{"id":"https://openalex.org/W2321945384","doi":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","title":"Importance of chloride for the correction of chronic metabolic alkalosis in the rat","display_name":"Importance of chloride for the correction of chronic metabolic alkalosis in the rat","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2321945384","doi":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","mag":"2321945384","pmid":"https://pubmed.ncbi.nlm.nih.gov/3688234"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.1987.253.5.f1031","doi":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113963308","display_name":"Barry M. Wall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. M. Wall","raw_affiliation_strings":["Nephrology Research and Training Center, University of Alabama atBirmingham 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Research and Training Center, University of Alabama atBirmingham 35294","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019798313","display_name":"G. V. Byrum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. V. Byrum","raw_affiliation_strings":["Nephrology Research and Training Center, University of Alabama atBirmingham 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Research and Training Center, University of Alabama atBirmingham 35294","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110849292","display_name":"John H. Galla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. H. Galla","raw_affiliation_strings":["Nephrology Research and Training Center, University of Alabama atBirmingham 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Research and Training Center, University of Alabama atBirmingham 35294","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039784082","display_name":"Robert G. Luke","orcid":"https://orcid.org/0000-0002-4930-8351","observed_orcids":["https://orcid.org/0000-0002-4930-8351"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. G. Luke","raw_affiliation_strings":["Nephrology Research and Training Center, University of Alabama atBirmingham 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Research and Training Center, University of Alabama atBirmingham 35294","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1974,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75976563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"253","issue":"5","first_page":"F1031","last_page":"F1039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloride-depletion","display_name":"chloride depletion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/choline-chloride","display_name":"choline chloride","score":0.9649999737739563},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.7429999709129333},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9610000252723694},{"id":"https://openalex.org/keywords/volume-contraction","display_name":"volume contraction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.5580000281333923},{"id":"https://openalex.org/keywords/potassium-balance","display_name":"potassium balance","score":0.6899999976158142},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/plasma-volume","display_name":"plasma volume","score":0.49000000953674316},{"id":"https://openalex.org/keywords/renin-aldosterone-system","display_name":"renin-aldosterone system","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8098267316818237},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7212545871734619},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7093833684921265},{"id":"https://openalex.org/C2779539245","wikidata":"https://www.wikidata.org/wiki/Q1428362","display_name":"Metabolic alkalosis","level":2,"score":0.677379846572876},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.6707251667976379},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.6530530452728271},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.6510095596313477},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.5949323773384094},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.5467036366462708},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.515575110912323},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.4546050429344177},{"id":"https://openalex.org/C2777068682","wikidata":"https://www.wikidata.org/wiki/Q512654","display_name":"Alkalosis","level":3,"score":0.4490705728530884},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.4463575482368469},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.2036716639995575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1610375940799713},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.14878416061401367},