{"id":"https://openalex.org/W2321978357","doi":"https://doi.org/10.3181/00379727-211-43956","title":"Age-Related Effects of Ectopic Pituitary Transplants on the Activation of Ames Dwarf Mouse Lymphocytes In Vitro","display_name":"Age-Related Effects of Ectopic Pituitary Transplants on the Activation of Ames Dwarf Mouse Lymphocytes In Vitro","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2321978357","doi":"https://doi.org/10.3181/00379727-211-43956","mag":"2321978357","pmid":"https://pubmed.ncbi.nlm.nih.gov/8594624"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-211-43956","doi":"https://doi.org/10.3181/00379727-211-43956","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-211-43956","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048819283","display_name":"Ana Isabel Esquifino","orcid":"https://orcid.org/0000-0002-1625-7615","observed_orcids":["https://orcid.org/0000-0002-1625-7615"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. I. Esquifino","raw_affiliation_strings":["Departmento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain","Departmento de Bioquimica y Biologia Molecular III, Facultad de Medicin\u00e1, Universidad Complutense, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Departmento de Bioquimica y Biologia Molecular III, Facultad de Medicin\u00e1, Universidad Complutense, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021795746","display_name":"A Szary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Szary","raw_affiliation_strings":["Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201","institution_ids":["https://openalex.org/I110378019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088865929","display_name":"Holly M. Brown\u2010Borg","orcid":"https://orcid.org/0000-0001-7415-4617","observed_orcids":["https://orcid.org/0000-0001-7415-4617"]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. M. Brown-Borg","raw_affiliation_strings":["Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201","institution_ids":["https://openalex.org/I110378019"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111882231","display_name":"Andrzej Bartke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Bartke","raw_affiliation_strings":["Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois, 69201","institution_ids":["https://openalex.org/I110378019"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.5343,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.67233456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"211","issue":"1","first_page":"87","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pituitary-transplantation","display_name":"pituitary transplantation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/splenocyte-proliferation","display_name":"splenocyte proliferation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.652999997138977},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.5270000100135803},{"id":"https://openalex.org/keywords/prolactin-deficiency","display_name":"prolactin deficiency","score":0.6669999957084656},{"id":"https://openalex.org/keywords/mitogenic-stimulation","display_name":"mitogen stimulation","score":0.40799999237060547},{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.6970000267028809},{"id":"https://openalex.org/keywords/phytohemagglutinin","display_name":"phytohemagglutinin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-markers","display_name":"T-cell markers","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.6796067953109741},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6627904772758484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6574941873550415},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6499935388565063},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.6221663355827332},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5917022824287415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5854240655899048},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5463689565658569},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5080795288085938},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.45934492349624634},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42187511920928955},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27260851860046387},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2708716094493866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22261810302734375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004392","descriptor_name":"Dwarfism","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016042","descriptor_name":"Transplantation, Heterotopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-211-43956","doi":"https://doi.org/10.3181/00379727-211-43956","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-211-43956","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:8594624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8594624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G125304148","display_name":"PHYSIOLOGICAL ROLE OF GROWTH HORMONE IN THE