{"id":"https://openalex.org/W2321986179","doi":"https://doi.org/10.1242/jcs.141283","title":"Dynamic analysis of Arabidopsis AP2 \u03c3 subunit reveals a key role in clathrin-mediated endocytosis and plant development","display_name":"Dynamic analysis of Arabidopsis AP2 \u03c3 subunit reveals a key role in clathrin-mediated endocytosis and plant development","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2321986179","doi":"https://doi.org/10.1242/jcs.141283","mag":"2321986179"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.141283","doi":"https://doi.org/10.1242/jcs.141283","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.141283","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052422222","display_name":"Lusheng Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lusheng Fan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016723885","display_name":"Huaiqing Hao","orcid":"https://orcid.org/0000-0003-0653-0021","observed_orcids":["https://orcid.org/0000-0003-0653-0021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huaiqing Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050130189","display_name":"Yiqun Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiqun Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425282","display_name":"Liang N. Zhang","orcid":"https://orcid.org/0000-0003-3100-8593","observed_orcids":["https://orcid.org/0000-0003-3100-8593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069524933","display_name":"Zhaojun Ding","orcid":"https://orcid.org/0000-0003-0218-5136","observed_orcids":["https://orcid.org/0000-0003-0218-5136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaojun Ding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032049889","display_name":"Miguel A. Botella","orcid":"https://orcid.org/0000-0002-8867-1831","observed_orcids":["https://orcid.org/0000-0002-8867-1831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel A. Botella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438279","display_name":"Haiyang Wang","orcid":"https://orcid.org/0000-0002-1302-5747","observed_orcids":["https://orcid.org/0000-0002-1302-5747","https://orcid.org/0009-0001-4605-4587","https://orcid.org/0009-0004-1351-1683","https://orcid.org/0009-0009-3262-5906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haiyang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004317300","display_name":"Jinxing Lin","orcid":"https://orcid.org/0000-0001-9338-1356","observed_orcids":["https://orcid.org/0000-0001-9338-1356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinxing Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16888074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"18","first_page":"e1","last_page":"e1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/ap2","display_name":"AP-2","score":0.824999988079071},{"id":"https://openalex.org/keywords/clathrin-light-chain","display_name":"clathrin light chain","score":0.9340000152587891},{"id":"https://openalex.org/keywords/auxin-transport","display_name":"auxin transport","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pin1","display_name":"Pin1","score":0.6290000081062317},{"id":"https://openalex.org/keywords/polar-auxin-transport","display_name":"polar auxin transport","score":0.9549999833106995},{"id":"https://openalex.org/keywords/auxin-signaling","display_name":"auxin signaling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/plant-development","display_name":"plant development","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cotyledon-morphology","display_name":"cotyledon morphology","score":0.8349999785423279},{"id":"https://openalex.org/keywords/vascular-patterns","display_name":"vascular patterns","score":0.6119999885559082},{"id":"https://openalex.org/keywords/silique-development","display_name":"silique development","score":0.9350000023841858},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.7400000095367432},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.5860000252723694},{"id":"https://openalex.org/keywords/protein-recycling","display_name":"protein recycling","score":0.49300000071525574},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8519529104232788},{"id":"https://openalex.org/C63162447","wikidata":"https://www.wikidata.org/wiki/Q21100804","display_name":"Clathrin","level":4,"score":0.7657859921455383},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7569103837013245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7550788521766663},{"id":"https://openalex.org/C26659971","wikidata":"https://www.wikidata.org/wiki/Q729923","display_name":"Fluorescence recovery after photobleaching","level":3,"score":0.6819822788238525},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5163518190383911},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.4884861707687378},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4329240918159485},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.41982126235961914},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41108202934265137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20481538772583008},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08860138058662415},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1242/jcs.141283","doi":"https://doi.org/10.1242/jcs.141283","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.141283","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2154437831"],"related_works":["https://openalex.org/W2136166919","https://openalex.org/W2346675990","https://openalex.org/W6929377172","https://openalex.org/W2134611522","https://openalex.org/W2147174583","https://openalex.org/W4410471043","https://openalex.org/W2138404754","https://openalex.org/W2358333442","https://openalex.org/W2104766562","https://openalex.org/W2792436561"],"abstract_inverted_index":{"Clathrin-mediated":[0],"endocytosis,":[1,228],"which":[2,223],"depends":[3],"on":[4],"the":[5,22,25,39,94,130,150,157,166,171,182,187,198,214],"AP2":[6,26,40,85,123,135,211,219],"complex,":[7],"plays":[8],"an":[9,207],"essential":[10,208],"role":[11,209],"in":[12,18,28,36,58,99,156,181,197,213,221],"many":[13],"cellular":[14],"and":[15,66,78,90,109,133,139,146,163,170,232],"developmental":[16,48],"processes":[17],"mammalian":[19],"cells.":[20],"However,":[21],"function":[23],"of":[24,55,149,165,190,210,216],"complex":[27,220],"plants":[29],"remains":[30],"largely":[31],"unexplored.":[32],"Here,":[33],"we":[34,120],"show":[35,121],"Arabidopsis":[37],"that":[38,50,84,122,134],"\u03c3":[41,86,159,184,200,212],"subunit":[42],"mutant":[43],"(ap2":[44],"\u03c3)":[45],"displays":[46],"various":[47],"defects":[49],"are":[51,153,177],"similar":[52],"to":[53],"those":[54],"mutants":[56],"defective":[57,75],"auxin":[59,172,230],"transport":[60,231],"and/or":[61],"signaling,":[62],"including":[63],"single,":[64],"trumpet-shaped":[65],"triple":[67],"cotyledons,":[68],"impaired":[69],"vascular":[70],"pattern,":[71],"reduced":[72,80,155,180],"vegetative":[73],"growth,":[74],"silique":[76],"development":[77],"drastically":[79],"fertility.":[81],"We":[82],"demonstrate":[83],"is":[87,192,224],"closely":[88],"associated":[89],"physically":[91],"interacts":[92],"with":[93,127],"clathrin":[95],"light":[96],"chain":[97],"(CLC)":[98],"vivo":[100],"using":[101],"fluorescence":[102,117,137],"cross-correlation":[103],"spectroscopy":[104],"(FCCS),":[105],"protein":[106,175],"proximity":[107],"analyses":[108],"co-immunoprecipitation":[110],"assays.":[111],"Using":[112],"variable-angle":[113],"total":[114],"internal":[115],"reflection":[116],"microscopy":[118],"(VA-TIRFM),":[119],"\u03c3-mCherry":[124,136],"spots":[125,152],"colocalize":[126],"CLC-EGFP":[128,142,151],"at":[129],"plasma":[131],"membrane,":[132],"appears":[138],"disappears":[140],"before":[141],"fluorescence.":[143],"The":[144,161],"density":[145],"turnover":[147],"rate":[148],"significantly":[154,179,193],"ap2":[158,183,199],"mutant.":[160,185,201],"internalization":[162],"recycling":[164],"endocytic":[167],"tracer":[168],"FM4-64":[169],"efflux":[173],"carrier":[174],"PIN1":[176],"also":[178],"Further,":[186],"polar":[188,229],"localization":[189],"PIN1-GFP":[191],"disrupted":[194],"during":[195],"embryogenesis":[196],"Taken":[202],"together,":[203],"our":[204],"results":[205],"support":[206],"assembly":[215],"a":[217],"functional":[218],"plants,":[222],"required":[225],"for":[226],"clathrin-mediated":[227],"plant":[233],"growth":[234],"regulation.":[235]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}