{"id":"https://openalex.org/W2321971182","doi":null,"title":"Transcriptional co-regulation of microRNAs and protein-coding genes","display_name":"Transcriptional co-regulation of microRNAs and protein-coding genes","publication_year":2013,"publication_date":"2013-12-04","ids":{"openalex":"https://openalex.org/W2321971182","mag":"2321971182"},"language":"en","primary_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","pdf_url":"https://pure.manchester.ac.uk/ws/files/54545959/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.manchester.ac.uk/ws/files/54545959/FULL_TEXT.PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078604281","display_name":"Aaron Webber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aaron Webber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078604281"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.597000002861023},{"id":"https://openalex.org/keywords/protein-coding-genes","display_name":"protein-coding genes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcriptional-co-regulation","display_name":"transcriptional co-regulation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.906000018119812},{"id":"https://openalex.org/keywords/microrna-genes","display_name":"microRNA genes","score":0.5669999718666077},{"id":"https://openalex.org/keywords/regulatory-feedback-loops","display_name":"feedback regulatory loop","score":0.7870000004768372},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/vervet-monkey","display_name":"vervet monkey","score":0.6919999718666077},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9660000205039978},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7271881699562073},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7125967741012573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6840740442276001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6085993051528931},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5061668753623962},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4900189936161041},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.4857671558856964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.463237464427948},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.41879650950431824},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3809795677661896}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pure.atira.dk:studenttheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","pdf_url":"https://pure.manchester.ac.uk/ws/files/54545959/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},{"id":"mag:2321971182","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677721","pdf_url":null,"source":{"id":"https://openalex.org/S4306532718","display_name":"[Thesis]. Manchester, UK: The University of                    Manchester; 2013.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"[Thesis]. Manchester, UK: The University of Manchester; 2013.","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:studenttheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/studentTheses/f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf","pdf_url":"https://pure.manchester.ac.uk/ws/files/54545959/FULL_TEXT.PDF","source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"synchronisedUnifiedStudentThesis","raw_type":"Phd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321971182.pdf","grobid_xml":"https://content.openalex.org/works/W2321971182.grobid-xml"},"referenced_works_count":256,"referenced_works":["https://openalex.org/W9847061","https://openalex.org/W607574028","https://openalex.org/W920614351","https://openalex.org/W1263422348","https://openalex.org/W1519069460","https://openalex.org/W1520588455","https://openalex.org/W1525160399","https://openalex.org/W1526476439","https://openalex.org/W1600033471","https://openalex.org/W1603793127","https://openalex.org/W1683833991","https://openalex.org/W1884928119","https://openalex.org/W1956319726","https://openalex.org/W1963811831","https://openalex.org/W1964034855","https://openalex.org/W1964497386","https://openalex.org/W1965395430","https://openalex.org/W1968421082","https://openalex.org/W1968458512","https://openalex.org/W1970178087","https://openalex.org/W1970235943","https://openalex.org/W1970276518","https://openalex.org/W1972785590","https://openalex.org/W1973260612","https://openalex.org/W1975437957","https://openalex.org/W1975981804","https://openalex.org/W1976854258","https://openalex.org/W1977098496","https://openalex.org/W1977105782","https://openalex.org/W1977372263","https://openalex.org/W1978520851","https://openalex.org/W1978560967","https://openalex.org/W1979468302","https://openalex.org/W1980207862","https://openalex.org/W1980389572","https://openalex.org/W1980963048","https://openalex.org/W1982444105","https://openalex.org/W1985098845","https://openalex.org/W1985790922","https://openalex.org/W1988037647","https://openalex.org/W1988163167","https://openalex.org/W1988743517","https://openalex.org/W1988894809","https://openalex.org/W1989476041","https://openalex.org/W1990065094","https://openalex.org/W1991007428","https://openalex.org/W1992872742","https://openalex.org/W1992913991","https://openalex.org/W1996212302","https://openalex.org/W1996890755","https://openalex.org/W1996948250","https://openalex.org/W1997241837","https://openalex.org/W2001042507","https://openalex.org/W2001554877","https://openalex.org/W2002995168","https://openalex.org/W2003952411","https://openalex.org/W2004767632","https://openalex.org/W2006348395","https://openalex.org/W2007150582","https://openalex.org/W2009500547","https://openalex.org/W2010945833","https://openalex.org/W2011678998","https://openalex.org/W2013571070","https://openalex.org/W2014064723","https://openalex.org/W2014286894","https://openalex.org/W2014296134","https://openalex.org/W2014320920","https://openalex.org/W2015416439","https://openalex.org/W2016774526","https://openalex.org/W2017020642","https://openalex.org/W2018507242","https://openalex.org/W2019021131","https://openalex.org/W2020541351","https://openalex.org/W2023411042","https://openalex.org/W2024412145","https://openalex.org/W2024477730","https://openalex.org/W2025549697","https://openalex.org/W2026340191","https://openalex.org/W2027085235","https://openalex.org/W2027656953","https://openalex.org/W2028702634","https://openalex.org/W2029275361","https://openalex.org/W2029722028","https://openalex.org/W2030001084","https://openalex.org/W2030362521","https://openalex.org/W2030498876","https://openalex.org/W2032397353","https://openalex.org/W2033583810","https://openalex.org/W2033687160","https://openalex.org/W2034160125","https://openalex.org/W2034594100","https://openalex.org/W2037532701","https://openalex.org/W2037546400","https://openalex.org/W2037686178","https://openalex.org/W2038167014","https://openalex.org/W2038303173","https://openalex.org/W2039634808","https://openalex.org/W2039922463","https://openalex.org/W2039999119","https://openalex.org/W2041825143","https://openalex.org/W2042865509","https://openalex.org/W2043946672","https://openalex.org/W2044107201","https://openalex.org/W2044534561","https://openalex.org/W2044826047","https://openalex.org/W2045402423","https://openalex.org/W2046217999","https://openalex.org/W2046739185","https://openalex.org/W2047604395","https://openalex.org/W2050040190","https://openalex.org/W2050233629","https://openalex.org/W2050502168","https://openalex.org/W2050869737","https://openalex.org/W2051367993","https://openalex.org/W2052210687","https://openalex.org/W2053702430","https://openalex.org/W2054714075","https://openalex.org/W2057692691","https://openalex.org/W2058858066","https://openalex.org/W2059073003","https://openalex.org/W2059995904","https://openalex.org/W2060995975","https://openalex.org/W2061174980","https://openalex.org/W2061664626","https://openalex.org/W2063450941","https://openalex.org/W2065262709","https://openalex.org/W2065498897","https://openalex.org/W2067116931","https://openalex.org/W2072152932","https://openalex.org/W2073008418","https://openalex.org/W2073157961","https://openalex.org/W2075081228","https://openalex.org/W2075956940","https://openalex.org/W2077272518","https://openalex.org/W2077356336","https://openalex.org/W2078455244","https://openalex.org/W2078739770","https://openalex.org/W2078891878","https://openalex.org/W2079130661","https://openalex.org/W2079818955","https://openalex.org/W2080551186","https://openalex.org/W2083245183","https://openalex.org/W2084191969","https://openalex.org/W2085124463","https://openalex.org/W2086038224","https://openalex.org/W2086076478","https://openalex.org/W2086376086","https://openalex.org/W2086400561","https://openalex.org/W2086527757","https://openalex.org/W2086802511","https://openalex.org/W2088558156","https://openalex.org/W2089238459","https://openalex.org/W2089894746","https://openalex.org/W2089956843","https://openalex.org/W2090474217","https://openalex.org/W2090632681","https://openalex.org/W2092348568","https://openalex.org/W2092956492","https