Tu","orcid":"https://orcid.org/0000-0002-9498-6178","observed_orcids":["https://orcid.org/0000-0002-9498-6178"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Fang Tu","raw_affiliation_strings":["Department of Emergency Medicine , National Cheng Kung University Hospital (H-IS , H-CH ); Department of Emergency Medicine ,","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine , National Cheng Kung University Hospital (H-IS , H-CH ); Department of Emergency Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002806525","display_name":"Chia\u2010Ming Chang","orcid":"https://orcid.org/0000-0001-8468-5251","observed_orcids":["https://orcid.org/0000-0001-8468-5251"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Ming Chang","raw_affiliation_strings":["Department of Emergency Medicine , National Cheng Kung University Hospital (H-IS , H-CH ); Department of Emergency Medicine ,","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine , National Cheng Kung University Hospital (H-IS , H-CH ); Department of Emergency Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000076952","display_name":"Hsiang\u2010Chin Hsu","orcid":"https://orcid.org/0000-0002-4350-6701","observed_orcids":["https://orcid.org/0000-0002-4350-6701"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiang-Chin Hsu","raw_affiliation_strings":["H-IS , C-HC) ; Department of Pediatrics , National Cheng Kung University Hospital , College of Medicine ,","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H-IS , C-HC) ; Department of Pediatrics , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059222853","display_name":"Chih\u2010Hsien Chi","orcid":"https://orcid.org/0000-0002-5076-782X","observed_orcids":["https://orcid.org/0000-0002-5076-782X"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Hsien Chi","raw_affiliation_strings":["H-IS , C-HC) ; Department of Pediatrics , National Cheng Kung University Hospital , College of Medicine ,","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H-IS , C-HC) ; Department of Pediatrics , National Cheng Kung University Hospital , College of Medicine ,","institution_ids":["https://openalex.org/I4210158999"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005660358","display_name":"Chia\u2010Hung Kao","orcid":"https://orcid.org/0000-0002-6368-3676","observed_orcids":["https://orcid.org/0000-0002-6368-3676"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Hung Kao","raw_affiliation_strings":["Graduate Institute of Clinical Medical Science and","School of Medicine , College of Medicine , China Medical University , No. 2 , Yuh-Der Road , Taichung 404 , Taiwan","(C-CL)","(C-HK)","(C-MC)","(Y-FT)","C-HC)","H-CH)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Clinical Medical Science and","institution_ids":[]},{"raw_affiliation_string":"School of Medicine , College of Medicine , China Medical University , No. 2 , Yuh-Der Road , Taichung 404 , Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"(C-CL)","institution_ids":[]},{"raw_affiliation_string":"(C-HK)","institution_ids":[]},{"raw_affiliation_string":"(C-MC)","institution_ids":[]},{"raw_affiliation_string":"(Y-FT)","institution_ids":[]},{"raw_affiliation_string":"C-HC)","institution_ids":[]},{"raw_affiliation_string":"H-CH)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005660358"],"corresponding_institution_ids":["https://openalex.org/I184693016"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":4.0627,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94101274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"94","issue":"17","first_page":"e809","last_page":"e809"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.843999981880188},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8220000267028809},{"id":"https://openalex.org/keywords/reversible-dementia","display_name":"reversible dementia","score":0.7210000157356262},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.5609999895095825},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8009999990463257},{"id":"https://openalex.org/keywords/benzodiazepine-like-drugs","display_name":"benzodiazepine-like drugs","score":0.703000009059906},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5460000038146973},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9738729000091553},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7559603452682495},{"id":"https://openalex.org/C2777123777","wikidata":"https://www.wikidata.org/wiki/Q218842","display_name":"Zolpidem","level":3,"score":0.7268014550209045},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5468589067459106},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4175175428390503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3034358322620392},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2951144576072693},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.16668003797531128},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.055928319692611694},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077334","descriptor_name":"Zolpidem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013624","descriptor_name":"Taiwan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000000809","doi":"https://doi.org/10.1097/md.0000000000000809","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000809","pdf_url":"https://pdfs.journals.lww.com/md-journal/2015/05010/An_Increased_Risk_of_Reversible_Dementia_May_Occur.45.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1543939512450;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzddFRrD2hcIwdDP9eSnSkfs09r6x/Vcvpz6KqX6I/2GjI=;hash|Art54h2i3EUBlY7F/olYyQ==","source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmid:25929937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25929937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4603066","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4603066/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000000809","doi":"https://doi.org/10.1097/md.0000000000000809","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000000809","pdf_url":"https://pdfs.journals.lww.com/md-journal/2015/05010/An_Increased_Risk_of_Reversible_Dementia_May_Occur.45.