{"id":"https://openalex.org/W2321660256","doi":"https://doi.org/10.1097/med.0b013e328013e79e","title":"Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic","display_name":"Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic","publication_year":2007,"publication_date":"2007-02-01","ids":{"openalex":"https://openalex.org/W2321660256","doi":"https://doi.org/10.1097/med.0b013e328013e79e","mag":"2321660256","pmid":"https://pubmed.ncbi.nlm.nih.gov/17940423"},"language":"en","primary_location":{"id":"doi:10.1097/med.0b013e328013e79e","doi":"https://doi.org/10.1097/med.0b013e328013e79e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0b013e328013e79e","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes & Obesity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005860942","display_name":"Benedikt A. Aulinger","orcid":"https://orcid.org/0000-0001-8292-7456","observed_orcids":["https://orcid.org/0000-0001-8292-7456"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedikt Aulinger","raw_affiliation_strings":["Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio 45267, USA","Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA","e-mail: [email\u00a0protected]","fax: +1 513 558 8581"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio 45267, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 513 558 8581","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111682450","display_name":"David D. D\u2019Alessio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David D'Alessio","raw_affiliation_strings":["Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA","to David D'Alessio, MD, Division of Endocrinology, University of Cincinnati, ML 0547, Cincinnati, OH 45267, USA Tel: +1 513 558 6689; fax: +1 513 558 8581; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 513 558 8581"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"to David D'Alessio, MD, Division of Endocrinology, University of Cincinnati, ML 0547, Cincinnati, OH 45267, USA Tel: +1 513 558 6689; fax: +1 513 558 8581; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 513 558 8581","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111682450"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.2435,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.2686109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"1","first_page":"68","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/incretin-effect","display_name":"incretin effect","score":0.7020000219345093},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.8029999732971191},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8119999766349792},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/intestinal-l-cells","display_name":"intestinal L cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.8259999752044678},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.652999997138977},{"id":"https://openalex.org/keywords/cardiac-hemodynamics","display_name":"cardiac hemodynamics","score":0.7039999961853027},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9229999780654907},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/islet-mass","display_name":"islet mass","score":0.8859999775886536},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/diabetes-treatment","display_name":"diabetes treatment","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.767409086227417},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.7157122492790222},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.6587003469467163},{"id":"https://openalex.org/C2781219945","wikidata":"https://www.wikidata.org/wiki/Q5572288","display_name":"Glucagon-like peptide-2","level":3,"score":0.6508390307426453},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5233651399612427},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4802580177783966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42006051540374756},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39346742630004883},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.37991654872894287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3655787706375122},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.33048301935195923},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2660871744155884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1285930871963501}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009747","descriptor_name":"Nutritional Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/med.0b013e328013e79e","doi":"https://doi.org/10.1097/med.0b013e328013e79e","is_oa":false,"landing_page_url":"https://doi.org/10.1097/med.0b013e328013e79e","pdf_url":null,"source":{"id":"https://openalex.org/S177297213","display_name":"Current Opinion in Endocrinology Diabetes and Obesity","issn_l":"1752-296X","issn":["1752-296X","1752-2978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Endocrinology, Diabetes & Obesity","raw_type":"journal-article"},{"id":"pmid:17940423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17940423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in