{"id":"https://openalex.org/W2322016291","doi":"https://doi.org/10.2307/3576053","title":"Thermotolerance in Cultured Hepatoma Cells: Cell Viability, Cell Morphology, Protein Synthesis, and Heat-Shock Proteins","display_name":"Thermotolerance in Cultured Hepatoma Cells: Cell Viability, Cell Morphology, Protein Synthesis, and Heat-Shock Proteins","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W2322016291","doi":"https://doi.org/10.2307/3576053","mag":"2322016291","pmid":"https://pubmed.ncbi.nlm.nih.gov/6718697"},"language":"en","primary_location":{"id":"doi:10.2307/3576053","doi":"https://doi.org/10.2307/3576053","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3576053","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111732807","display_name":"D. H. J. Schamhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis H. J. Schamhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070779124","display_name":"Hendrika S. VAN WALRAVEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hendrika S. van Walraven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113487487","display_name":"F. A. C. Wiegant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederik A. C. Wiegant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073010010","display_name":"Wilbert A. M. Linnemans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilbert A. M. Linnemans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040476253","display_name":"Johannes Van Rijn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes van Rijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jaap van den Berg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaap van den Berg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112292842","display_name":"Roeland Van Wijk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roeland van Wijk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0403,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.87886162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"98","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermal-tolerance","display_name":"heat tolerance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hepatoma-cells","display_name":"hepatoma cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.890999972820282},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cell-rounding","display_name":"cell rounding","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.6859999895095825},{"id":"https://openalex.org/keywords/thermal-resistance","display_name":"thermal resistance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/heat-induced-cell-death","display_name":"heat-induced cell death","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.7419909238815308},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7025433778762817},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6021659970283508},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5114201903343201},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.4879400432109833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4773164689540863},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40363436937332153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3229827284812927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32066506147384644},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1730840504169464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2307/3576053","doi":"https://doi.org/10.2307/3576053","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3576053","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:6718697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6718697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W88870177","https://openalex.org/W1491431499","https://openalex.org/W1521931452","https://openalex.org/W1524760477","https://openalex.org/W1581959582","https://openalex.org/W1589415602","https://openalex.org/W1606423922","https://openalex.org/W1626967392","https://openalex.org/W1816510217","https://openalex.org/W1866373219","https://openalex.org/W1966554865","https://openalex.org/W1966907932","https://openalex.org/W1972299176","https://openalex.org/W1973114748","https://openalex.org/W1980320649","https://openalex.org/W1981387897","https://openalex.org/W1998784674","https://openalex.org/W2006309842","https://openalex.org/W2008807988","https://openalex.org/W2010021658","https://openalex.org/W2011607607","https://openalex.org/W2019464701","https://openalex.org/W2021504472","https://openalex.org/W2027173346","https://openalex.org/W2031586145","https://openalex.org/W2039188025","https://openalex.org/W2045416392","https://openalex.org/W2046124432","https://openalex.org/W2046826725","https://openalex.org/W2047528139","https://openalex.org/W2055656243","https://openalex.org/W2056361536","https://openalex.org/W2061668125","https://openalex.org/W2063753069","https://openalex.org/W2070398607","https://openalex.org/W2076936056","https://openalex.org/W2081348514","https://openalex.org/W2092713432","https://openalex.org/W2098840785","https://openalex.org/W2105423029","https://openalex.org/W2107774451","https://openalex.org/W2110282433","https://openalex.org/W2130249954","https://openalex.org/W2418393334"],"related_works":["https://openalex.org/W2041802983","https://openalex.org/W2061668125","https://openalex.org/W2146873386","https://openalex.org/W2045932467","https://openalex.org/W2219740062","https://openalex.org/W1550057284","https://openalex.org/W1966907932","https://openalex.org/W2107774451","https://openalex.org/W2110341621","https://openalex.org/W2515728072"],"abstract_inverted_index":{"Heat":[0],"treatment":[1,64],"at":[2,32],"42":[3],"degrees":[4,34],"C":[5,35],"of":[6,18,21,28,41,45,51,77,85],"cultured":[7],"Reuber":[8],"H35":[9],"rat":[10],"hepatoma":[11],"cells":[12,58],"induced":[13],"both":[14],"a":[15,38,60,63],"rapid":[16],"decrease":[17],"the":[19,25,29,42,49,55,89],"rate":[20],"protein":[22,46,86],"synthesis":[23,50,87],"and":[24,48,88],"rounding":[26,95],"up":[27,96],"cells.":[30],"Reincubation":[31],"37":[33],"resulted":[36],"in":[37,75],"gradual":[39],"flattening":[40],"cells,":[43],"resumption":[44],"synthesis,":[47],"heat-shock":[52],"proteins.":[53],"During":[54],"recovery":[56],"period":[57],"developed":[59],"resistance":[61,84],"toward":[62],"which":[65],"otherwise":[66],"should":[67],"lead":[68],"to":[69,92],"heat-induced":[70],"cell":[71,78],"death.":[72],"Thermotolerance":[73],"measured":[74],"terms":[76],"survival":[79],"was":[80],"paralleled":[81],"by":[82],"thermal":[83],"cellular":[90],"ability":[91],"refrain":[93],"from":[94],"under":[97],"heat":[98],"stress.":[99]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
