{"id":"https://openalex.org/W2321902518","doi":"https://doi.org/10.1158/1538-7445.am2013-4024","title":"Abstract 4024: Ten degrees of separation: novel genes affecting outcome in ovarian cancer.","display_name":"Abstract 4024: Ten degrees of separation: novel genes affecting outcome in ovarian cancer.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2321902518","doi":"https://doi.org/10.1158/1538-7445.am2013-4024","mag":"2321902518"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-4024","doi":"https://doi.org/10.1158/1538-7445.am2013-4024","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4024","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105369415","display_name":"Behrouz Zand","orcid":"https://orcid.org/0000-0002-8327-3535","observed_orcids":["https://orcid.org/0000-0002-8327-3535"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behrouz Zand","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082498438","display_name":"Cristina Ivan","orcid":"https://orcid.org/0000-0002-4848-0168","observed_orcids":["https://orcid.org/0000-0002-4848-0168"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ivan","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017773172","display_name":"Chad Victor Pecot","orcid":"https://orcid.org/0000-0002-5250-2999","observed_orcids":["https://orcid.org/0000-0002-5250-2999"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad V. Pecot","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052973096","display_name":"Rajesha Rupaimoole","orcid":"https://orcid.org/0000-0002-4795-7921","observed_orcids":["https://orcid.org/0000-0002-4795-7921"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesha Rupaimoole","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103775706","display_name":"Heather J. Dalton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather J. Dalton","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015034565","display_name":"Justin N. Bottsford-Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Bottsford-Miller","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009043320","display_name":"Wei Hu","orcid":"https://orcid.org/0000-0002-6796-8046","observed_orcids":["https://orcid.org/0000-0002-6796-8046"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Hu","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054033791","display_name":"Alpa Manchandia Nick","orcid":"https://orcid.org/0000-0001-9232-1458","observed_orcids":["https://orcid.org/0000-0001-9232-1458"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alpa M. Nick","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":["The University of Texas-M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas-M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"4024","last_page":"4024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8019999861717224},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.7419999837875366},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/slc6a1","display_name":"SLC6A1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gat1","display_name":"GABA transporter 1","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase-phosphatase","display_name":"pyruvate dehydrogenase phosphatase","score":0.890999972820282},{"id":"https://openalex.org/keywords/ehbp1","display_name":"EHBP1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pex3","display_name":"PEX3","score":0.7950000166893005},{"id":"https://openalex.org/keywords/slc22a3","display_name":"SLC22A3","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6074494123458862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5727330446243286},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.5543639659881592},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5383250713348389},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.4649082124233246},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4539480209350586},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40974774956703186},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39425358176231384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3812991976737976},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34226083755493164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30121952295303345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25047749280929565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09675902128219604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-4024","doi":"https://doi.org/10.1158/1538-7445.am2013-4024","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-4024","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2891651298","https://openalex.org/W1985530449","https://openalex.org/W3029272205","https://openalex.org/W3081537514","https://openalex.org/W2285022541","https://openalex.org/W4242227964","https://openalex.org/W4387966682","https://openalex.org/W7125699365","https://openalex.org/W2887221873","https://openalex.org/W2050551887"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"To":[2,331],"identify":[3,60],"genomic":[4],"predictors":[5],"of":[6,9,29,33,82,135,164