{"id":"https://openalex.org/W2321701123","doi":"https://doi.org/10.1042/bj20141319","title":"Dissecting structural and electronic effects in inducible nitric oxide synthase","display_name":"Dissecting structural and electronic effects in inducible nitric oxide synthase","publication_year":2015,"publication_date":"2015-01-23","ids":{"openalex":"https://openalex.org/W2321701123","doi":"https://doi.org/10.1042/bj20141319","mag":"2321701123","pmid":"https://pubmed.ncbi.nlm.nih.gov/25608846","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369157"},"language":"en","primary_location":{"id":"doi:10.1042/bj20141319","doi":"https://doi.org/10.1042/bj20141319","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20141319","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369157","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039505688","display_name":"Luciana Hannibal","orcid":"https://orcid.org/0000-0002-0911-5758","observed_orcids":["https://orcid.org/0000-0002-0911-5758"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Luciana Hannibal","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","Lehrstuhl f\u00fcr Bioanorganische Chemie, Department Chemie und Pharmazie, Universit\u00e4t Erlangen-N\u00fcrnberg, Egerlandstra\u00dfe 1, D-91058, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Lehrstuhl f\u00fcr Bioanorganische Chemie, Department Chemie und Pharmazie, Universit\u00e4t Erlangen-N\u00fcrnberg, Egerlandstra\u00dfe 1, D-91058, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021853695","display_name":"Richard C. Page","orcid":"https://orcid.org/0000-0002-3006-3171","observed_orcids":["https://orcid.org/0000-0002-3006-3171"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard\u00a0C. Page","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, U.S.A","Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, U.S.A","institution_ids":["https://openalex.org/I83328450"]},{"raw_affiliation_string":"Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076231663","display_name":"Mohammad Mahfuzul Haque","orcid":"https://orcid.org/0000-0003-0852-6368","observed_orcids":["https://orcid.org/0000-0003-0852-6368"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad\u00a0Mahfuzul Haque","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058029791","display_name":"Karthik Bolisetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karthik Bolisetty","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073785983","display_name":"Zhihao Yu","orcid":"https://orcid.org/0000-0002-6538-5007","observed_orcids":["https://orcid.org/0000-0002-6538-5007"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhihao Yu","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001496532","display_name":"Saurav Misra","orcid":"https://orcid.org/0000-0002-1385-8554","observed_orcids":["https://orcid.org/0000-0002-1385-8554"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saurav Misra","raw_affiliation_strings":["Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067430639","display_name":"Dennis J. Stuehr","orcid":"https://orcid.org/0000-0002-0960-6848","observed_orcids":["https://orcid.org/0000-0002-0960-6848"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis\u00a0J. Stuehr","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039505688","https://openalex.org/A5058029791","https://openalex.org/A5073785983"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I181369854","https://openalex.org/I4405287411"],"apc_list":null,"apc_paid":null,"fwci":0.547,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.65552195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"467","issue":"1","first_page":"153","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/l-arginine-oxidation","display_name":"L-arginine oxidation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/oxygen-activation","display_name":"oxygen activation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/single-turnover-kinetics","display_name":"single-turnover kinetics","score":0.531000018119812},{"id":"https://openalex.org/keywords/electronic-effects","display_name":"electronic effects","score":0.4259999990463257},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.5479999780654907},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7581425309181213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6029818058013916},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5844157338142395},{"id":"https://openalex.org/C165474305","wikidata":"https://www.wikidata.org/wiki/Q419615","display_name":"Oxygenase","level":3,"score":0.552538275718689},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5427636504173279},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5193229913711548},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.49968528747558594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46535784006118774},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3393763601779938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21477553248405457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13544175028800964},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06367269158363342}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20141319","doi":"https://doi.org/10.1042/bj20141319","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20141319","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:25608846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25608846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4369157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4369157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4369157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1934500543","display_name":null,"funder_award_id":"CA-53914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3229075327","display_name":null,"funder_award_id":"HL76491","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5516667309","display_name":"Oxidation