{"id":"https://openalex.org/W2322016884","doi":"https://doi.org/10.1158/1538-7445.am10-5369","title":"Abstract 5369: AN019 in combination with ionizing radiation retards intracranial tumor growth and inhibits angiogenic induction in vitro and in vivo","display_name":"Abstract 5369: AN019 in combination with ionizing radiation retards intracranial tumor growth and inhibits angiogenic induction in vitro and in vivo","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2322016884","doi":"https://doi.org/10.1158/1538-7445.am10-5369","mag":"2322016884"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-5369","doi":"https://doi.org/10.1158/1538-7445.am10-5369","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-5369","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110995347","display_name":"Christopher S. Gondi","orcid":"https://orcid.org/0000-0002-3036-9920","observed_orcids":["https://orcid.org/0000-0002-3036-9920"]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Gondi","raw_affiliation_strings":["1Univ. of Illinois College of Medicine, Peoria, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Illinois College of Medicine, Peoria, IL","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010176744","display_name":"Bharathi Gorantla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharathi Gorantla","raw_affiliation_strings":["1Univ. of Illinois College of Medicine, Peoria, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Illinois College of Medicine, Peoria, IL","institution_ids":["https://openalex.org/I4210130227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058780447","display_name":"A.K.S. Bhujanga Rao","orcid":"https://orcid.org/0009-0000-9966-2853","observed_orcids":["https://orcid.org/0009-0000-9966-2853"]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A.K.S. Bhujanga Rao","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064438895","display_name":"K.G. Amala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Amala","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104043275","display_name":"M.U.R. Naidu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M.U.R. Naidu","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074185330","display_name":"K.V. Jogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K.V. Jogi","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109602076","display_name":"Gogula Venkat Ramana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G.V. Ramana","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059263576","display_name":"M. Praveen Chowdary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149203","display_name":"Natco Pharma (India)","ror":"https://ror.org/05xth1n37","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149203"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. Praveen Chowdary","raw_affiliation_strings":["2NATCO Research Center, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NATCO Research Center, Hyderabad, India","institution_ids":["https://openalex.org/I4210149203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103756554","display_name":"Jasti Sambasiva Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130227","display_name":"Peoria campus of the University of Illinois System","ror":"https://ror.org/02qrdc062","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210130227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasti S. Rao","raw_affiliation_strings":["1Univ. of Illinois College of Medicine, Peoria, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Univ. of Illinois College of Medicine, Peoria, IL","institution_ids":["https://openalex.org/I4210130227"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"5369","last_page":"5369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.4350999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.8550000190734863},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/egfrviii","display_name":"EGFRvIII","score":0.7620000243186951},{"id":"https://openalex.org/keywords/glioma-invasion","display_name":"glioma invasion","score":0.6399999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/alkylating-agent-resistance","display_name":"alkylating agent resistance","score":0.7129999995231628},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6159999966621399},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9217290878295898},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7254273891448975},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6330826878547668},{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.588995099067688},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5580019354820251},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5363152623176575},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5335075855255127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5254123210906982},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.5069661140441895},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