{"id":"https://openalex.org/W2321809877","doi":"https://doi.org/10.2741/4191","title":"The role of BRCA1 and BRCA2 in prostate cancer","display_name":"The role of BRCA1 and BRCA2 in prostate cancer","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2321809877","doi":"https://doi.org/10.2741/4191","mag":"2321809877","pmid":"https://pubmed.ncbi.nlm.nih.gov/23747895"},"language":"en","primary_location":{"id":"doi:10.2741/4191","doi":"https://doi.org/10.2741/4191","is_oa":true,"landing_page_url":"https://doi.org/10.2741/4191","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark4191.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark4191.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024030506","display_name":"Roy A. Jensen","orcid":"https://orcid.org/0000-0003-4430-2281","observed_orcids":["https://orcid.org/0000-0003-4430-2281"]},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roy Jensen","raw_affiliation_strings":["Department of Anatomy & Cell Biology and","Department of Pathology & Laboratory Medicine,","The University of Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Cell Biology and","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology & Laboratory Medicine,","institution_ids":[]},{"raw_affiliation_string":"The University of Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160","institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024030506"],"corresponding_institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"],"apc_list":null,"apc_paid":null,"fwci":1.9198,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.86236425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"4","first_page":"1445","last_page":"1445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":1.0},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.800000011920929},{"id":"https://openalex.org/keywords/hereditary-cancer-susceptibility","display_name":"hereditary cancer predisposition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/janus-kinase","display_name":"Janus kinase","score":0.800000011920929},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.765999972820282},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5519999861717224},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8832963705062866},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6384862065315247},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6177835464477539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5831338167190552},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5587711930274963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.537416934967041},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.5017898082733154},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4983031749725342},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47707831859588623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44876667857170105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35427552461624146},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019398","descriptor_name":"Genes, BRCA1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024522","descriptor_name":"Genes, BRCA2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2741/4191","doi":"https://doi.org/10.2741/4191","is_oa":true,"landing_page_url":"https://doi.org/10.2741/4191","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark4191.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},{"id":"pmid:23747895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23747895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2741/4191","doi":"https://doi.org/10.2741/4191","is_oa":true,"landing_page_url":"https://doi.org/10.2741/4191","pdf_url":"https://article.imrpress.com/bri/Landmark/articles/pdf/Landmark4191.pdf","source":{"id":"https://openalex.org/S185455647","display_name":"Frontiers in bioscience","issn_l":"1093-4715","issn":["1093-4715","1093-9946","1094-3935"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320848","host_organization_name":"Frontiers in Bioscience","host_organization_lineage":["https://openalex.org/P4310320848"],"host_organization_lineage_names":["Frontiers in Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321809877.pdf","grobid_xml":"https://content.openalex.org/works/W2321809877.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1485457104","https://openalex.org/W1496591359","https://openalex.org/W1558623255","https://openalex.org/W1575078202","https://openalex.org/W1603850660","https://openalex.org/W1821992417","https://openalex.org/W1890551980","https://openalex.org/W1891364196","https://openalex.org/W1914602388","https://openalex.org/W1967705369","https://openalex.org/W1968068448","https://openalex.org/W1968788534","https://openalex.org/W1969603568","https://openalex.org/W1969693388","https://openalex.org/W1971708656","https://openalex.org/W1971781813","https://openalex.org/W1973767454","https://openalex.org/W1975823330","https://openalex.org/W1977546001","https://openalex.org/W1978427005","https://openalex.org/W1979368669","https://openalex.org/W1980191680","https://openalex.org/W1985529128","https://openalex.org/W1987562801