in Inflammation and Cardiovascular Disease","funder_award_id":"P01HL076491","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5949373188","display_name":null,"funder_award_id":"GM51491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7542777358","display_name":"Control Mechanisms of the Nitric Oxide Synthases","funder_award_id":"R01GM051491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8002740394","display_name":"Training Program in Vascular Biology and Pathology","funder_award_id":"T32HL007914","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G812330103","display_name":"Biochemistry of Nitric Oxide Synthesis","funder_award_id":"R01CA053914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8441272977","display_name":"Clinical and Translational Science Collaborative of Cleveland","funder_award_id":"UL1TR000439","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1487443561","https://openalex.org/W1496069463","https://openalex.org/W1539505312","https://openalex.org/W1595536542","https://openalex.org/W1965614666","https://openalex.org/W1969000829","https://openalex.org/W1974799534","https://openalex.org/W1979061252","https://openalex.org/W1979266158","https://openalex.org/W1979424014","https://openalex.org/W1986398709","https://openalex.org/W1991667974","https://openalex.org/W1997070952","https://openalex.org/W1997874446","https://openalex.org/W2000481471","https://openalex.org/W2005280380","https://openalex.org/W2005819238","https://openalex.org/W2009685357","https://openalex.org/W2009798288","https://openalex.org/W2020667687","https://openalex.org/W2020719862","https://openalex.org/W2021389175","https://openalex.org/W2023553716","https://openalex.org/W2027003138","https://openalex.org/W2027459039","https://openalex.org/W2039279963","https://openalex.org/W2042123292","https://openalex.org/W2045639174","https://openalex.org/W2051982172","https://openalex.org/W2056420994","https://openalex.org/W2058366028","https://openalex.org/W2059177631","https://openalex.org/W2063944286","https://openalex.org/W2068777040","https://openalex.org/W2076291690","https://openalex.org/W2084893095","https://openalex.org/W2092939065","https://openalex.org/W2114622716","https://openalex.org/W2116947993","https://openalex.org/W2122339645","https://openalex.org/W2124026197","https://openalex.org/W2132012540","https://openalex.org/W2160969115","https://openalex.org/W2163341755","https://openalex.org/W2180229411","https://openalex.org/W2330496367","https://openalex.org/W2389622235"],"related_works":["https://openalex.org/W2132012540","https://openalex.org/W7096974968","https://openalex.org/W2063944286","https://openalex.org/W2160969115","https://openalex.org/W3176868378","https://openalex.org/W2065839936","https://openalex.org/W1989417904","https://openalex.org/W2063235712","https://openalex.org/W2023609802","https://openalex.org/W2040407936"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1],"synthases":[2],"(NOSs)":[3],"are":[4],"haem-thiolate":[5],"enzymes":[6],"that":[7,130,213],"catalyse":[8],"the":[9,44,49,52,77,147,164,173,184,214],"conversion":[10,138],"of":[11,25,36,51,69,79,109,136,151,166,175,186,205],"L-arginine":[12],"(L-Arg)":[13],"into":[14],"NO":[15,26,199],"and":[16,48,75,96,100,102,139,157,177],"citrulline.":[17],"Inducible":[18],"NOS":[19,153],"(iNOS)":[20],"is":[21,38,221],"responsible":[22],"for":[23,60],"delivery":[24],"in":[27,88,189,218],"response":[28],"to":[29,40,55,107],"stressors":[30],"during":[31,192],"inflammation.":[32],"The":[33,201],"catalytic":[34],"performance":[35],"iNOS":[37,71,89,167,191,220],"proposed":[39],"rely":[41],"mainly":[42],"on":[43],"haem":[45,209],"midpoint":[46],"potential":[47],"ability":[50],"substrate":[53],"L-Arg":[54,120],"provide":[56],"a":[57,67,80,152],"hydrogen":[58],"bond":[59],"oxygen":[61],"activation":[62],"(O-O":[63],"scission).":[64],"We":[65,145],"present":[66],"study":[68],"native":[70,111,169,208],"compared":[72,162],"with":[73,93,119,155,163],"iNOS-mesohaem,":[74],"investigate":[76],"formation":[78],"low-spin":[81],"ferric":[82],"haem-aquo":[83],"or":[84,124,210],"-hydroxo":[85],"species":[86,187],"(P)":[87],"mutant":[90],"W188H":[91,190],"substituted":[92,154],"mesohaem.":[94],"iNOS-mesohaem":[95],"W188H-mesohaem":[97],"were":[98],"stable":[99],"dimeric,":[101],"presented":[103],"substrate-binding":[104],"affinities":[105],"comparable":[106],"those":[108],"their":[110],"counterparts.":[112],"Single":[113],"turnover":[114],"reactions":[115],"catalysed":[116],"by":[117,225],"iNOSoxy":[118,206],"(first":[121],"reaction":[122,127],"step)":[123,128],"N-hydroxy-L-arginine":[125],"(second":[126],"showed":[129],"mesohaem":[131,156,211],"substitution":[132,181],"triggered":[133],"higher":[134],"rates":[135],"Fe(II)O\u2082":[137],"altered":[140],"other":[141],"key":[142],"kinetic":[143,215],"parameters.":[144],"elucidated":[146],"first":[148],"crystal":[149],"structure":[150,165],"found":[158],"essentially":[159],"identical":[160],"features":[161],"carrying":[168],"haem.":[170],"This":[171],"facilitated":[172],"dissection":[174],"structural":[176,203,230],"electronic":[178,226],"effects.":[179],"Mesohaem":[180],"substantially":[182],"reduced":[183],"build-up":[185],"P":[188],"catalysis,":[193],"thus":[194],"increasing":[195],"its":[196],"proficiency":[197],"towards":[198],"synthesis.":[200],"marked":[202],"similarities":[204],"containing":[207],"indicate":[212],"behaviour":[216],"observed":[217],"mesohaem-substituted":[219],"most":[222],"heavily":[223],"influenced":[224],"effects":[227],"rather":[228],"than":[229],"alterations.":[231]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