.47209566831588745},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3155508041381836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31141334772109985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18262386322021484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07527816295623779},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-5369","doi":"https://doi.org/10.1158/1538-7445.am10-5369","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-5369","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7599999904632568,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739763830","https://openalex.org/W2024930137","https://openalex.org/W2037408509","https://openalex.org/W2918400576","https://openalex.org/W1547055572","https://openalex.org/W2026514919","https://openalex.org/W2146107023","https://openalex.org/W7099764221","https://openalex.org/W7095316485","https://openalex.org/W2748793175"],"abstract_inverted_index":{"Abstract":[0],"Successful":[1],"treatment":[2,27,171,243],"of":[3,11,22,36,42,46,52,70,132,159,183,199,215,222,239,253,272,282,288,299,331,336],"malignant":[4],"glioma":[5,91,97,137],"is":[6,48],"hampered":[7],"by":[8],"the":[9,43,49,60,68,129,205,213,283,332,337],"development":[10,69],"resistance":[12],"to":[13,24,38,59,174,187,203,248],"alkylating":[14],"agents":[15],"such":[16],"as":[17],"Temozolomide":[18,47,115],"(TMZ).":[19],"The":[20],"addition":[21],"radiation":[23,147],"a":[25,71,90,245,302],"TMZ":[26,140,200,242,292],"regime":[28],"has":[29,312],"shown":[30],"promising":[31],"results":[32,308],"with":[33,80,227,232,259,264,301],"reported":[34],"survivability":[35],"up":[37],"5":[39],"years.":[40],"One":[41],"side":[44],"effects":[45],"increased":[50],"activation":[51],"angiogenic":[53,150,160],"factors":[54],"which":[55,143,318],"may":[56,319],"work":[57],"contrary":[58],"desired":[61],"result.":[62],"In":[63],"this":[64,102],"report":[65],"we":[66],"demonstrate":[67,309],"novel":[72],"compound":[73],"AN019,":[74],"showing":[75],"specific":[76],"VEGF":[77,216,240,254],"suppression":[78],"accompanied":[79],"anti-angiogenic":[81],"and":[82,94,135,151,162,166,194,210,225,230,257,262,280,315],"anti-proliferative":[83,112,314],"properties":[84,317],"in":[85,164,191,277],"gliomas.":[86],"We":[87],"used":[88],"U87,":[89],"cell":[92],"line,":[93],"EGFRvIII":[95],"over-expressing":[96],"xenograft":[98],"4910":[99,136,167,195],"cells":[100,138,142,168],"for":[101,212,236,340],"study.":[103],"Deduced":[104],"IC50":[105],"values":[106],"indicated":[107,125,218],"that":[108,126,180,219,269,310],"AN019":[109,127,170,184,223,273,311],"had":[110],"greater":[111],"effect":[113],"than":[114],"(U87:":[116],"AN019=103\u00b5M,":[117],"TMZ=768\u00b5M;":[118],"4910:":[119],"AN019=169\u00b5M,":[120],"TMZ=582\u00b5M).":[121],"Matrigel":[122],"invasion":[123],"assay":[124],"retarded":[128],"invasive":[130],"potential":[131],"both":[133,192],"U87":[134,165,193],"over":[139],"treated":[141,294],"was":[144,185,201],"enhanced":[145],"after":[146,169],"treatment.":[148],"In-vitro":[149],"migration":[152,163],"assays":[153],"showed":[154,268,285,297],"an":[155],"almost":[156],"complete":[157,286],"inhibition":[158,238,252],"induction":[161],"when":[172],"compared":[173],"TMZ.":[175],"Cell":[176],"cycle":[177],"analysis":[178],"revealed":[179],"100\u00b5g/ml":[181],"concentration":[182,247],"sufficient":[186],"achieve":[188,204,249],">70%":[189],"apoptosis":[190],"cells,":[196],"whereas":[197,291],"150\u00b5g/ml":[198],"required":[202,235,244],"same":[206],"response.":[207],"Western":[208],"blot":[209],"ELISA":[211],"expression":[214,255],"levels":[217],"lower":[220],"concentrations":[221],"(U87=86\u00b13\u00b5g/ml":[224],"12\u00b11\u00b5g/ml":[226],"radiation;":[228,260],"4910=100\u00b11\u00b5g/ml":[229],"6\u00b5g/ml":[231],"radiation)":[233],"were":[234],"50%":[237,251],"expression.":[241],"higher":[246],"similar":[250],"(U87=80\u00b110\u00b5g/ml":[256],"12\u00b13\u00b5g/ml":[258],"4910=100\u00b13\u00b5g/ml":[261],"27\u00b13\u00b5g/ml":[263],"radiation).":[265],"Animal":[266],"studies":[267],"oral":[270],"doses":[271],"(20mg/kg)":[274],"regressed":[275],"tumors":[276,300],"all":[278],"animals":[279,284,295],"70%":[281],"absence":[287],"intracranial":[289],"tumors,":[290],"(100mg/kg)":[293],"also":[296],"regression":[298],"30%":[303],"cure":[304],"rate.":[305],"Overall,":[306],"our":[307],"anti-angiogenic,":[313],"anti-tumorogenic":[316],"have":[320],"clinical":[321],"implications.":[322],"Citation":[323],"Format:":[324],"{Authors}.":[325],"{Abstract":[326],"title}":[327],"[abstract].":[328],"In:":[329],"Proceedings":[330],"101st":[333],"Annual":[334],"Meeting":[335],"American":[338],"Association":[339],"Cancer":[341,351],"Research;":[342],"2010":[343],"Apr":[344],"17-21;":[345],"Washington,":[346],"DC.":[347],"Philadelphia":[348],"(PA):":[349],"AACR;":[350],"Res":[352],"2010;70(8":[353],"Suppl):Abstract":[354],"nr":[355],"5369.":[356]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}