{"id":"https://openalex.org/W2321994053","doi":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","title":"The Acute-Phase Response in Relation to Radiographic Progression in Early Rheumatoid Arthritis: A Prospective Study During the First Three Years of the Disease","display_name":"The Acute-Phase Response in Relation to Radiographic Progression in Early Rheumatoid Arthritis: A Prospective Study During the First Three Years of the Disease","publication_year":1993,"publication_date":"1993-06-17","ids":{"openalex":"https://openalex.org/W2321994053","doi":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","mag":"2321994053","pmid":"https://pubmed.ncbi.nlm.nih.gov/8508266"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/32.suppl_3.9","doi":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110103743","display_name":"Miek A. Van Leeuwen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. A. van Leeuwen","raw_affiliation_strings":["Department of Rheumatology, University Hospital, Groningen, The Netherlands","*Department of Rheumatology, University HospitalGroningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University Hospital, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]},{"raw_affiliation_string":"*Department of Rheumatology, University HospitalGroningen","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032636046","display_name":"M. H. van Rijswijk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M. H. van Rijswijk","raw_affiliation_strings":["Department of Rheumatology, University Hospital Groningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University Hospital Groningen","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104506506","display_name":"D\u00e9sir\u00e9e M F M van der Heijde","orcid":"https://orcid.org/0000-0002-5781-158X","observed_orcids":["https://orcid.org/0000-0002-5781-158X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. M. F. M. van der Heijde","raw_affiliation_strings":["\u2020 Department of Rheumatology, University Hospital Nijmegen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Rheumatology, University Hospital Nijmegen","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028952389","display_name":"Gerard J. te Meerman","orcid":"https://orcid.org/0000-0002-5615-8304","observed_orcids":["https://orcid.org/0000-0002-5615-8304"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G. J. T. Meerman","raw_affiliation_strings":["\u2021Institute of Medical Genetics, University of GroningenGroningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Institute of Medical Genetics, University of GroningenGroningen","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076651742","display_name":"Piet L. C. M. van Riel","orcid":"https://orcid.org/0000-0001-7719-8906","observed_orcids":["https://orcid.org/0000-0001-7719-8906"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. L. C. M. van Riel","raw_affiliation_strings":["\u2020 Department of Rheumatology, University Hospital Nijmegen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Rheumatology, University Hospital Nijmegen","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028405422","display_name":"P. M. Houtman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802652803","display_name":"Medisch Centrum Leeuwarden","ror":"https://ror.org/0283nw634","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802652803","https://openalex.org/I4405259012"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. M. Houtman","raw_affiliation_strings":["\u00a7 Department of Rheumatology, Medical Centre Leeuwarden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7 Department of Rheumatology, Medical Centre Leeuwarden, The Netherlands","institution_ids":["https://openalex.org/I2802652803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110253654","display_name":"L. B. A. van de Putte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. B. A. van de Putte","raw_affiliation_strings":["\u2020 Department of Rheumatology, University Hospital Nijmegen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Rheumatology, University Hospital Nijmegen","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113662840","display_name":"Pieter C Limburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. C. Limburg","raw_affiliation_strings":["Department of Rheumatology, University Hospital Groningen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, University Hospital Groningen","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032636046"],"corresponding_institution_ids":["https://openalex.org/I1334415907"],"apc_list":{"value":3486,"currency":"GBP","value_usd":4597},"apc_paid":null,"fwci":5.4856,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.96523266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"32","issue":"suppl 