{"id":"https://openalex.org/W2321869799","doi":"https://doi.org/10.1177/095632020301400102","title":"Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation","display_name":"Ribavirin Derivatives with a Hexitol Moiety: Synthesis and Antiviral Evaluation","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2321869799","doi":"https://doi.org/10.1177/095632020301400102","mag":"2321869799","pmid":"https://pubmed.ncbi.nlm.nih.gov/12790513"},"language":"en","primary_location":{"id":"doi:10.1177/095632020301400102","doi":"https://doi.org/10.1177/095632020301400102","is_oa":true,"landing_page_url":"https://doi.org/10.1177/095632020301400102","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/095632020301400102","source":{"id":"https://openalex.org/S201936961","display_name":"Antiviral chemistry & chemotherapy","issn_l":"0956-3202","issn":["0956-3202","2040-2066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Chemistry and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/095632020301400102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055955896","display_name":"Arthur A. Van Aerschot","orcid":"https://orcid.org/0000-0003-3528-8588","observed_orcids":["https://orcid.org/0000-0003-3528-8588"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Arthur Van Aerschot","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025425346","display_name":"Guy Schepers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Schepers","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040404474","display_name":"Roger H. Busson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Roger Busson","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056154663","display_name":"Jef Rozenski","orcid":"https://orcid.org/0000-0001-9624-5536","observed_orcids":["https://orcid.org/0000-0001-9624-5536"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jef Rozenski","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020989565","display_name":"Piet A. Herdewijn","orcid":"https://orcid.org/0000-0003-3589-8503","observed_orcids":["https://orcid.org/0000-0003-3589-8503"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Piet Herdewijn","raw_affiliation_strings":["Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Chemistry, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.26950028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"23","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bovine-viral-diarrhea-virus","display_name":"bovine viral diarrhea virus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/yellow-fever-virus","display_name":"yellow fever virus","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chemical-synthesis","display_name":"chemical synthesis","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9564552307128906},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7305631041526794},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6302887797355652},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.532718300819397},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.5246755480766296},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5184862017631531},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4966796040534973},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.4651203155517578},{"id":"https://openalex.org/C2776844798","wikidata":"https://www.wikidata.org/wiki/Q34402","display_name":"Ribonucleoside","level":4,"score":0.46326401829719543},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4513690173625946},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.4441159665584564},{"id":"https://openalex.org/C2777343345","wikidata":"https://www.wikidata.org/wiki/Q2302993","display_name":"Sindbis virus","level":4,"score":0.44146794080734253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43059366941452026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24543261528015137},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22000300884246826},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12379831075668335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09876707196235657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001908","descriptor_name":"Diarrhea Viruses, Bovine Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001908","descriptor_name":"Diarrhea Viruses, Bovine Viral","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013402","descriptor_name":"Sugar Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/095632020301400102","doi":"https://doi.org/10.1177/095632020301400102","is_oa":true,"landing_page_url":"https://doi.org/10.1177/095632020301400102","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/095632020301400102","source":{"id":"https://openalex.org/S201936961","display_name":"Antiviral chemistry & chemotherapy","issn_l":"0956-3202","issn":["0956-3202","2040-2066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Chemistry and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:12790513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12790513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral chemistry & chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/20343","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/20343","pdf_url":"https://lirias.kuleuven.be/retrieve/a277171f-7745-488f-a4bd-4b1dfe50b71c","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antiviral Chemistry & Chemotherapy, vol. 14 (1), (23-30)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1177/095632020301400102","doi":"https://doi.org/10.1177/095632020301400102","is_oa":true,"landing_page_url":"https://doi.org/10.1177/095632020301400102","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/095632020301400102","source":{"id":"https://openalex.org/S201936961","display_name":"Antiviral chemistry & chemotherapy","issn_l":"0956-3202","issn":["0956-3202","2040-2066"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Chemistry and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321869799.pdf","grobid_xml":"https://content.openalex.org/works/W2321869799.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2545228","https://openalex.org/W90061990","https://openalex.org/W1515293536","https://openalex.org/W1539101560","https://openalex.org/W1986573884","https://openalex.org/W2040070607","https://openalex.org/W2058320288","https://openalex.org/W2063824721","https://openalex.org/W2070458768","https://openalex.org/W2090707688","https://openalex.org/W2098554674","https://openalex.org/W2166633925","https://openalex.org/W2313653714","https://openalex.org/W2399234325","https://openalex.org/W2474226276"],"related_works":["https://openalex.org/W2951086501","https://openalex.org/W4281870135","https://openalex.org/W2151492997","https://openalex.org/W1966214871","https://openalex.org/W7209360273","https://openalex.org/W1993671724","https://openalex.org/W4242476521","https://openalex.org/W2463056373","https://openalex.org/W4392225385","https://openalex.org/W2104951372"],"abstract_inverted_index":{"Current":[0],"standard":[1],"therapy":[2,16],"for":[3,98],"the":[4,31,56,72,103],"treatment":[5],"of":[6,14,60,67,71],"chronic":[7],"infections":[8],"with":[9,17,41,55],"hepatitis":[10,99],"C":[11,100],"virus":[12,85,95],"consists":[13],"combination":[15],"(pegylated)":[18],"interferon-alpha":[19],"and":[20,88],"ribavirin.":[21],"1,5-Anhydrohexitol":[22],"nucleoside":[23],"analogues":[24,38],"are":[25,39],"constrained":[26],"congeners":[27],"known":[28],"to":[29],"mimic":[30],"ribonucleoside":[32],"conformation.":[33],"Within":[34],"this":[35],"series":[36,66],"some":[37],"endowed":[40],"strong":[42],"antiviral":[43,79],"properties,":[44],"particularly":[45],"against":[46,82,91],"herpesviruses.":[47],"The":[48],"six-membered":[49],"anhydrohexitol":[50],"ring":[51],"was,":[52],"therefore,":[53],"combined":[54],"triazolyl":[57],"carboxamide":[58],"moiety":[59],"ribavirin,":[61],"thus":[62],"providing":[63],"a":[64],"new":[65],"ribavirin":[68],"analogues.":[69],"None":[70],"newly":[73],"synthesized":[74],"compounds":[75],"elicited":[76],"any":[77],"substantial":[78],"activity,":[80],"neither":[81],"herpes":[83],"simplex":[84],"type":[86],"1":[87],"2,":[89],"nor":[90],"bovine":[92],"viral":[93],"diarrhoea":[94],"(a":[96],"surrogate":[97],"virus)":[101],"or":[102],"yellow":[104],"fever":[105],"virus.":[106]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}