://openalex.org/W2093316348","https://openalex.org/W2094949854","https://openalex.org/W2096089653","https://openalex.org/W2098412979","https://openalex.org/W2098664089","https://openalex.org/W2099468911","https://openalex.org/W2101096590","https://openalex.org/W2102749300","https://openalex.org/W2103602373","https://openalex.org/W2103647350","https://openalex.org/W2103890520","https://openalex.org/W2104730528","https://openalex.org/W2106085645","https://openalex.org/W2106929712","https://openalex.org/W2107003257","https://openalex.org/W2107042278","https://openalex.org/W2107268184","https://openalex.org/W2107903949","https://openalex.org/W2109108939","https://openalex.org/W2109136664","https://openalex.org/W2109718483","https://openalex.org/W2110079496","https://openalex.org/W2110937119","https://openalex.org/W2111268021","https://openalex.org/W2111291916","https://openalex.org/W2111666869","https://openalex.org/W2113310577","https://openalex.org/W2115496564","https://openalex.org/W2115837217","https://openalex.org/W2117553644","https://openalex.org/W2117792884","https://openalex.org/W2117991391","https://openalex.org/W2119847512","https://openalex.org/W2122067103","https://openalex.org/W2122595905","https://openalex.org/W2123541473","https://openalex.org/W2124112939","https://openalex.org/W2124637492","https://openalex.org/W2125781825","https://openalex.org/W2126466006","https://openalex.org/W2127081697","https://openalex.org/W2128034264","https://openalex.org/W2128114769","https://openalex.org/W2128731054","https://openalex.org/W2129782645","https://openalex.org/W2130707276","https://openalex.org/W2131535785","https://openalex.org/W2131706188","https://openalex.org/W2133186878","https://openalex.org/W2133484520","https://openalex.org/W2133643484","https://openalex.org/W2134153749","https://openalex.org/W2134400731","https://openalex.org/W2135521893","https://openalex.org/W2136490370","https://openalex.org/W2136654644","https://openalex.org/W2136669014","https://openalex.org/W2136943892","https://openalex.org/W2136991248","https://openalex.org/W2137505881","https://openalex.org/W2138664009","https://openalex.org/W2138776905","https://openalex.org/W2139030718","https://openalex.org/W2139451625","https://openalex.org/W2141856214","https://openalex.org/W2142976423","https://openalex.org/W2144758891","https://openalex.org/W2145025818","https://openalex.org/W2145283451","https://openalex.org/W2147346503","https://openalex.org/W2149146453","https://openalex.org/W2149233571","https://openalex.org/W2149385968","https://openalex.org/W2149785901","https://openalex.org/W2149920358","https://openalex.org/W2150240056","https://openalex.org/W2150904790","https://openalex.org/W2152720366","https://openalex.org/W2153452535","https://openalex.org/W2154294588","https://openalex.org/W2154766594","https://openalex.org/W2155131748","https://openalex.org/W2155396586","https://openalex.org/W2158217645","https://openalex.org/W2158610627","https://openalex.org/W2158948118","https://openalex.org/W2159526949","https://openalex.org/W2162734772","https://openalex.org/W2162855805","https://openalex.org/W2163485494","https://openalex.org/W2164683872","https://openalex.org/W2167435540","https://openalex.org/W2168602111","https://openalex.org/W2170074416","https://openalex.org/W2170107868","https://openalex.org/W2171230529","https://openalex.org/W2474601281","https://openalex.org/W7099918793"],"related_works":["https://openalex.org/W2133757162","https://openalex.org/W1999939420","https://openalex.org/W1973676791","https://openalex.org/W2014845588","https://openalex.org/W2045031047","https://openalex.org/W2110304357","https://openalex.org/W2061850377","https://openalex.org/W1992696908","https://openalex.org/W7095258751","https://openalex.org/W2102591626"],"abstract_inverted_index":{"This":[0],"thesis":[1,28,37],"was":[2],"presented":[3],"by":[4,318,342,426],"Aaron":[5],"Webber":[6],"on":[7,348],"the":[8,14,21,52,68,129,218,223,239,253,275,285,294,299,312,329,349,358,387,393,407,450,461],"4":[9],"th":[10],"December":[11],"2013":[12],"for":[13,474],"degree":[15],"of":[16,18,23,26,32,61,76,80,112,134,165,181,188,260,277,314,351,360,440,463],"Doctor":[17],"Philosophy":[19],"from":[20,56,196,364],"University":[22],"Manchester.The":[24],"title":[25],"this":[27],"is":[29,117,159,241,307],"'Transcriptional":[30],"co-regulation":[31],"microRNAs":[33,182,208,257],"and":[34,45,87,124,127,132,153,233,332,368,409,420,430,447,466],"protein-coding":[35,123,150,167,175,189