endocrinology, diabetes, and obesity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1584197284","https://openalex.org/W1831731874","https://openalex.org/W1936375955","https://openalex.org/W1968315455","https://openalex.org/W1969628999","https://openalex.org/W1971244959","https://openalex.org/W1972534040","https://openalex.org/W1973109904","https://openalex.org/W1989616977","https://openalex.org/W2003380560","https://openalex.org/W2004836557","https://openalex.org/W2008501546","https://openalex.org/W2011601530","https://openalex.org/W2013082477","https://openalex.org/W2017518223","https://openalex.org/W2032322539","https://openalex.org/W2041150765","https://openalex.org/W2046239863","https://openalex.org/W2052690953","https://openalex.org/W2063400466","https://openalex.org/W2064492226","https://openalex.org/W2069279764","https://openalex.org/W2076492631","https://openalex.org/W2108363905","https://openalex.org/W2109327370","https://openalex.org/W2111320266","https://openalex.org/W2117905450","https://openalex.org/W2121497054","https://openalex.org/W2122187653","https://openalex.org/W2122464768","https://openalex.org/W2124016563","https://openalex.org/W2124831863","https://openalex.org/W2127409471","https://openalex.org/W2129546109","https://openalex.org/W2129730863","https://openalex.org/W2130083450","https://openalex.org/W2134141467","https://openalex.org/W2140839640","https://openalex.org/W2141917858","https://openalex.org/W2144343807","https://openalex.org/W2145124248","https://openalex.org/W2145519915","https://openalex.org/W2147823258","https://openalex.org/W2147883561","https://openalex.org/W2147973767","https://openalex.org/W2148479818","https://openalex.org/W2162643987","https://openalex.org/W2169976140","https://openalex.org/W2201588835","https://openalex.org/W2409053483","https://openalex.org/W4252795044","https://openalex.org/W6638641871","https://openalex.org/W6681688128"],"related_works":["https://openalex.org/W2795481136","https://openalex.org/W117182949","https://openalex.org/W2980605149","https://openalex.org/W2084808644","https://openalex.org/W2116586501","https://openalex.org/W2106036385","https://openalex.org/W1588939233","https://openalex.org/W2014732107","https://openalex.org/W2358612815","https://openalex.org/W2078115857"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"article":[4],"discusses":[5],"glucagon-like":[6,72,83,129,157,172,210],"peptide":[7,30,73,84,92,109,130,158,173,182,211],"1":[8,31,74,93,110,131,159,174,183,212],"physiology":[9],"and":[10,20,25,38,54,64,94,104,119,122,141,152,163,199,239],"its":[11,95],"various":[12],"sites":[13],"of":[14,194,206,224,227,233],"action":[15],"beyond":[16],"the":[17,60,102,127,203,222,231],"incretin":[18,35],"effect":[19,145],"highlights":[21],"recent":[22,164,204],"findings":[23,220],"(2005":[24],"2006).":[26],"RECENT":[27],"FINDINGS:":[28],"Glucagon-like":[29,91,108,181],"is":[32,46,75,184],"a":[33,143,187,191],"physiological":[34],"in":[36,101,137,149],"humans":[37],"promotes":[39],"insulin":[40],"secretion":[41],"after":[42,52,67],"nutrient":[43],"ingestion.":[44],"It":[45],"secreted":[47],"from":[48],"intestinal":[49],"L":[50],"cells":[51],"meals":[53],"may":[55],"be":[56],"partially":[57],"responsible":[58],"for":[59,215,230],"improved":[61],"glycemic":[62],"control":[63,120],"weight":[65],"loss":[66],"bariatric":[68],"surgery.":[69],"In":[70,126],"vivo,":[71],"quickly":[76],"degraded":[77],"by":[78,170],"dipetidyl":[79],"peptidase":[80],"IV":[81],"to":[82,197],"1(9-36),":[85],"which":[86,171],"has":[87,142],"unclear":[88],"physiologic":[89],"activity.":[90],"specific":[96],"receptor":[97,132,175,213],"are":[98],"also":[99],"expressed":[100],"brain,":[103],"central":[105],"nervous":[106],"system.":[107],"can":[111],"reduce":[112],"food":[113],"intake,":[114],"mediate":[115],"toxic":[116],"illness":[117],"responses":[118],"muscle":[121],"liver":[123],"glucose":[124],"disposal.":[125],"heart,":[128],"activation":[133],"improves":[134],"cardiac":[135],"hemodynamics":[136],"patients":[138],"following":[139],"angioplasty":[140],"beneficial":[144],"on":[146,209],"myocardial":[147],"function":[148],"heart":[150],"failure":[151],"postischemic":[153],"animal":[154],"models.":[155],"Finally,":[156],"augments":[160],"islet":[161],"mass":[162],"studies":[165],"have":[166],"identified":[167],"cellular":[168],"mechanisms":[169],"signaling":[176,214],"affects":[177],"this":[178,228],"process.":[179],"SUMMARY:":[180],"emerging":[185],"as":[186,237],"regulatory":[188],"factor":[189],"with":[190],"broad":[192],"range":[193],"actions":[195],"related":[196],"substrate":[198],"energy":[200],"metabolism.":[201],"With":[202],"development":[205],"medications":[207],"based":[208],"diabetes":[216],"treatment,":[217],"these":[218],"new":[219],"suggest":[221],"promise":[223],"further":[225],"application":[226],"system":[229],"treatment":[232],"other":[234],"conditions":[235],"such":[236],"obesity":[238],"cardiovascular":[240],"disease.":[241]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}