{"id":"https://openalex.org/W2322010338","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","title":"Development of Predictive Models for Airflow Obstruction in Alpha-1 Antitrypsin Deficiency.","display_name":"Development of Predictive Models for Airflow Obstruction in Alpha-1 Antitrypsin Deficiency.","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2322010338","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","mag":"2322010338"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B62. ALPHA-1 ANTITRYPSIN: MOLECULAR, EPIDEMIOLOGICAL, AND CLINICAL FEATURES IN 2009","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058359938","display_name":"Peter J. Castaldi","orcid":"https://orcid.org/0000-0001-9920-4713","observed_orcids":["https://orcid.org/0000-0001-9920-4713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PJ Castaldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011734081","display_name":"D.L. DeMeo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DL Demeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012623801","display_name":"DM Kent","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DM Kent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109324746","display_name":"Campbell Ej","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EJ Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"AJ Barker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AJ Barker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022549865","display_name":"ML Brantly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ML Brantly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028838326","display_name":"E. Ed\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EE Eden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535949","display_name":"Noel Gerard McElvaney","orcid":"https://orcid.org/0000-0002-0152-4370","observed_orcids":["https://orcid.org/0000-0002-0152-4370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NG McElvaney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083270547","display_name":"Stephen I. Rennard","orcid":"https://orcid.org/0000-0001-7909-0253","observed_orcids":["https://orcid.org/0000-0001-7909-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SI Rennard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031441053","display_name":"JM Stocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JM Stocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112155545","display_name":"James K Stoller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JK Stoller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006886866","display_name":"Charlie Strange","orcid":"https://orcid.org/0000-0002-8109-8067","observed_orcids":["https://orcid.org/0000-0002-8109-8067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Strange","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108462067","display_name":"Gerard M. Turino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Turino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009062375","display_name":"RA Sandhaus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RA Sandhaus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038050889","display_name":"JL Griffith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JL Griffith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EK Silverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A3499","last_page":"A3499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin-deficiency","display_name":"alpha-1 antitrypsin deficiency","score":0.9929999709129333},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9259999990463257},{"id":"https://openalex.org/keywords/fev1-prediction","display_name":"FEV1 prediction","score":0.7639999985694885},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.5609999895095825},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.550000011920929},{"id":"https://openalex.org/keywords/bronchodilator-responsiveness","display_name":"bronchodilator responsiveness","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chronic-bronchitis","display_name":"chronic bronchitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/family-studies","display_name":"family studies","score":0.6980000138282776},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8598296642303467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7063249349594116},{"id":"https://openalex.org/C2992694001","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Chronic bronchitis","level":2,"score":0.6838930249214172},{"id":"https://openalex.org/C2780535462","wikidata":"https://www.wikidata.org/wiki/Q622437","display_name":"Alpha 1-antitrypsin deficiency","level":2,"score":0.6674569845199585},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5891437530517578},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5359590649604797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5115876793861389},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.21293282508850098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13416162133216858},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06624341011047363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","doi":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3499","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"B62. ALPHA-1 ANTITRYPSIN: MOLECULAR, EPIDEMIOLOGICAL, AND CLINICAL FEATURES IN 2009","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166236948","https://openalex.org/W2129772311","https://openalex.org/W4292769351","https://openalex.org/W2562499368","https://openalex.org/W2990280826","https://openalex.org/W1979881533","https://openalex.org/W4362657360","https://openalex.org/W1541668931","https://openalex.org/W2071493384","https://openalex.org/W2003378221"],"abstract_inverted_index":{"Alpha-1-antitrypsin":[0],"deficiency":[1],"is":[2,17],"a":[3,53],"genetic":[4,91],"condition":[5],"associated":[6],"with":[7,26,62],"severe,":[8],"early-onset":[9],"chronic":[10,135,179],"obstructive":[11,180],"pulmonary":[12,177],"disease":[13,42],"(COPD).":[14],"However,":[15],"there":[16],"significant":[18],"variability":[19],"in":[20,46,77,156],"lung":[21,41],"function":[22],"impairment":[23],"among":[24],"persons":[25,35,61],"the":[27,63,68,82,95,104,113,143,146,154,159],"protease":[28,64],"inhibitor":[29,65],"ZZ":[30,66],"genotype.":[31],"Early":[32],"identification":[33],"of":[34,39,59,84,94,121,131,153],"at":[36],"highest":[37],"risk":[38],"developing":[40],"could":[43],"be":[44,119],"beneficial":[45],"guiding":[47],"monitoring":[48],"and":[49,81,90,103,124,138,158],"treatment":[50],"decisions.":[51],"Using":[52],"multicenter,":[54],"family-based":[55],"study":[56],"sample":[57,97],"(2002\u20132005)":[58],"372":[60],"genotype,":[67],"authors":[69],"developed":[70],"prediction":[71],"models":[72],"for":[73,100,109,149,161],"forced":[74],"expiratory":[75],"volume":[76],"1":[78],"second":[79],"(FEV1)":[80],"presence":[83],"severe":[85,125,162],"COPD":[86,126,163],"using":[87],"demographic,":[88],"clinical,":[89],"variables.":[92],"Half":[93],"data":[96],"was":[98,107],"used":[99,108],"model":[101,110,148,160],"development,":[102],"other":[105],"half":[106],"validation.":[111],"In":[112,142],"training":[114],"sample,":[115,145],"variables":[116],"found":[117],"to":[118],"predictive":[120,147],"both":[122],"FEV1":[123,150],"were":[127],"age,":[128],"sex,":[129],"pack-years":[130],"smoking,":[132],"bronchodilator":[133],"responsiveness,":[134],"bronchitis":[136],"symptoms,":[137],"index":[139],"case":[140],"status.":[141],"validation":[144],"explained":[151],"50%":[152],"variance":[155],"FEV1,":[157],"exhibited":[164],"excellent":[165],"discrimination":[166],"(c":[167],"statistic":[168],"\u00bc":[169],"0.88).":[170],"alpha-1-antitrypsin":[171],"deficiency;":[172],"genetics;":[173],"polymorphism,":[174],"single":[175],"nucleotide;":[176],"disease,":[178]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
