{"id":"https://openalex.org/W2322318355","doi":"https://doi.org/10.1097/00004836-199712000-00026","title":"Hyperammonemic Encephalopathy After Chemotherapy","display_name":"Hyperammonemic Encephalopathy After Chemotherapy","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2322318355","doi":"https://doi.org/10.1097/00004836-199712000-00026","mag":"2322318355","pmid":"https://pubmed.ncbi.nlm.nih.gov/9451687"},"language":"en","primary_location":{"id":"doi:10.1097/00004836-199712000-00026","doi":"https://doi.org/10.1097/00004836-199712000-00026","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004836-199712000-00026","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063745644","display_name":"Marian A. F. Del Rosario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marian del Rosario","raw_affiliation_strings":["Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA","Dr. del Rosario's current affiliation is Department of Pediatrics, University of Indiana School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Dr. del Rosario's current affiliation is Department of Pediatrics, University of Indiana School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087885832","display_name":"Steven L. Werlin","orcid":"https://orcid.org/0000-0003-1080-8057","observed_orcids":["https://orcid.org/0000-0003-1080-8057"]},"institutions":[{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven L. Werlin","raw_affiliation_strings":["and reprint requests to Dr. Steven L. Werlin, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226","the Department of Pediatrics, Divisions of Gastroenterology and Hematology, Oncology and Transplant, The Medical College of Wisconsin and The Childrens Hospital of Wisconsin, Milwaukee, Wisconsin","reprint requests to Dr. Steven L. Werlin, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Dr. Steven L. Werlin, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"the Department of Pediatrics, Divisions of Gastroenterology and Hematology, Oncology and Transplant, The Medical College of Wisconsin and The Childrens Hospital of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]},{"raw_affiliation_string":"reprint requests to Dr. Steven L. Werlin, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108810254","display_name":"Stephen J. Lauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126218986","display_name":"Children's Hospital of Wisconsin","ror":"https://ror.org/049cbmb74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126218986"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Lauer","raw_affiliation_strings":["the Department of Pediatrics, Divisions of Gastroenterology and Hematology, Oncology and Transplant, The Medical College of Wisconsin and The Childrens Hospital of Wisconsin, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pediatrics, Divisions of Gastroenterology and Hematology, Oncology and Transplant, The Medical College of Wisconsin and The Childrens Hospital of Wisconsin, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087885832"],"corresponding_institution_ids":["https://openalex.org/I126218986","https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.7976,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.66204346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"4","first_page":"682","last_page":"684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.20640000700950623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.20640000700950623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.14030000567436218,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperammonemia","display_name":"hyperammonemia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/encephalopathy","display_name":"encephalopathy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sodium-benzoate","display_name":"sodium benzoate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sodium-phenylacetate","display_name":"sodium phenylacetate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.918103814125061},{"id":"https://openalex.org/C2781099255","wikidata":"https://www.wikidata.org/wiki/Q1640868","display_name":"Hyperammonemia","level":2,"score":0.9179419279098511},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7232867479324341},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.6738027334213257},{"id":"https://openalex.org/C2777574038","wikidata":"https://www.wikidata.org/wiki/Q423971","display_name":"Sodium benzoate","level":2,"score":0.5422727465629578},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.4356663227081299},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.39327511191368103},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34392789006233215},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3399951756000519},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33079516887664795},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11464899778366089}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000963","descriptor_name":"Antimetabolites","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019817","descriptor_name":"Benzoic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004836-199712000-00026","doi":"https://doi.org/10.1097/00004836-199712000-00026","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004836-199712000-00026","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},{"id":"pmid:9451687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9451687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical gastroenterology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W160617378","https://openalex.org/W1988270377","https://openalex.org/W1996520780","https://openalex.org/W2020494619","https://openalex.org/W2029373248","https://openalex.org/W2044409721","https://openalex.org/W2044694916","https://openalex.org/W2050058745","https://openalex.org/W2068174854","https://openalex.org/W2133143905","https://openalex.org/W2401530191","https://openalex.org/W2415945522"],"related_works":["https://openalex.org/W2470092116","https://openalex.org/W2016788570","https://openalex.org/W2069873775","https://openalex.org/W2394976836","https://openalex.org/W3215070109","https://openalex.org/W7202049253","https://openalex.org/W1988270377","https://openalex.org/W4296485198","https://openalex.org/W2312230656","https://openalex.org/W2029373248"],"abstract_inverted_index":{"A":[0],"16-year-old":[1],"boy":[2],"had":[3],"hyperammonemia":[4],"and":[5,25],"encephalopathy":[6],"develop":[7],"after":[8],"high-dose":[9],"chemotherapy":[10],"for":[11],"acute":[12],"lymphoblastic":[13],"leukemia.":[14],"He":[15],"was":[16],"treated":[17],"successfully":[18],"with":[19],"the":[20],"ammonia-trapping":[21],"agents":[22],"sodium":[23,26],"benzoate":[24],"phenylacetate.":[27]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}