,203,225],"genes'.The":[36],"relates":[38,282],"to":[39,73,107,119,128,212,244,284,309,345,400,416,460],"gene":[40,136,151,315],"expression":[41,130,289,316,353,402,418],"regulation":[42,158],"within":[43,67,104,357],"humans":[44],"closely":[46],"related":[47,118],"primate":[48],"species.We":[49],"have":[50],"investigated":[51],"binding":[53,114],"site":[54,115],"distributions":[55],"publically":[57],"available":[58],"ChIP-seq":[59,113],"data":[60,116,254],"117":[62],"transcription":[63],"regulatory":[64,214,280,335],"factors":[65],"(TRFs)":[66],"human":[69,139,291],"genome.These":[70],"were":[71,404],"mapped":[72],"cis-regulatory":[74],"regions":[75,103],"two":[77,427],"major":[78],"classes":[79],"genes,":[81,126],"\uf0bb":[82,88],"20,000":[83],"genes":[84,90,144,176,190,266,346],"encoding":[85,91],"proteins":[86,173],"1500":[89],"microRNAs.MicroRNAs":[92],"are":[93,145,183,209,449],"short":[94],"20":[95],"-24":[96],"nt":[97],"noncoding":[98],"RNAs":[99],"which":[100],"bind":[101],"complementary":[102],"target":[105,263],"mRNAs":[106,297],"repress":[108],"translation.The":[109],"complete":[110],"collection":[111],"genomic":[120],"associations":[121],"between":[122,328],"microRNA":[125,143,178,232],"patterns":[131,354],"functions":[133],"both":[135,464],"types":[137],"across":[138,290],"tissues.We":[140],"show":[141,154,205,228,255],"that":[142,156,185,206,229,256,274,444],"associated":[146],"with":[147,201,217,269,293,372,470],"highly":[148],"regulated":[149],"regions,":[152],"rigorously":[155],"transcriptional":[157,219,330,339,414],"greater":[160],"than":[161],"expected,":[162],"given":[163],"properties":[164],"these":[166,270,344,417],"genes.We":[168],"find":[169],"enrichment":[170,302],"in":[171,222,250,267,287,303,390],"developmental":[172],"among":[174],"hosting":[177],"sequences.Novel":[179],"subclasses":[180],"identified":[184,405],"lie":[186],"outside":[187],"yet":[191,423],"may":[192],"still":[193],"be":[194],"expressed":[195],"a":[197,231,234,248,380],"shared":[198],"promoter":[199,226],"region":[200],"their":[202,352],"neighbours.We":[204],"such":[207,278,304],"more":[210,242],"likely":[211,243],"form":[213],"feedback":[215],"loops":[216],"regulators":[220,340,415],"lying":[221,258],"upstream":[224],"region.We":[227],"when":[230],"TRF":[235,240,331],"regulate":[236],"one":[237],"another,":[238],"sometimes":[245],"function":[246],"as":[247],"repressor.As":[249],"many":[251,265],"studies,":[252],"downstream":[259],"particular":[261],"TRFs":[262],"significantly":[264],"common":[268],"TRFs.We":[271],"then":[272],"demonstrate":[273,421,443],"prevalence":[276],"TRF/microRNA":[279],"partnerships":[281],"directly":[283],"variation":[286,317],"mRNA":[288],"tissues,":[292],"least":[295],"variable":[296],"having":[298],"most":[300,451],"significant":[301,325,422],"partnerships.This":[305],"result":[306],"connected":[308],"theory":[310],"describing":[311],"buffering":[313],"microRNAs.Taken":[319],"together,":[320],"our":[321],"study":[322],"has":[323],"demonstrated":[324],"novel":[326],"linkages":[327],"post-transcriptional":[333],"microRNA-mediated":[334],"layers.We":[336],"finally":[337],"consider":[338],"alone,":[341],"mapping":[343],"clustered":[347],"basis":[350],"through":[355],"time,":[356],"context":[359],"CD4+":[361],"T":[362],"cells":[363],"African":[365],"green":[366,377],"monkeys":[367,378],"Rhesus":[369],"macaques":[370],"infected":[371],"Simian":[373],"immunodeficiency":[374],"virus":[375],"(SIV).African":[376],"maintain":[379],"functioning":[381],"immune":[382,394],"system":[383,395],"despite":[384],"never":[385],"clearing":[386],"virus,":[388],"while":[389],"rhesus":[391],"macaques,":[392],"becomes":[396],"chronically":[397],"stimulated":[398],"leading":[399],"pathogenesis.Gene":[401],"clusters":[403,419],"characterizing":[406],"natural":[408,465],"pathogenic":[410,467],"host":[411],"systems.We":[412],"map":[413],"unexpected":[424],"co-binding":[425],"heterodimers":[428],"(STAT1:STAT2":[429],"BATF:IRF4)":[431],"over":[432],"key":[433],"viral":[434],"response":[435],"genes.From":[436],"34":[437],"structural":[438],"families":[439],"TRFs,":[441],"we":[442],"bZIPs,":[445],"STATs":[446],"IRFs":[448],"frequently":[452],"perturbed":[453],"upon":[454],"SIV":[455,468],"infection.Our":[456],"work":[457],"therefore":[458],"contributes":[459],"characterization":[462],"infections,":[469],"longer":[471],"term":[472],"implications":[473],"HIV":[475],"therapeutics.":[476]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}