MALE","funder_award_id":"5r01hd020033-12","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1930859166","display_name":null,"funder_award_id":"HD-20033","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G387474655","display_name":"PROLACTIN AND PROLACTIN RECEPTORS IN LYMPHOCYTES","funder_award_id":"5f32ai008745-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G785929027","display_name":null,"funder_award_id":"1F32 AI08745-01A1","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076057632","https://openalex.org/W2048592156","https://openalex.org/W2082347623","https://openalex.org/W2081711632","https://openalex.org/W1497260894","https://openalex.org/W2352784251","https://openalex.org/W2086454249","https://openalex.org/W2086453583","https://openalex.org/W576370152","https://openalex.org/W1972368751"],"abstract_inverted_index":{"Prolactin":[0],"(PRL),":[1],"one":[2],"of":[3,16,29,160,172,182,192,196,206,221,255,264,288,291,318,379,384,407,415],"the":[4,12,40,67,104,164,189,253,261,377,381],"anterior":[5],"pituitary":[6,65,85,201,283,397],"hormones,":[7],"has":[8],"been":[9],"implicated":[10],"in":[11,35,131,200,215,227,272,276,293,301,307,323,332,343,369,389,421],"development":[13],"and":[14,44,47,88,106,110,124,143,245,266,304,328,365,396,414],"maintenance":[15],"immune":[17,32,430],"system":[18,33,431],"function.":[19],"The":[20,113,127,218],"following":[21,98],"experiments":[22],"were":[23,52,79,101,129,147,166,213,239,269,341],"conducted":[24],"to":[25,92,121,295,348,394],"evaluate":[26],"age-related":[27],"effects":[28,406],"PRL":[30,408,416],"on":[31,429],"activity":[34],"a":[36,62,71,356],"PRL-deficient":[37],"mouse":[38],"model,":[39],"Ames":[41],"dwarf.":[42],"Two-":[43],"ten-month-old":[45],"dwarf":[46,55,161,234,244,274,427],"phenotypically":[48],"normal":[49,72,108,246,277,312],"male":[50],"mice":[51,56,109,162,170,278,333,428],"used.":[53],"Six":[54,76],"from":[57,70,103,352],"each":[58],"age":[59,115],"group":[60],"received":[61],"surgically":[63],"implanted":[64],"(under":[66],"kidney":[68],"capsule)":[69],"donor":[73],"female":[74],"mouse.":[75],"different":[77,339],"dwarfs":[78,105,203,303,309,354,391,411],"similarly":[80],"operated":[81,243],"but":[82,279],"had":[83],"no":[84,237],"graft":[86],"inserted":[87],"will":[89,117],"be":[90,119],"referred":[91,120],"as":[93,122,361,371,392,423],"sham-operated":[94,233,273,302,324,353,374,390],"dwarfs.":[95,375],"Three":[96],"weeks":[97],"surgery,":[99],"spleens":[100],"removed":[102],"age-matched":[107],"splenocytes":[111,128,183,193,292,319,351,385],"isolated.":[112],"two":[114],"groups":[116],"subsequently":[118],"\"3-month-old\"":[123],"\"11-month-old\",":[125],"respectively,":[126],"used":[130,148],"mitogen-induced":[132],"(concanavalin":[133],"A":[134,174,297],"(Con":[135],"A);":[136],"phytohemagglutinin":[137],"(PHA);":[138],"lipopolysaccharide":[139],"(LPS))":[140],"proliferation":[141,290,366],"assays,":[142],"histopaque":[144],"isolated":[145],"lymphocytes":[146],"for":[149,179],"T":[150],"cell":[151],"surface":[152],"marker":[153],"determination.":[154],"Pituitary":[155,248],"grafting":[156,249,398],"increased":[157,199,299,368],"body":[158,197],"weights":[159,165],"although":[163],"less":[167],"than":[168,275],"control":[169,207],"independent":[171],"age.":[173],"similar":[175],"pattern":[176],"was":[177,224,298,320,329,367,386],"observed":[178,214,240],"total":[180],"number":[181,191],"per":[184,194],"spleen.":[185],"In":[186,258,314,346,376],"young":[187,422],"animals,":[188,260],"relative":[190,219,262],"gram":[195],"weight":[198],"grafted":[202],"reaching":[204],"values":[205],"mice,":[208,230,235],"whereas":[209],"much":[210],"smaller":[211],"differences":[212,238],"older":[216],"animals.":[217,345],"percentage":[220],"CD4+":[222,265],"cells":[223,268],"reduced":[225,305,357],"(P<0.01)":[226],"3-month-old":[228],"pituitary-grafted":[229,308,370],"compared":[231,310,325,362,372,393,424],"with":[232,311,326,363,373,425],"while":[236],"between":[241],"sham-":[242],"mice.":[247,313],"did":[250],"not":[251,280],"affect":[252],"numbers":[254],"CD8+":[256,267],"cells.":[257],"11-month-old":[259,344],"percentages":[263],"greater":[270,387],"(P<0.05)":[271,300,306,322,358,388],"affected":[281],"by":[282],"grafting.":[284],"At":[285],"3":[286],"months":[287],"age,":[289],"response":[294,347],"Con":[296,349],"contrast,":[315],"PHA":[316],"stimulation":[317],"decreased":[321],"normal,":[327],"still":[330],"lower":[331],"receiving":[334],"an":[335],"ectopic":[336],"pituitary.":[337],"Substantially":[338],"responses":[340],"obtained":[342],"A,":[350],"exhibited":[355],"proliferative":[359,382],"capacity":[360,383],"normals,":[364],"presence":[378],"PHA,":[380],"normals":[395],"normalized":[399],"this":[400],"parameter.":[401],"These":[402],"results":[403],"demonstrate":[404],"differential":[405],"deficiency":[409],"(sham-operated":[410],"versus":[412,419],"normal)":[413],"replacement":[417],"(pituitary-grafted":[418],"sham-operated)":[420],"old":[426],"activation.":[432]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
