{"id":"https://openalex.org/W2321833802","doi":"https://doi.org/10.1161/hyp.64.suppl_1.454","title":"Abstract 454: Plgf Mediates A Neuroimmune Interaction In The Spleen To Allow The Onset Of Hypertension","display_name":"Abstract 454: Plgf Mediates A Neuroimmune Interaction In The Spleen To Allow The Onset Of Hypertension","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2321833802","doi":"https://doi.org/10.1161/hyp.64.suppl_1.454","mag":"2321833802"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.64.suppl_1.454","doi":"https://doi.org/10.1161/hyp.64.suppl_1.454","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.64.suppl_1.454","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068645306","display_name":"Daniela Carnevale","orcid":"https://orcid.org/0000-0002-5016-3161","observed_orcids":["https://orcid.org/0000-0002-5016-3161"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Carnevale","raw_affiliation_strings":["Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy","Daniela Carnevale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Daniela Carnevale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075864333","display_name":"Fabio Pallante","orcid":"https://orcid.org/0000-0001-9224-6267","observed_orcids":["https://orcid.org/0000-0001-9224-6267"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Pallante","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli (IS), Italy","Fabio Pallante"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Fabio Pallante","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035638424","display_name":"Valentina Fardella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Fardella","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli (IS), Italy","Valentina Fardella"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Valentina Fardella","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079511166","display_name":"Massimiliano De Lucia","orcid":"https://orcid.org/0000-0002-3320-9324","observed_orcids":["https://orcid.org/0000-0002-3320-9324"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimiliano De Lucia","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli (IS), Italy","Massimiliano De Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Massimiliano De Lucia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062807197","display_name":"Stefania Fardella","orcid":"https://orcid.org/0000-0002-1448-2165","observed_orcids":["https://orcid.org/0000-0002-1448-2165"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Fardella","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli (IS), Italy","Stefania Fardella"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Stefania Fardella","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090777618","display_name":"Roberta Iacobucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Iacobucci","raw_affiliation_strings":["IRCCS Neuromed, Pozzilli (IS), Italy","Roberta Iacobucci"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129"]},{"raw_affiliation_string":"Roberta Iacobucci","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027985482","display_name":"Giuseppe Lembo","orcid":"https://orcid.org/0000-0002-3510-223X","observed_orcids":["https://orcid.org/0000-0002-3510-223X"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Lembo","raw_affiliation_strings":["Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy","Giuseppe Lembo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapienza Univ of Rome at IRCCS Neuromed, Pozzilli (IS), Italy","institution_ids":["https://openalex.org/I3018288129","https://openalex.org/I861853513"]},{"raw_affiliation_string":"Giuseppe Lembo","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":0.9549999833106995},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.9409999847412109},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.8500000238418579},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/celiac-ganglion","display_name":"celiac ganglion","score":0.9300000071525574},{"id":"https://openalex.org/keywords/noradrenergic-signaling","display_name":"noradrenergic signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/timp-3","display_name":"TIMP-3","score":0.9490000009536743},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cd86-costimulation","display_name":"CD86 