{"id":"https://openalex.org/W2322016289","doi":"https://doi.org/10.1021/jm401508p","title":"Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells","display_name":"Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells","publication_year":2014,"publication_date":"2014-01-04","ids":{"openalex":"https://openalex.org/W2322016289","doi":"https://doi.org/10.1021/jm401508p","mag":"2322016289","pmid":"https://pubmed.ncbi.nlm.nih.gov/24387105"},"language":"en","primary_location":{"id":"doi:10.1021/jm401508p","doi":"https://doi.org/10.1021/jm401508p","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm401508p","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm401508p","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/jm401508p","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018856405","display_name":"Bibek Parajuli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibek Parajuli","raw_affiliation_strings":["Indiana University School of Medicine , , , ,","Department\rof Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine , , , ,","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department\rof Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055500811","display_name":"Melissa L. Fishel","orcid":"https://orcid.org/0000-0002-9436-6382","observed_orcids":["https://orcid.org/0000-0002-9436-6382"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. Fishel","raw_affiliation_strings":["Indiana University School of Medicine , , , ,","Department\rof Pediatrics, Pharmacology and Toxicology, Herman B. Wells Center\rfor Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","Department\rof Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine , , , ,","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department\rof Pediatrics, Pharmacology and Toxicology, Herman B. Wells Center\rfor Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department\rof Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031403355","display_name":"Thomas D. Hurley","orcid":"https://orcid.org/0000-0002-5942-1163","observed_orcids":["https://orcid.org/0000-0002-5942-1163"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas D. Hurley","raw_affiliation_strings":["Indiana University School of Medicine , , , ,","Department\rof Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine , , , ,","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department\rof Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031403355"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.4339,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.89871292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"57","issue":"2","first_page":"449","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldh3a1","display_name":"ALDH3A1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase-inhibition","display_name":"aldehyde dehydrogenase inhibition","score":0.9120000004768372},{"id":"https://openalex.org/keywords/benzimidazole-analogues","display_name":"benzimidazole analogues","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mafosfamide","display_name":"mafosfamide","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.6840000152587891},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/xenobiotic-detoxification","display_name":"xenobiotic detoxification","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8899643421173096},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.851681113243103},{"id":"https://openalex.org/C2778484023","wikidata":"https://www.wikidata.org/wiki/Q415190","display_name":"Benzimidazole","level":2,"score":0.5585910677909851},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4146636724472046},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3137599229812622},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09784141182899475}],"mesh":[{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000444","descriptor_name":"Aldehyde Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1021/jm401508p","doi":"https://doi.org/10.1021/jm401508p","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm401508p","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm401508p","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:24387105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24387105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3253146","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3988914","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3988914","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3988914","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.791.9911","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.791.9911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/41/bc/jm401508p.PMC3988914.pdf","raw_type":"text"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/8479","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/8479","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publisher","raw_type":"Article"},{"id":"mag:3020872403","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.iupui.edu/handle/1805/8479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525035","display_name":"Publisher","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"Publisher","raw_type":null},{"id":"doi:10.7270/q2vt1tkk","doi":"https://doi.org/10.7270/q2vt1tkk","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2vt1tkk","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1021/jm401508p","doi":"https://doi.org/10.1021/jm401508p","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm401508p","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm401508p","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1628476732","display_name":null,"funder_award_id":"P30CA 