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1543939512450;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzddFRrD2hcIwdDP9eSnSkfs09r6x/Vcvpz6KqX6I/2GjI=;hash|Art54h2i3EUBlY7F/olYyQ==","source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2133633568","display_name":null,"funder_award_id":"MOST 103-2325-B-039 -006","funder_id":"https://openalex.org/F4320322954","funder_display_name":"National Research Program for Biopharmaceuticals"},{"id":"https://openalex.org/G4466220665","display_name":null,"funder_award_id":"BM 104010092","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G958503266","display_name":null,"funder_award_id":"BM104010092","funder_id":"https://openalex.org/F4320322609","funder_display_name":"China Medical University Hospital"}],"funders":[{"id":"https://openalex.org/F4320309368","display_name":"Taiwan Biobank","ror":"https://ror.org/029jvh055"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322609","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32"},{"id":"https://openalex.org/F4320322954","display_name":"National Research Program for Biopharmaceuticals","ror":null},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2322484035.pdf","grobid_xml":"https://content.openalex.org/works/W2322484035.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W12233365","https://openalex.org/W187579988","https://openalex.org/W1969921442","https://openalex.org/W1972700158","https://openalex.org/W1983620103","https://openalex.org/W1987624864","https://openalex.org/W1998156742","https://openalex.org/W2002761901","https://openalex.org/W2004767222","https://openalex.org/W2014886338","https://openalex.org/W2017415119","https://openalex.org/W2029650881","https://openalex.org/W2033792210","https://openalex.org/W2043311439","https://openalex.org/W2048863586","https://openalex.org/W2048970899","https://openalex.org/W2052750026","https://openalex.org/W2054546547","https://openalex.org/W2058145187","https://openalex.org/W2058537083","https://openalex.org/W2062350167","https://openalex.org/W2087574663","https://openalex.org/W2088721660","https://openalex.org/W2091155562","https://openalex.org/W2095280572","https://openalex.org/W2096388559","https://openalex.org/W2098746167","https://openalex.org/W2101264963","https://openalex.org/W2108963305","https://openalex.org/W2113092554","https://openalex.org/W2123731634","https://openalex.org/W2128443648","https://openalex.org/W2129277526","https://openalex.org/W2159480936","https://openalex.org/W2159913036","https://openalex.org/W2266876558","https://openalex.org/W3014251530","https://openalex.org/W3037947155","https://openalex.org/W4211156109","https://openalex.org/W4243693606","https://openalex.org/W6693396503"],"related_works":["https://openalex.org/W2753752849","https://openalex.org/W7113256109","https://openalex.org/W4414223024","https://openalex.org/W4293259979","https://openalex.org/W3120320867","https://openalex.org/W2099603244","https://openalex.org/W2896218591","https://openalex.org/W3211135807","https://openalex.org/W2151571198","https://openalex.org/W3022176997"],"abstract_inverted_index":{"We":[0],"evaluate":[1],"the":[2,14,75,147,156,194],"effects":[3,143,157,195],"of":[4,41,146,149,158],"zolpidem":[5,60,80,159],"use":[6,61,129,138],"to":[7,55,224],"develop":[8,225],"dementia":[9,29,43,63,82,102,213],"or":[10,87],"Alzheimer":[11,154],"disease":[12,164],"from":[13,50],"Taiwan":[15,51],"National":[16],"Health":[17],"Insurance":[18],"Research":[19],"Database":[20],"(NHIRD).A":[21],"retrospective":[22],"population-based":[23],"nested":[24],"case-control":[25],"study.":[26],"Newly":[27],"diagnosed":[28],"patients":[30,161,171,229],"65":[31],"years":[32],"and":[33,35,44,62,68,81,96,126,179,198,237],"older":[34],"controls":[36],"were":[37,48,64,176,202],"sampled.":[38],"A":[39],"total":[40],"8406":[42],"16,812":[45],"control":[46],"subjects":[47],"enrolled":[49],"NHIRD":[52],"during":[53],"2006":[54],"2010.":[56],"The":[57,72,167],"relationships":[58],"between":[59,74,177],"measured":[65],"using":[66],"odds":[67,70],"adjusted":[69,168],"ratios.":[71],"relationship":[73],"average":[76],"cumulative":[77,173,200],"doses":[78,175],"for":[79,105,144,170,196,212],"was":[83,98,191],"also":[84,139],"analyzed.Zolpidem":[85],"alone":[86],"with":[88,101,153,162,209,230],"other":[89],"underlying":[90,231],"diseases,":[91,155],"such":[92,108,233],"as":[93,109,234],"hypertension,":[94,235],"diabetes,":[95,115,236],"stroke,":[97,118],"significantly":[99],"associated":[100,208],"after":[103],"controlling":[104],"potential":[106],"confounders,":[107],"age,":[110],"sex,":[111],"coronary":[112],"artery":[113],"disease,":[114],"anti-hypertension":[116],"drugs,":[117,121],"anticholesterol":[119],"statin":[120],"depression,":[122],"anxiety,":[123],"benzodiazepine,":[124],"anti-psychotic,":[125],"anti-depressant":[127],"agents'":[128],"(Adjusted":[130],"OR":[131,169],"=":[132,189],"1.33,":[133],"95%":[134,185],"CI":[135,186],"1.24-1.41).":[136],"Zolpidem":[137],"has":[140],"significant":[141],"dose-response":[142],"most":[145],"types":[148],"dementia.":[150],"In":[151],"patient":[152],"among":[160],"Alzheimer's":[163],"remained":[165],"obscure.":[166],"whose":[172],"exposure":[174],"170":[178],"819":[180],"mg/year":[181],"(adjusted":[182],"OR:":[183],"1.65,":[184],"1.08-2.51,":[187],"P":[188],"0.0199)":[190],"significant;":[192],"however,":[193],"lower":[197],"higher":[199,222],"dose":[201,219],"not":[203],"significant.Zolpidem":[204],"used":[205],"might":[206,220],"be":[207],"increased":[210],"risk":[211,223],"in":[214,228],"elderly":[215],"population.":[216],"Increased":[217],"accumulative":[218],"have":[221],"dementia,":[226],"especially":[227],"diseases":[232],"stroke.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}