3","first_page":"9","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.9139999747276306},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9319999814033508},{"id":"https://openalex.org/keywords/radiographic-progression","display_name":"radiographic progression","score":0.8199999928474426},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.953000009059906},{"id":"https://openalex.org/keywords/modified-sharp-score","display_name":"modified Sharp score","score":0.5809999704360962},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.75},{"id":"https://openalex.org/keywords/hla-dr4","display_name":"HLA-DR4","score":0.878000020980835},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"rheumatoid factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/serial-biomarker-monitoring","display_name":"serial biomarker measurement","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9296109676361084},{"id":"https://openalex.org/C190892606","wikidata":"https://www.wikidata.org/wiki/Q3512464","display_name":"Radiological weapon","level":2,"score":0.8779866099357605},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6679888963699341},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.564637303352356},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.5538981556892395},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.48681017756462097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4863069951534271},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4104682505130768},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3083299398422241},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000210","descriptor_name":"Acute-Phase Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/rheumatology/32.suppl_3.9","doi":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","is_oa":false,"landing_page_url":"https://doi.org/10.1093/rheumatology/32.suppl_3.9","pdf_url":null,"source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmid:8508266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8508266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of rheumatology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:rheumatology:32/3/9","doi":null,"is_oa":false,"landing_page_url":"http://rheumatology.oxfordjournals.org/cgi/content/short/32/3/9","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2576786590","https://openalex.org/W7010530034","https://openalex.org/W1993187465","https://openalex.org/W2390906597","https://openalex.org/W4393081073","https://openalex.org/W2171505815","https://openalex.org/W235284992","https://openalex.org/W3125879978","https://openalex.org/W2343238799","https://openalex.org/W4320148678"],"abstract_inverted_index":{"Studies":[0],"on":[1],"the":[2,32,46,49,52,56,95,148,171,180,193,201,206],"relationship":[3,47],"between":[4,48,126],"acute-phase":[5,53],"protein":[6],"(APP)":[7],"production,":[8],"clinical":[9],"disease":[10],"activity":[11],"and":[12,42,55,129],"progression":[13,57,102,184],"of":[14,31,51,58,67,84,98,151,174,177,182,192,203,208],"radiological":[15,59,101,130,183],"damage":[16,60,210],"in":[17,45,147,205],"RA":[18,77],"have":[19],"been":[20],"hampered":[21],"by":[22,112,162],"three":[23,87],"factors:":[24],"patients":[25,75],"are":[26,36,61],"studied":[27],"at":[28,85],"different":[29],"stages":[30],"disease;":[33],"APP":[34,107],"levels":[35,116],"taken":[37],"incidentally":[38],"rather":[39],"than":[40],"serially;":[41],"inter-individual":[43,140,155,189,197],"differences":[44,198],"extent":[50],"reaction":[54],"not":[62,158],"accounted":[63,160],"for.":[64],"A":[65],"group":[66],"110":[68],"newly":[69],"diagnosed":[70],"(complaints":[71],"<":[72],"1":[73],"year)":[74],"with":[76],"were":[78],"analysed":[79],"for":[80,161,179,211],"a":[81,104,120,133],"follow-up":[82],"period":[83],"least":[86],"years.":[88],"Damage":[89],"was":[90,109,124,136,145],"assessed":[91],"radiologically":[92],"according":[93],"to":[94,139,188],"modified":[96],"method":[97],"Sharp.":[99],"As":[100],"is":[103,185],"cumulative":[105],"event,":[106],"production":[108,128],"also":[110],"calculated":[111],"plotting":[113],"serial":[114,175],"CRP":[115,127,152,204],"over":[117],"time.":[118],"Overall,":[119],"highly":[121],"significant":[122],"correlation":[123],"found":[125,146],"progression;":[131],"however,":[132],"wide":[134],"variation":[135,144,156],"observed":[137],"due":[138,187],"differences.":[141],"The":[142],"greatest":[143],"lower":[149],"range":[150],"values,":[153],"where":[154],"could":[157],"be":[159],"HLA-DR4,":[163],"positive":[164],"RF,":[165],"sex":[166],"or":[167],"age.":[168],"In":[169],"conclusion,":[170],"prognostic":[172],"use":[173],"measurement":[176],"APPs":[178],"assessment":[181],"limited":[186],"variation.":[190],"Knowledge":[191],"factors":[194],"underlying":[195],"these":[196],"will":[199],"increase":[200],"applicability":[202],"prediction":[207],"joint":[209],"individual":[212],"patients.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
