{"id":"https://openalex.org/W2322232138","doi":"https://doi.org/10.1080/00450618.2016.1153148","title":"Liquid chromatography tandem mass spectrometric method validation for the quantification of buprenorphine and norbuprenorphine in whole blood","display_name":"Liquid chromatography tandem mass spectrometric method validation for the quantification of buprenorphine and norbuprenorphine in whole blood","publication_year":2016,"publication_date":"2016-03-30","ids":{"openalex":"https://openalex.org/W2322232138","doi":"https://doi.org/10.1080/00450618.2016.1153148","mag":"2322232138"},"language":"en","primary_location":{"id":"doi:10.1080/00450618.2016.1153148","doi":"https://doi.org/10.1080/00450618.2016.1153148","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00450618.2016.1153148","pdf_url":null,"source":{"id":"https://openalex.org/S17551671","display_name":"Australian Journal of Forensic Sciences","issn_l":"0045-0618","issn":["0045-0618","1834-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian Journal of Forensic Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007280277","display_name":"Kar-Weng Chan","orcid":"https://orcid.org/0000-0002-0449-1025","observed_orcids":["https://orcid.org/0000-0002-0449-1025"]},"institutions":[{"id":"https://openalex.org/I134138859","display_name":"Ministry of Science, Technology and Innovation","ror":"https://ror.org/012s3r374","country_code":"MY","type":"government","lineage":["https://openalex.org/I134138859"]},{"id":"https://openalex.org/I4387153777","display_name":"Department of Chemistry Malaysia","ror":"https://ror.org/04g1zbq46","country_code":"MY","type":"government","lineage":["https://openalex.org/I4387153777"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Kar-Weng Chan","raw_affiliation_strings":["Department of Chemistry Malaysia, Ministry of Science Technology and Innovation (MOSTI), Petaling Jaya, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Malaysia, Ministry of Science Technology and Innovation (MOSTI), Petaling Jaya, Malaysia","institution_ids":["https://openalex.org/I134138859","https://openalex.org/I4387153777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055919523","display_name":"Hasni Harun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134138859","display_name":"Ministry of Science, Technology and Innovation","ror":"https://ror.org/012s3r374","country_code":"MY","type":"government","lineage":["https://openalex.org/I134138859"]},{"id":"https://openalex.org/I4387153777","display_name":"Department of Chemistry Malaysia","ror":"https://ror.org/04g1zbq46","country_code":"MY","type":"government","lineage":["https://openalex.org/I4387153777"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Hasni Harun","raw_affiliation_strings":["Department of Chemistry Malaysia, Ministry of Science Technology and Innovation (MOSTI), Petaling Jaya, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Malaysia, Ministry of Science Technology and Innovation (MOSTI), Petaling Jaya, Malaysia","institution_ids":["https://openalex.org/I134138859","https://openalex.org/I4387153777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007280277"],"corresponding_institution_ids":["https://openalex.org/I134138859","https://openalex.org/I4387153777"],"apc_list":null,"apc_paid":null,"fwci":1.6341,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80619748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"49","issue":"2","first_page":"186","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buprenorphine","display_name":"buprenorphine","score":1.0},{"id":"https://openalex.org/keywords/norbuprenorphine","display_name":"norbuprenorphine","score":1.0},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.6510000228881836},{"id":"https://openalex.org/keywords/lc-ms-ms-method-validation","display_name":"LC-MS/MS method validation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/alkaline-extraction","display_name":"alkaline extraction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/c18-solid-phase-extraction","display_name":"C18 solid-phase extraction","score":0.5289999842643738},{"id":"https://openalex.org/keywords/forensic-toxicology","display_name":"forensic toxicology","score":0.7200000286102295},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.5189999938011169},{"id":"https://openalex.org/keywords/limit-of-quantification","display_name":"limit of