{"id":"https://openalex.org/W2321787196","doi":"https://doi.org/10.1080/00021369.1988.10868743","title":"A Mechanism for Bitter Taste Sensibility in Peptides","display_name":"A Mechanism for Bitter Taste Sensibility in Peptides","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2321787196","doi":"https://doi.org/10.1080/00021369.1988.10868743","mag":"2321787196"},"language":"en","primary_location":{"id":"doi:10.1080/00021369.1988.10868743","doi":"https://doi.org/10.1080/00021369.1988.10868743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00021369.1988.10868743","pdf_url":null,"source":{"id":"https://openalex.org/S2764346059","display_name":"Agricultural and Biological Chemistry","issn_l":"0002-1369","issn":["0002-1369","0375-8397","1881-1272","1881-1280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural and Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bbb1961/52/3/52_3_819/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113783294","display_name":"Norio Ishibashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116533","display_name":"Morinaga (Japan)","ror":"https://ror.org/01tqja591","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210116533"]},{"id":"https://openalex.org/I4405272692","display_name":"Morinaga Milk Industry Co., Ltd. (Japan)","ror":"https://ror.org/04hy75g65","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Ishibashi","raw_affiliation_strings":["Morinaga Milk Industry Co., Ltd., Nutritional Science Laboratory, 4\u201322, Meguro 4-chome, Meguro-ku, Tokyo 153, Japan","Morinaga Milk Industry Co., Ltd., Nutritional Science Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morinaga Milk Industry Co., Ltd., Nutritional Science Laboratory, 4\u201322, Meguro 4-chome, Meguro-ku, Tokyo 153, Japan","institution_ids":["https://openalex.org/I4210116533","https://openalex.org/I4405272692"]},{"raw_affiliation_string":"Morinaga Milk Industry Co., Ltd., Nutritional Science Laboratory","institution_ids":["https://openalex.org/I4405272692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045170096","display_name":"Katsushige Kouge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsushige Kouge","raw_affiliation_strings":["Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","Department of Fermentation Technology, Faculty of Engineering, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036596689","display_name":"Ichizo Shinoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichizo Shinoda","raw_affiliation_strings":["Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","Department of Fermentation Technology, Faculty of Engineering, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056065556","display_name":"Hidenori Kanehisa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Kanehisa","raw_affiliation_strings":["Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","Department of Fermentation Technology, Faculty of Engineering, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050416527","display_name":"Hideo Okai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideo Okai","raw_affiliation_strings":["Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","Department of Fermentation Technology, Faculty of Engineering, Hiroshima University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University, Shitami, Saijo-cho, Higashihiroshima 724, Japan","institution_ids":["https://openalex.org/I113306721"]},{"raw_affiliation_string":"Department of Fermentation Technology, Faculty of Engineering, Hiroshima University","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050416527"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":null,"apc_paid":null,"fwci":0.4247,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.64072848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"52","issue":"3","first_page":"819","last_page":"827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitter-taste","display_name":"bitter taste","score":0.9459999799728394},{"id":"https://openalex.org/keywords/peptides","display_name":"peptides","score":0.5830000042915344},{"id":"https://openalex.org/keywords/diketopiperazines","display_name":"diketopiperazines","score":0.878000020980835},{"id":"https://openalex.org/keywords/bitter-taste-receptors","display_name":"bitter taste receptors","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8817636966705322},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.8810961246490479},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.7783457040786743},{"id":"https://openalex.org/C3020017864","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Bitter taste","level":3,"score":0.7629023790359497},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6314336061477661},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6281318664550781},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4448372423648834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2979850172996521}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/00021369.1988.10868743","doi":"https://doi.org/10.1080/00021369.1988.10868743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00021369.1988.10868743","pdf_url":null,"source":{"id":"https://openalex.org/S2764346059","display_name":"Agricultural and Biological Chemistry","issn_l":"0002-1369","issn":["0002-1369","0375-8397","1881-1272","1881-1280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural and Biological Chemistry","raw_type":"journal-article"},{"id":"doi:10.1271/bbb1961.52.819","doi":"https://doi.org/10.1271/bbb1961.52.819","is_oa":true,"landing_page_url":"https://doi.org/10.1271/bbb1961.52.819","pdf_url":"https://www.jstage.jst.go.jp/article/bbb1961/52/3/52_3_819/_pdf","source":{"id":"https://openalex.org/S2764346059","display_name":"Agricultural and Biological Chemistry","issn_l":"0002-1369","issn":["0002-1369","0375-8397","1881-1272","1881-1280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural and Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1271/bbb1961.52.819","doi":"https://doi.org/10.1271/bbb1961.52.819","is_oa":true,"landing_page_url":"https://doi.org/10.1271/bbb1961.52.819","pdf_url":"https://www.jstage.jst.go.jp/article/bbb1961/52/3/52_3_819/_pdf","source":{"id":"https://openalex.org/S2764346059","display_name":"Agricultural and Biological Chemistry","issn_l":"0002-1369","issn":["0002-1369","0375-8397","1881-1272","1881-1280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Agricultural and Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321787196.pdf","grobid_xml":"https://content.openalex.org/works/W2321787196.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W6608989391"],"related_works":["https://openalex.org/W2408725997","https://openalex.org/W3164391975","https://openalex.org/W2341226060","https://openalex.org/W3157436195","https://openalex.org/W3123143574","https://openalex.org/W3113380829","https://openalex.org/W2516812563","https://openalex.org/W2574758157","https://openalex.org/W2018870187","https://openalex.org/W2512320953"],"abstract_inverted_index":{"To":[0],"estimate":[1],"the":[2,6,61,73,77,88,102],"steric":[3,49],"distance":[4,50],"between":[5,51],"bitter":[7,41,74,81,89],"taste":[8,42,82,90],"determinant":[9,43,83],"sites":[10,53],"in":[11,72,104],"peptides,":[12],"some":[13],"cyclic":[14,36,65],"dipeptides,":[15],"amino":[16,19,24,70],"acid":[17,20],"anilides,":[18],"cyclohexylamides,":[21],"and":[22,28,96],"benzoyl":[23],"acids":[25,71],"were":[26,31],"synthesized":[27],"their":[29],"tastes":[30],"evaluated.The":[32],"diketopiperazine":[33],"ring":[34],"of":[35,64,68,79],"dipeptides":[37,66],"acted":[38],"as":[39,56],"a":[40,93,97,100],"site":[44],"due":[45],"to":[46,76],"its":[47],"hydrophobicity.The":[48],"2":[52],"was":[54],"estimated":[55],"4.":[57],"1":[58],"A":[59],"from":[60],"molecule":[62],"models":[63],"composed":[67],"typical":[69],"peptides.Due":[75],"hypothesis":[78],"two":[80],"sites,":[84],"which":[85],"bind":[86],"with":[87],"receptor":[91],"via":[92],"\"binding":[94],"unit\"":[95],"\"stimulating":[98],"unit,\"":[99],"mechanismfor":[101],"bitterness":[103],"peptides":[105],"waspostulated.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}