,186,201,215,233,261,302,306,310,392,453,465,470],"overall":[7,21,367,409],"survival":[8,22,101,275,369,410],"women":[10],"with":[11,43,63,79,99,109,271],"high":[12,34,64,110,188,216,249,266,395],"grade":[13,35,396],"serous":[14,36,397],"ovarian":[15,38,398,412,460],"cancer":[16,39],"based":[17],"on":[18],"best":[19],"separation":[20],"Kaplan-Meier":[23,100],"curves":[24,102],"Methods:":[25],"Comprehensive":[26],"data":[27,52,346],"analysis":[28],"the":[30,68,83,114,165,187,202,242,303,307,311,319,329,344,466,471],"TCGA":[31,345],"dataset":[32],"epithelial":[37],"was":[40,56,146,268],"carried":[41],"out":[42],"a":[44],"\u201ctraining\u201d":[45],"(n=":[46,50],"375)":[47],"and":[48,91,131,181,237,250,280,286,352,363,386,403,413,423],"\u201cvalidation\u201d":[49],"188)":[51],"sets.":[53],"The":[54,75,106,133,143,183,198,211],"R-code":[55],"written":[57],"specifically":[58],"to":[59,96,141,159,195,264,326,365,407],"all":[61],"genes":[62,108,167,456],"expression":[65,111,190,205,221,260,267,402],"that":[66,112,154,299],"gave":[67],"greatest":[69,243],"predictive":[70,168,391],"potential":[71],"for":[72,89,103,147,151,169,295,347,474],"patient":[73],"survival.":[74],"top":[76],"ten":[77,107],"cases":[78],"lowest":[80,144],"sums":[81],"log":[84],"rank":[85],"test":[86],"p-values":[87,116],"obtained":[88],"training":[90,285],"validation":[92,287],"sets":[93,288],"were":[94],"chosen":[95],"be":[97],"included":[98],"analysis.":[104],"Results:":[105],"had":[113,241],"smallest":[115],"in":[117,175,230,245,283,318,328,338,359,381,394,411,459],"their":[118],"respective":[119],"order":[120],"were:":[121],"SLC6A1,":[122,148],"LIPK,":[123,178],"EHBP1,":[124],"SUSD5,":[125],"PEX3,":[126,180],"SLC22A3,":[127],"RABGEF1,":[128],"PPM2C,":[129,179],"KIAA1219,":[130],"GALNT10.":[132,182],"range":[134],"p-value":[136,145],"sum":[137],"ranged":[138,192,207,223],"from":[139,157,193,208,224,324],"1.77E-3":[140],"2.09E-3.":[142],"which":[149],"encodes":[150,294],"GABA":[152,156],"Transporter-1":[153],"removes":[155],"extracellular":[158],"intracellular":[160],"space.":[161],"Interestingly,":[162],"four":[163],"10":[166],"poor":[170],"outcome":[171,393,458],"are":[172,336,389],"directly":[173],"involved":[174,229,380],"cell":[176,382],"metabolism:":[177],"median":[184,199,212,246],"OS":[185,200,213,247],"gene":[189,204,217,220,404],"group":[191,206],"38":[194],"48":[196],"months.":[197,210,226],"low":[203,219,251,259],"55-70":[209],"difference":[214,244],"vs.":[218,277,290,372],"groups":[222],"15-25":[225],"EHBP1":[227],"gene,":[228],"endocytic":[231,387],"trafficking":[232,388],"transferrin":[234],"into":[235,239],"endosomes":[236],"GLUT4":[238],"adipocytes,":[240],"between":[248],"expressions":[252],"at":[253],"25":[254],"months":[255,371],"(p=":[256],"2.16E-3).":[257],"Finally,":[258],"PPM2C":[262,293,354,401],"compared":[263],"its":[265],"significantly":[269],"associated":[270],">":[272],"5":[273],"year":[274],"(10.1%":[276],"1.1%,":[278],"p=0.001)":[279],"no":[281],"recurrence":[282],"both":[284],"(12.5%":[289],"2.2%,":[291],"p=0.04).":[292],"pyruvate":[296,312,323],"dehydrogenase-phosphatase":[297],"1":[298],"catalyzes":[300],"reactivation":[301],"alpha":[304],"subunit":[305],"E1":[308],"component":[309],"dehydrogenase":[313,316],"complex.":[314],"Pyruvate":[315],"complex":[317],"active":[320],"form":[321],"transforms":[322],"glycolysis":[325],"acetyl-CoA":[327],"mitochondria.":[330],"evaluate":[332],"whether":[333],"similar":[334],"findings":[335],"noted":[337],"other":[339],"cancers,":[340],"we":[341],"also":[342],"examined":[343],"breast,":[348],"lung,":[349],"colon":[350],"cancer,":[351,362,416],"glioblastoma.":[353],"is":[355],"amplified":[356],"by":[357],"7%":[358],"invasive":[360,414],"breast":[361,415],"leads":[364,406],"an":[366],"worse":[368],"(68.9":[370],"129.5":[373],"months,":[374],"p":[375],"=":[376],"0.037).":[377],"Conclusion:":[378],"Genes":[379],"metabolism,":[383],"neurotransmitter":[384],"functioning,":[385],"highly":[390],"cancer.":[399,461],"High":[400],"amplification":[405],"worsening":[408],"respectively.":[417],"These":[418],"pathways":[419],"likely":[420],"reflect":[421],"novel":[422,455],"important":[424],"therapeutic":[425],"targets.":[426],"Citation":[427],"Format:":[428],"Behrouz":[429],"Zand,":[430],"Cristina":[431],"Ivan,":[432],"Chad":[433],"V.":[434],"Pecot,":[435],"Rajesha":[436],"Rupaimoole,":[437],"Heather":[438],"J.":[439],"Dalton,":[440],"Justin":[441],"Bottsford-Miller,":[442],"Wei":[443],"Hu,":[444],"Alpa":[445],"M.":[446],"Nick,":[447],"Anil":[448],"K.":[449],"Sood.":[450],"Ten":[451],"degrees":[452],"separation:":[454],"affecting":[457],"[abstract].":[462],"In:":[463],"Proceedings":[464],"104th":[467],"Annual":[468],"Meeting":[469],"American":[472],"Association":[473],"Cancer":[475,485],"Research;":[476],"2013":[477],"Apr":[478],"6-10;":[479],"Washington,":[480],"DC.":[481],"Philadelphia":[482],"(PA):":[483],"AACR;":[484],"Res":[486],"2013;73(8":[487],"Suppl):Abstract":[488],"nr":[489],"4024.":[490],"doi:10.1158/1538-7445.AM2013-4024":[491]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