quantification","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7741064429283142},{"id":"https://openalex.org/C2778949969","wikidata":"https://www.wikidata.org/wiki/Q407721","display_name":"Buprenorphine","level":4,"score":0.6140816807746887},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5099602937698364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46002474427223206},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.43284448981285095},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.34524303674697876},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.051494598388671875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/00450618.2016.1153148","doi":"https://doi.org/10.1080/00450618.2016.1153148","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00450618.2016.1153148","pdf_url":null,"source":{"id":"https://openalex.org/S17551671","display_name":"Australian Journal of Forensic Sciences","issn_l":"0045-0618","issn":["0045-0618","1834-562X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian Journal of Forensic Sciences","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W170231981","https://openalex.org/W194322098","https://openalex.org/W1971783191","https://openalex.org/W1985691056","https://openalex.org/W2010835452","https://openalex.org/W2012965659","https://openalex.org/W2013012793","https://openalex.org/W2027087347","https://openalex.org/W2033463451","https://openalex.org/W2034513172","https://openalex.org/W2034574329","https://openalex.org/W2058234663","https://openalex.org/W2069844822","https://openalex.org/W2076701694","https://openalex.org/W2093431292","https://openalex.org/W2094015709","https://openalex.org/W2107570847","https://openalex.org/W2110436248","https://openalex.org/W2128983897","https://openalex.org/W2142103248","https://openalex.org/W2162010569","https://openalex.org/W3129998784","https://openalex.org/W4233263840"],"related_works":["https://openalex.org/W2107570847","https://openalex.org/W2084571497","https://openalex.org/W2039060143","https://openalex.org/W2027087347","https://openalex.org/W2058222322","https://openalex.org/W2069844822","https://openalex.org/W2218967143","https://openalex.org/W2370569162","https://openalex.org/W2327400357","https://openalex.org/W1987627204"],"abstract_inverted_index":{"A":[0,83],"liquid":[1],"chromatography":[2],"tandem":[3],"mass":[4],"spectrometric":[5],"(LC-MS/MS)":[6],"method":[7,94,171,179],"was":[8,68,89,154],"developed":[9],"for":[10,74,91,99,123,146,162,182],"the":[11,48,52,76,124,139,150,169],"determination":[12],"of":[13,39,54,133],"buprenorphine":[14],"and":[15,36,109,120,143,192],"norbuprenorphine":[16,116],"present":[17],"in":[18,46,79],"whole":[19],"blood":[20],"using":[21],"codeine-d3":[22],"as":[23,186],"an":[24,30,80,104,110],"internal":[25],"standard.":[26],"In":[27],"this":[28,166],"study,":[29],"alkaline":[31],"buffer":[32],"solution":[33],"(pH":[34],"12)":[35],"a":[37,55,58,131],"mixture":[38],"9:1":[40],"ethyl":[41],"acetate:cyclohexane":[42],"were":[43],"found":[44],"efficient":[45],"extracting":[47],"target":[49,77],"compounds.":[50,148],"With":[51],"aid":[53],"C18":[56],"column,":[57],"mobile":[59],"phase":[60],"containing":[61],"45:15:40":[62],"acidic":[63,66],"acetonitrile:":[64],"methanol:":[65],"water":[67],"also":[69],"proved":[70],"to":[71,156,190],"be":[72,157],"sufficient":[73],"resolving":[75],"compounds":[78],"isocratic":[81],"manner.":[82],"positive":[84],"electrospray":[85],"ionisation":[86],"mode":[87],"(ESI+)":[88],"utilised":[90],"detection.":[92],"The":[93,127],"presented":[95],"imprecision":[96],"<":[97],"12%":[98],"both":[100,147],"analytes.":[101],"Buprenorphine":[102],"achieved":[103,172],"MDL":[105],"=":[106,112],"1.2":[107],"ng/mL":[108,119,122,145,161,176],"LOQ":[111],"4.4":[113],"ng/mL,":[114],"whereas":[115],"obtained":[117],"0.9":[118],"3.4":[121],"respective":[125],"measures.":[126],"regression":[128],"lines":[129],"showed":[130],"coefficient":[132],"determination,":[134],"R2":[135],">":[136],"0.99":[137],"over":[138],"range":[140,153],"between":[141],"10":[142,158],"400":[144],"However,":[149],"preferred":[151],"working":[152],"decided":[155],"\u2013":[159],"200":[160],"routine":[163,167],"calibration.":[164],"Within":[165],"range,":[168],"overall":[170],"83.5\u2013103.1%":[173],"accuracy":[174],"at":[175],"level.":[177],"This":[178],"is":[180,188],"suitable":[181],"high":[183],"throughput":[184],"analysis":[185],"it":[187],"easy":[189],"use":[191],"affords":[193],"rapid":[194],"analysis.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}