{"id":"https://openalex.org/W2322451369","doi":"https://doi.org/10.1097/00043426-199809000-00018","title":"Multicentric Osteosarcoma, Rothmund-Thomson Syndrome, and Secondary Nasopharyngeal Non-Hodgkin\u02bcs Lymphoma","display_name":"Multicentric Osteosarcoma, Rothmund-Thomson Syndrome, and Secondary Nasopharyngeal Non-Hodgkin\u02bcs Lymphoma","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2322451369","doi":"https://doi.org/10.1097/00043426-199809000-00018","mag":"2322451369","pmid":"https://pubmed.ncbi.nlm.nih.gov/9787328"},"language":"en","primary_location":{"id":"doi:10.1097/00043426-199809000-00018","doi":"https://doi.org/10.1097/00043426-199809000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-199809000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001676353","display_name":"Christopher F. Spurney","orcid":"https://orcid.org/0000-0003-2493-5735","observed_orcids":["https://orcid.org/0000-0003-2493-5735"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Spurney","raw_affiliation_strings":["New York Medical College, Valhalla, USA","New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College, Valhalla, USA","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I181190671","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032743242","display_name":"Richard Greg Gorlick","orcid":"https://orcid.org/0000-0001-8995-2929","observed_orcids":["https://orcid.org/0000-0001-8995-2929"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Gorlick","raw_affiliation_strings":["New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I181190671","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010913859","display_name":"Paul A. Meyers","orcid":"https://orcid.org/0000-0001-6146-6101","observed_orcids":["https://orcid.org/0000-0001-6146-6101"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Meyers","raw_affiliation_strings":["New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I181190671","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022207361","display_name":"John H. Healey","orcid":"https://orcid.org/0000-0002-0802-1186","observed_orcids":["https://orcid.org/0000-0002-0802-1186"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Healey","raw_affiliation_strings":["New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I181190671","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017081282","display_name":"Andrew G. Huvos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew G. Huvos","raw_affiliation_strings":["New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Medical College (C.S.). Valhalla. New York, and the Departments of Pediatrics (R.G., P.A.M.), Orthopaedic Surgery (J.H.), and Pathology (A.G.H.). Memorial Sloan-Kettering Cancer Center and Cornell University Medical College. New York, New York. U.S.A","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I181190671","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7349,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8457857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"5","first_page":"494","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.07819999754428864,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rothmund-thomson-syndrome","display_name":"Rothmund-Thomson syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chemotherapy-induced-malignancy","display_name":"chemotherapy-induced malignancy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8119999766349792},{"id":"https://openalex.org/keywords/poikiloderma","display_name":"poikiloderma","score":0.7559999823570251},{"id":"https://openalex.org/keywords/autosomal-recessive-disorder","display_name":"autosomal recessive disorder","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9610909223556519},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.5684431791305542},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5532724261283875},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.4997518062591553},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4766203463077545},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31176114082336426}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009303","descriptor_name":"Nasopharyngeal Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011038","descriptor_name":"Rothmund-Thomson Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018951","descriptor_name":"Antigens, CD20","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00043426-199809000-00018","doi":"https://doi.org/10.1097/00043426-199809000-00018","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00043426-199809000-00018","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:9787328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9787328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W150216609","https://openalex.org/W206701898","https://openalex.org/W1867534363","https://openalex.org/W1946181835","https://openalex.org/W1973880372","https://openalex.org/W1987073614","https://openalex.org/W2001990804","https://openalex.org/W2005542290","https://openalex.org/W2013556593","https://openalex.org/W2016705920","https://openalex.org/W2022645679","https://openalex.org/W2024059160","https://openalex.org/W2040956419","https://openalex.org/W2058778378","https://openalex.org/W2061153865","https://openalex.org/W2064942973","https://openalex.org/W2072972796","https://openalex.org/W2076136092","https://openalex.org/W2078122319","https://openalex.org/W2079458890","https://openalex.org/W2084800126","https://openalex.org/W2085524820","https://openalex.org/W2091857448","https://openalex.org/W2125447580","https://openalex.org/W2131768915","https://openalex.org/W2133029404","https://openalex.org/W2182659781","https://openalex.org/W2397308231","https://openalex.org/W2471904261","https://openalex.org/W4245103890"],"related_works":["https://openalex.org/W2079458890","https://openalex.org/W2110781456","https://openalex.org/W3048019199","https://openalex.org/W2078122319","https://openalex.org/W2084800126","https://openalex.org/W2126201110","https://openalex.org/W2025203151","https://openalex.org/W2076136092","https://openalex.org/W2048530467","https://openalex.org/W2992164084"],"abstract_inverted_index":{"PURPOSE:":[0],"Rothmund-Thomson":[1],"syndrome":[2],"(RTS)":[3],"is":[4,19,50,77,83],"an":[5,23],"autosomal":[6],"recessive":[7],"disease":[8],"characterized":[9],"by":[10],"poikiloderma,":[11],"photosensitivity,":[12],"skeletal":[13],"deformities,":[14],"and":[15,35,54,76,109],"other":[16],"changes.":[17],"It":[18],"also":[20],"associated":[21],"with":[22,43,63,72,90],"increased":[24],"risk":[25],"of":[26,33,87],"malignancies,":[27],"including":[28],"osteosarcoma.":[29],"Sixteen":[30],"previous":[31,110],"cases":[32],"RTS":[34,44,91],"osteosarcoma":[36,48,94],"have":[37],"been":[38],"reported.":[39],"PATIENT:":[40],"A":[41],"patient":[42,69,89],"in":[45,78,95,103],"whom":[46,96],"multicentric":[47],"developed":[49,61],"described.":[51],"After":[52],"surgery":[53],"chemotherapy,":[55],"a":[56,88,97],"secondary":[57],"malignant":[58],"neoplasm":[59],"(SMN)":[60],"consistent":[62],"nasopharyngeal":[64],"non-Hodgkin's":[65],"lymphoma.":[66],"RESULTS:":[67],"The":[68],"was":[70],"treated":[71,92],"anti-CD20":[73],"monoclonal":[74],"antibody":[75],"complete":[79],"remission.":[80],"CONCLUSION:":[81],"This":[82],"the":[84],"first":[85],"report":[86],"for":[93],"SMN":[98,105],"developed.":[99],"Potential":[100],"factors":[101],"involved":[102],"this":[104],"include":[106],"genetic":[107],"predisposition":[108],"chemotherapy.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}