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.1432403326034546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13331744074821472},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000471","descriptor_name":"Alkalosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.1987.253.5.f1031","doi":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.1987.253.5.f1031","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:3688234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3688234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.952.6841","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.952.6841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajprenal.physiology.org/content/ajprenal/253/5/F1031.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1455276782","display_name":"STUDIES OF RENAL CHLORIDE TRANSPORT","funder_award_id":"5r01am026698-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3380058240","display_name":"UAB NRTC PROGRAM IN RENAL PHYSIOLOGY &DISEASE","funder_award_id":"5t32am007427-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1984431866","https://openalex.org/W2007796298","https://openalex.org/W2027787052","https://openalex.org/W2031495307","https://openalex.org/W2042403734","https://openalex.org/W2046379164","https://openalex.org/W2078194568","https://openalex.org/W2130097189","https://openalex.org/W2221150482","https://openalex.org/W2235069840","https://openalex.org/W2315868039","https://openalex.org/W2336635005","https://openalex.org/W2345174784","https://openalex.org/W2416165468","https://openalex.org/W2461993017"],"related_works":["https://openalex.org/W2043619695","https://openalex.org/W2011435721","https://openalex.org/W2085314153","https://openalex.org/W2315868039","https://openalex.org/W2428399888","https://openalex.org/W2146331933","https://openalex.org/W2426197791","https://openalex.org/W2409944062","https://openalex.org/W2091989174","https://openalex.org/W2964844564"],"abstract_inverted_index":{"To":[0],"determine":[1],"whether":[2],"chloride":[3,10,174],"repletion":[4],"without":[5,18,22],"sodium":[6,50,179],"could":[7],"correct":[8],"chronic":[9,65,163],"depletion":[11],"metabolic":[12,74],"alkalosis":[13,75],"(CDA)":[14],"in":[15],"Sprague-Dawley":[16],"rats":[17],"volume":[19,90,93,189,192],"expansion":[20],"and":[21,39,51,176,187,205],"increasing":[23],"glomerular":[24],"filtration":[25],"rate":[26],"(GFR),":[27],"CDA":[28,164],"was":[29,70,165],"generated":[30],"by":[31,44,72,167],"peritoneal":[32],"dialysis":[33],"(PD)":[34],"against":[35,58],"0.15":[36],"M":[37],"NaHCO3":[38],"maintained":[40],"for":[41],"7-10":[42],"days":[43],"a":[45],"chloride-restricted":[46],"diet":[47],"supplemented":[48],"with":[49,68],"potassium":[52,182],"salts.":[53],"Control":[54],"animals":[55],"were":[56],"dialyzed":[57],"Ringer":[59],"bicarbonate.":[60],"The":[61],"maintenance":[62],"period":[63],"of":[64,162,170,172,260],"CDA,":[66],"compared":[67],"control,":[69],"characterized":[71],"hypokalemic":[73],"(serum":[76],"TCO2":[77],"31.9":[78],"+/-":[79,83,95,99,112,116,132,136,150,154,194,198,214,218,231,235,248,252],"0.6":[80],"vs.":[81,97,114,134,152,196,216,233,250],"23.1":[82],"0.5":[84],"meq/l,":[85],"P":[86,105,122,139,157,207,224,238,255],"less":[87,106,123,140,225,239],"than":[88,107,124,141,226,240],"0.05),":[89,108,125,142,227,241],"contraction":[91,190],"(plasma":[92,191],"3.76":[94,193],"0.08":[96,195],"4.19":[98],"0.22":[100],"ml/100":[101,200],"g":[102,119,201,221],"body":[103,120,202,222],"wt,":[104],"decreased":[109,212,229],"GFR":[110,210],"(838":[111],"84":[113],"1045":[115],"45":[117,219],"microliters.min-1.100":[118,220],"wt-1,":[121,223],"increased":[126],"plasma":[127,145],"renin":[128],"activity":[129],"(PRA)":[130],"(63":[131,230],"13":[133,232],"12":[135],"3":[137],"ng.ml-1.h-1,":[138,237],"but":[143,242],"unchanged":[144],"aldosterone":[146],"concentrations":[147],"(PAC)":[148],"(4.1":[149,247],"1.0":[151,249],"3.4":[153],"1.6":[155,253],"ng/dl,":[156,254],"=":[158,208,256],"NS).":[159],"Complete":[160],"correction":[161,259],"accomplished":[166],"24":[168],"h":[169],"ingestion":[171],"choline":[173],"drink,":[175],"despite":[177],"negative":[178],"balance,":[180,183],"neutral":[181],"continued":[184],"bicarbonate":[185],"ingestion,":[186],"persistent":[188],"3.73":[197],"0.12":[199],"wt":[203],"pre-":[204],"postcorrection,":[206],"NS),":[209],"remained":[211],"(659":[213],"87":[215],"1,045":[217],"PRA":[228],"33":[234],"5":[236],"PAC":[243],"did":[244],"not":[245],"change":[246],"6.1":[251],"NS)":[257],"after":[258],"CDA.(ABSTRACT":[261],"TRUNCATED":[262],"AT":[263],"250":[264],"WORDS)":[265]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