","https://openalex.org/W1995328863","https://openalex.org/W1999859219","https://openalex.org/W2003291016","https://openalex.org/W2007686629","https://openalex.org/W2009454156","https://openalex.org/W2009759387","https://openalex.org/W2012523195","https://openalex.org/W2012553828","https://openalex.org/W2013708901","https://openalex.org/W2015637732","https://openalex.org/W2019431776","https://openalex.org/W2021343970","https://openalex.org/W2028733426","https://openalex.org/W2029584768","https://openalex.org/W2029878093","https://openalex.org/W2032346580","https://openalex.org/W2032605043","https://openalex.org/W2036245489","https://openalex.org/W2039211343","https://openalex.org/W2047800385","https://openalex.org/W2049007599","https://openalex.org/W2049526866","https://openalex.org/W2050252843","https://openalex.org/W2051651668","https://openalex.org/W2054605948","https://openalex.org/W2058832352","https://openalex.org/W2059061584","https://openalex.org/W2059696257","https://openalex.org/W2067821218","https://openalex.org/W2067894718","https://openalex.org/W2069589272","https://openalex.org/W2070607408","https://openalex.org/W2075417812","https://openalex.org/W2076668528","https://openalex.org/W2076699441","https://openalex.org/W2076860818","https://openalex.org/W2078343553","https://openalex.org/W2078644395","https://openalex.org/W2087963453","https://openalex.org/W2090740451","https://openalex.org/W2091961739","https://openalex.org/W2093542878","https://openalex.org/W2093760401","https://openalex.org/W2097036681","https://openalex.org/W2098436115","https://openalex.org/W2101791074","https://openalex.org/W2102892939","https://openalex.org/W2103533058","https://openalex.org/W2106736735","https://openalex.org/W2106787323","https://openalex.org/W2107482866","https://openalex.org/W2108860692","https://openalex.org/W2109465247","https://openalex.org/W2111659024","https://openalex.org/W2112211663","https://openalex.org/W2114552084","https://openalex.org/W2117503386","https://openalex.org/W2120579697","https://openalex.org/W2133485545","https://openalex.org/W2138388674","https://openalex.org/W2144465725","https://openalex.org/W2147385400","https://openalex.org/W2147755051","https://openalex.org/W2148263950","https://openalex.org/W2151379741","https://openalex.org/W2151674038","https://openalex.org/W2152161852","https://openalex.org/W2153579158","https://openalex.org/W2155769914","https://openalex.org/W2156871551","https://openalex.org/W2158725489","https://openalex.org/W2165948908","https://openalex.org/W2169438923","https://openalex.org/W2322278092","https://openalex.org/W2323083017","https://openalex.org/W2339049778","https://openalex.org/W2432399543","https://openalex.org/W2438300343","https://openalex.org/W2593526662","https://openalex.org/W2772971838"],"related_works":["https://openalex.org/W2078949257","https://openalex.org/W2059696257","https://openalex.org/W4376459526","https://openalex.org/W2028733426","https://openalex.org/W1985529128","https://openalex.org/W3211405144","https://openalex.org/W7099871832","https://openalex.org/W2076860818","https://openalex.org/W4366833142","https://openalex.org/W2098436115"],"abstract_inverted_index":{"The":[0,77],"familial":[1],"aggregation":[2],"of":[3,20,31,50,67,79,97],"prostate":[4,55,74,88,138,152,164,169],"cancer":[5,8,24,34,56,75,89,139,153,165,170],"and":[6,17,38,58,69,87,104,116,120,163,173],"breast":[7,23],"has":[9,141],"been":[10,142],"observed":[11],"for":[12,160],"almost":[13],"half":[14],"a":[15,94],"century":[16],"about":[18],"85%":[19],"the":[21,48,64,82,112],"inherited":[22],"can":[25,108,121],"be":[26,145,158],"linked":[27],"to":[28,54,144],"germ-line":[29],"mutations":[30,86],"BRCA1":[32,107],"(breast":[33],"1,":[35],"early":[36],"onset)":[37],"BRCA2.":[39],"In":[40],"this":[41],"review,":[42],"we":[43],"are":[44,90],"mainly":[45],"focusing":[46],"on":[47],"contribution":[49],"BRCA1/2":[51,68,85],"sequence":[52],"variations":[53],"risk":[57],"disease":[59],"progression.":[60,154],"We":[61],"will":[62],"discuss":[63],"biological":[65],"functions":[66],"BRCA1/2-related":[70],"signaling":[71],"pathways":[72],"in":[73,131,137,147],"biology.":[76],"majority":[78],"studies":[80],"supporting":[81],"link":[83],"between":[84],"from":[91],"populations":[92],"with":[93,111],"high":[95],"frequency":[96],"mutations,":[98],"such":[99],"as":[100],"Ashkenazi":[101],"Jewish,":[102],"Icelandic,":[103],"U.K.":[105],"population.":[106],"directly":[109],"interact":[110],"androgen":[113],"receptor":[114,128],"(AR)":[115],"Janus":[117],"kinase":[118],"(JAK),":[119],"differentially":[122],"regulate":[123],"insulin-like":[124],"growth":[125],"factor":[126],"1":[127],"(IGF-IR)":[129],"expression":[130],"an":[132],"AR-dependent":[133],"manner.":[134],"BRCA2":[135],"homeostasis":[136],"cells":[140],"found":[143],"critical":[146],"determining":[148],"cell":[149],"fates":[150],"during":[151],"This":[155],"review":[156],"may":[157],"helpful":[159],"medical":[161],"professionals":[162],"patients":[166],"when":[167],"discussing":[168],"risks,":[171],"treatment":[172],"prognosis.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
