{"id":"https://openalex.org/W2321789941","doi":null,"title":"[Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells].","display_name":"[Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells].","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2321789941","mag":"2321789941","pmid":"https://pubmed.ncbi.nlm.nih.gov/25975022"},"language":"zh","primary_location":{"id":"pmid:25975022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25975022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101781630","display_name":"Qian Wu","orcid":"https://orcid.org/0000-0003-3345-4247","observed_orcids":["https://orcid.org/0000-0003-3345-4247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387207","display_name":"Ning Wang","orcid":"https://orcid.org/0000-0003-1410-329X","observed_orcids":["https://orcid.org/0000-0003-1410-329X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100665756","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0001-7689-4942","observed_orcids":["https://orcid.org/0000-0001-7689-4942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039772567","display_name":"Guangyun Wang","orcid":"https://orcid.org/0009-0007-7431-6293","observed_orcids":["https://orcid.org/0009-0007-7431-6293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Yun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073486278","display_name":"Xinxin Piao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-Xin Piao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3078,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.5665701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"50","issue":"2","first_page":"162","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.22139999270439148,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligustilide","display_name":"ligustilide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bcl-2-bax-ratio","display_name":"Bcl-2/Bax ratio","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7778685092926025},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.7742960453033447},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6730764508247375},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6340814232826233},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5930208563804626},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5828342437744141},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5745658874511719},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.566656768321991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4566690921783447},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45406055450439453},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4295721650123596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3689226508140564},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34778738021850586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33393919467926025},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.03622931241989136},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014966","descriptor_name":"Xanthenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25975022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25975022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},{"id":"mag:2321789941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25975022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2297734698","https://openalex.org/W2976729398","https://openalex.org/W2372376750","https://openalex.org/W2057113140","https://openalex.org/W2382370900","https://openalex.org/W4392148382","https://openalex.org/W2388634501","https://openalex.org/W3083899734","https://openalex.org/W2080560598","https://openalex.org/W2066301503"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,97,135,170,178],"neuroprotective":[3],"of":[4,10,67,99,114,126,137,180],"ligustilide":[5],"(LIG)":[6],"against":[7],"glutamate-induced":[8,89,163],"apoptosis":[9,27,86,164],"PC12":[11,90,152,166],"cells,":[12],"cell":[13,26,83],"viability":[14],"were":[15,49,119],"examined":[16],"by":[17,34,51,107,117,122],"MTT":[18],"assay.":[19],"Flow":[20],"cytometry":[21],"was":[22,32,92],"applied":[23],"to":[24,185],"assay":[25],"rate.":[28],"Intracellular":[29],"calcium":[30],"concentration":[31,64],"measured":[33],"using":[35],"fluorescent":[36],"dye":[37],"Fluo-3/AM.":[38],"Cytochrome":[39],"C":[40,139,182],"(Cyt":[41],"C),":[42],"Caspase-3,":[43],"Bax":[44],"and":[45,94,146,176],"Bcl-2":[46],"protein":[47,144],"expression":[48,145],"assayed":[50],"western":[52,127],"blot.":[53],"The":[54,85,124],"results":[55,125],"showed":[56],"that":[57,130],"glutamate":[58,118],"is":[59],"cytotoxic":[60],"with":[61,73],"an":[62],"inhibitory":[63],"50":[65],"(ID50)":[66],"15":[68,77,103],"mmol":[69],"\u00b7":[70,79,105],"L(-1).":[71],"Pretreatment":[72],"LIG":[74,100,132,158],"(1,":[75,101],"5,":[76,102],"\u03bcmol":[78,104],"L(-1))":[80,106],"significantly":[81,120],"improved":[82],"viability.":[84],"rate":[87],"in":[88,96,165,172],"cells":[91,153,167],"13.39%,":[93],"decreased":[95],"presence":[98],"9.06%,":[108],"6.48%,":[109],"3.82%,":[110],"separately.":[111],"Extracellular":[112],"accumulation":[113],"Ca2+":[115,174],"induced":[116],"reduced":[121],"LIG.":[123],"blot":[128],"manifested":[129],"pretreatment":[131],"could":[133],"decrease":[134],"release":[136,179],"Cyt":[138,181],"from":[140,154,183],"mitochondria,":[141],"down-regulate":[142],"Caspase-3":[143],"up-regulate":[147],"Bcl-2/Bax":[148],"ratio,":[149],"thereby":[150],"protects":[151],"apoptosis.":[155],"In":[156],"summary,":[157],"had":[159],"protective":[160],"effect":[161],"on":[162],"through":[168],"attenuating":[169],"increase":[171],"intracellular":[173],"concentration,":[175],"inhibiting":[177],"mitochondria":[184],"cytoplasm.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