082709","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2588474362","display_name":null,"funder_award_id":"R21 AA019746","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5782548348","display_name":"X8 Prospector for Macromolecular Crystallography","funder_award_id":"S10RR027281","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5963923960","display_name":null,"funder_award_id":"R01AA019746","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000232065","display_name":null,"funder_award_id":"R01-AA019746","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G932658672","display_name":"Activation and Inhibition of Aldehyde Dehydrogenase 2","funder_award_id":"R01AA018123","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2322016289.pdf","grobid_xml":"https://content.openalex.org/works/W2322016289.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W27326089","https://openalex.org/W140704135","https://openalex.org/W1484196488","https://openalex.org/W1525055187","https://openalex.org/W1544906050","https://openalex.org/W1920742048","https://openalex.org/W1965520267","https://openalex.org/W1973255896","https://openalex.org/W1982628372","https://openalex.org/W1993758973","https://openalex.org/W1998794592","https://openalex.org/W2004336017","https://openalex.org/W2007792880","https://openalex.org/W2008018303","https://openalex.org/W2008737688","https://openalex.org/W2009641012","https://openalex.org/W2019774245","https://openalex.org/W2020935845","https://openalex.org/W2021816606","https://openalex.org/W2021952312","https://openalex.org/W2031294163","https://openalex.org/W2047244107","https://openalex.org/W2049831025","https://openalex.org/W2052902127","https://openalex.org/W2055930161","https://openalex.org/W2057099146","https://openalex.org/W2061859994","https://openalex.org/W2069616058","https://openalex.org/W2073656127","https://openalex.org/W2076537660","https://openalex.org/W2077657779","https://openalex.org/W2082395080","https://openalex.org/W2086629541","https://openalex.org/W2090049751","https://openalex.org/W2092150545","https://openalex.org/W2103503400","https://openalex.org/W2114622716","https://openalex.org/W2117708806","https://openalex.org/W2119859850","https://openalex.org/W2120197945","https://openalex.org/W2123663162","https://openalex.org/W2132810296","https://openalex.org/W2133430090","https://openalex.org/W2137102572","https://openalex.org/W2144081223","https://openalex.org/W2146080841","https://openalex.org/W2154109796","https://openalex.org/W2155543018","https://openalex.org/W2159211495","https://openalex.org/W2159796173","https://openalex.org/W2165497032","https://openalex.org/W2180229411","https://openalex.org/W2386251952","https://openalex.org/W2950273868","https://openalex.org/W4316093142"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"Aldehyde":[0],"dehydrogenase":[1],"enzymes":[2],"irreversibly":[3],"oxidize":[4],"aldehydes":[5],"generated":[6],"from":[7],"metabolism":[8],"of":[9,53,72,78,83,111,130],"amino":[10],"acids,":[11,13],"fatty":[12],"food,":[14],"smoke,":[15],"additives,":[16],"and":[17,48,69,99,116],"xenobiotic":[18,24],"drugs.":[19],"Cyclophosphamide":[20],"is":[21],"one":[22],"such":[23],"used":[25],"in":[26,60,126],"cancer":[27],"therapies.":[28],"Upon":[29],"activation,":[30],"cyclophosphamide":[31,59],"forms":[32],"an":[33],"intermediate,":[34],"aldophosphamide,":[35],"which":[36],"can":[37],"be":[38],"detoxified":[39],"to":[40,106],"carboxyphosphamide":[41],"by":[42],"aldehyde":[43,108],"dehydrogenases":[44],"(ALDH),":[45],"especially":[46],"ALDH1A1":[47],"ALDH3A1.":[49,112],"Consequently,":[50],"selective":[51,75],"inhibition":[52],"ALDH3A1":[54,61,137],"could":[55],"increase":[56],"chemosensitivity":[57],"toward":[58,122],"expressing":[62],"tumors.":[63],"Here,":[64],"we":[65],"report":[66],"detailed":[67],"kinetics":[68],"structural":[70],"characterization":[71],"a":[73],"highly":[74],"submicromolar":[76],"inhibitor":[77],"ALDH3A1,":[79],"1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole":[80],"(CB7,":[81],"IC50":[82],"0.2":[84],"\u03bcM).":[85],"CB7":[86,104],"does":[87],"not":[88],"inhibit":[89],"ALDH1A1,":[90],"ALDH1A2,":[91],"ALDH1A3,":[92],"ALDH1B1,":[93],"or":[94],"ALDH2":[95],"activity.":[96],"Structural,":[97],"kinetics,":[98],"mutagenesis":[100],"studies":[101],"show":[102],"that":[103],"binds":[105],"the":[107,127],"binding":[109],"pocket":[110],"ALDH3A1-expressing":[113],"lung":[114,134],"adenocarcinoma":[115],"glioblastoma":[117],"cell":[118],"lines":[119],"are":[120,139],"sensitized":[121],"mafosfamide":[123],"(MF)":[124],"treatment":[125],"presence":[128],"analogues":[129],"CB7,":[131],"whereas":[132],"primary":[133],"fibroblasts":[135],"lacking":[136],"expression,":[138],"not.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}