costimulation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.803917646408081},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7840900421142578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5529228448867798},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5511639714241028},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5175575613975525},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4678436517715454},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3320552706718445},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2093583643436432}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.64.suppl_1.454","doi":"https://doi.org/10.1161/hyp.64.suppl_1.454","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.64.suppl_1.454","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020222860","https://openalex.org/W2238893235","https://openalex.org/W2897102248","https://openalex.org/W2587790496","https://openalex.org/W4389944892","https://openalex.org/W4246070880","https://openalex.org/W4415262330","https://openalex.org/W2971613481","https://openalex.org/W3195319189","https://openalex.org/W2730038101"],"abstract_inverted_index":{"In":[0,261],"the":[1,11,109,121,135,175,188,196,200,219,224,238,247,253,267,285,310,331,335,350],"past":[2],"several":[3],"years,":[4],"there":[5],"has":[6],"been":[7],"mounting":[8],"interest":[9],"in":[10,16,93,137,223,246,264,323,334],"roles":[12],"played":[13],"by":[14,74,85,187,214,274,294],"immunity":[15,35],"hypertension,":[17,41,181],"an":[18,68],"health":[19],"problem":[20],"affecting":[21],"over":[22],"1":[23],"billion":[24],"people":[25],"worldwide.":[26],"An":[27,191],"emerging":[28],"area":[29],"of":[30,40,45,123,134,195,221,252,256,312,352],"investigation":[31],"revealed":[32],"that":[33,162,174,218,243,299,328,344],"adaptive":[34],"is":[36,62,178,302,347],"a":[37,126,132,183,250,338],"central":[38],"player":[39],"since":[42],"mice":[43,96],"devoid":[44],"T":[46,168,306],"lymphocytes":[47],"were":[48],"protected":[49,166],"from":[50,167,235,290],"AngII-induced":[51],"hypertension.":[52,80,236,324,353],"However,":[53],"how":[54],"hypertensive":[55,82],"stimuli":[56],"like":[57],"AngII":[58,87,98,103,147,154,159,209],"can":[59],"afford":[60],"this,":[61],"still":[63],"enigmatic.":[64],"Here":[65],"we":[66,140,241,297,326],"found":[67,242],"unprecedented":[69],"splenic":[70,176],"neuroimmune":[71,193,332],"pathway":[72,301],"driven":[73],"Placental":[75],"Growth":[76],"Factor":[77],"(PlGF)":[78],"during":[79],"The":[81],"response":[83,343],"induced":[84],"chronic":[86],"infusion":[88,148],"(28days)":[89],"was":[90,130,202,231,272],"completely":[91],"prevented":[92],"PlGF":[94,101,124,157,163,177,206,222,244,281,329],"KO":[95,102,158,282],"(WT":[97,153],"140\u00b12":[99],"vs":[100,156],"103\u00b13":[104],"mmHg),":[105],"as":[106,108,292],"well":[107],"typical":[110],"end":[111],"organ":[112],"damage":[113],"and":[114,143,210,315,340,346],"immune":[115],"cells":[116,169,307],"infiltration.":[117,170],"To":[118],"determine":[119],"whether":[120],"involvement":[122],"had":[125],"causal":[127],"role":[128],"or":[129],"merely":[131],"consequence":[133],"failure":[136],"BP":[138,151],"raise,":[139],"analyzed":[141],"vessels":[142],"kidney":[144],"early":[145],"after":[146],"(3days),":[149],"before":[150],"increase":[152],"108\u00b13":[155],"105\u00b11),":[160],"finding":[161],"absence":[164],"already":[165],"We":[171],"also":[172],"uncover":[173],"essential":[179],"for":[180,349],"through":[182,259,309],"noradrenergic":[184],"drive":[185],"mediated":[186],"celiac":[189,197],"ganglion.":[190],"intact":[192],"interaction":[194,333],"ganglion":[198],"on":[199],"spleen":[201,215,225,227,248],"needed":[203],"to":[204,233,304],"have":[205],"release":[207],"upon":[208,279],"chimeric":[211],"mice,":[212],"generated":[213],"transplantation,":[216],"demonstrated":[217,298],"ablation":[220],"(KO":[226],"into":[228],"WT":[229,265],"mice)":[230],"sufficient":[232],"protect":[234],"At":[237],"molecular":[239,276],"level,":[240],"released":[245],"exerted":[249],"repression":[251],"tissue":[254],"protein":[255],"inflammation":[257],"Timp3":[258,268,286],"p53.":[260],"particular,":[262],"while":[263],"splenocytes":[266,283],"transcriptional":[269],"repressor":[270,277,287],"region":[271,288],"bound":[273],"its":[275],"p53":[278],"AngII,":[280],"showed":[284],"free":[289],"p53,":[291],"evidenced":[293],"ChIP.":[295],"Finally,":[296],"this":[300],"necessary":[303,348],"control":[305],"costimulation,":[308],"regulation":[311],"CD86":[313],"expression,":[314],"allow":[316],"their":[317],"deployment":[318],"toward":[319],"classical":[320],"organs":[321],"involved":[322],"Overall,":[325],"demonstrate":[327],"mediates":[330],"spleen,":[336],"organizing":[337],"unique":[339],"non":[341],"redundant":[342],"allows":[345],"onset":[351]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}
