{"id":"https://openalex.org/W2321534064","doi":"https://doi.org/10.1021/ja204466y","title":"Odd\u2013Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles","display_name":"Odd\u2013Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles","publication_year":2011,"publication_date":"2011-08-31","ids":{"openalex":"https://openalex.org/W2321534064","doi":"https://doi.org/10.1021/ja204466y","mag":"2321534064","pmid":"https://pubmed.ncbi.nlm.nih.gov/21879762"},"language":"en","primary_location":{"id":"doi:10.1021/ja204466y","doi":"https://doi.org/10.1021/ja204466y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja204466y","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2321534064"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090651125","display_name":"Hirokuni Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokuni Uchida","raw_affiliation_strings":["Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8656, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019665426","display_name":"Kanjiro Miyata","orcid":"https://orcid.org/0000-0001-7044-190X","observed_orcids":["https://orcid.org/0000-0001-7044-190X"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanjiro Miyata","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029436173","display_name":"Makoto Oba","orcid":"https://orcid.org/0000-0002-3691-3608","observed_orcids":["https://orcid.org/0000-0002-3691-3608"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Oba","raw_affiliation_strings":["Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takehiko Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Ishii","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan","\u2020 Department of Bioengineering and \u2021 Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan","Univ.\\ of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"\u2020 Department of Bioengineering and \u2021 Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Univ.\\ of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030281678","display_name":"Tomoya Suma","orcid":"https://orcid.org/0000-0002-3572-8988","observed_orcids":["https://orcid.org/0000-0002-3572-8988"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Suma","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan","\u2020 Department of Bioengineering and \u2021 Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan","Univ.\\ of Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Clinical Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"\u2020 Department of Bioengineering and \u2021 Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Univ.\\ of Tokyo","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039852265","display_name":"Keiji Itaka","orcid":"https://orcid.org/0000-0001-5132-5356","observed_orcids":["https://orcid.org/0000-0001-5132-5356"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiji Itaka","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086040518","display_name":"Nobuhiro Nishiyama","orcid":"https://orcid.org/0000-0002-6886-9357","observed_orcids":["https://orcid.org/0000-0002-6886-9357"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Nishiyama","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015097923","display_name":"Kazunori Kataoka","orcid":"https://orcid.org/0000-0002-8591-413X","observed_orcids":["https://orcid.org/0000-0002-8591-413X"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazunori Kataoka","raw_affiliation_strings":["Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015097923"],"corresponding_institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.9486,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.98292141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"133","issue":"39","first_page":"15524","last_page":"15532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/odd-even-effect","display_name":"odd-even effect","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.765999972820282},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.7910000085830688},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/buffering-capacity","display_name":"buffering capacity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/endosomal-membrane-disruption","display_name":"endosomal membrane disruption","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protonated-amino-groups","display_name":"protonated amino groups","score":0.7799999713897705},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9732424020767212},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.8121523857116699},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7722293138504028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5175046920776367},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3408457040786743},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3346351385116577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20887193083763123},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1713179647922516},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06668394804000854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005030","descriptor_name":"Ethylenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja204466y","doi":"https://doi.org/10.1021/ja204466y","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja204466y","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:21879762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21879762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2305890957","display_name":"siRNA\u3092\u30d3\u30eb\u30c7\u30a3\u30f3\u30b0\u30d6\u30ed\u30c3\u30af\u3068\u3059\u308b\u8d85\u5206\u5b50\u69cb\u9020\u4f53\u306e\u5275\u51fa\u3068\u6a5f\u80fd\u958b\u767a","funder_award_id":"23350049","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4909365291","display_name":"Development of Novel Therapeutic Angiogenesis Method by Combination of Nanotechnology and siRNA Targeting PHD2","funder_award_id":"21659299","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5273087352","display_name":"Development of functional polymer-siRNA conjugates for siRNA delivery","funder_award_id":"22700489","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5350101204","display_name":"Development of systemically injectable siRNA delivery systems by fine-tuning of block copolymers","funder_award_id":"23390009","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W91990295","https://openalex.org/W1602020336","https://openalex.org/W1965303180","https://openalex.org/W1967078049","https://openalex.org/W1989754961","https://openalex.org/W1995997091","https://openalex.org/W1997297466","https://openalex.org/W1997993853","https://openalex.org/W1998697301","https://openalex.org/W2002151233","https://openalex.org/W2003414091","https://openalex.org/W2004180909","https://openalex.org/W2010655741","https://openalex.org/W2012889187","https://openalex.org/W2013440899","https://openalex.org/W2023104469","https://openalex.org/W2023532191","https://openalex.org/W2033126801","https://openalex.org/W2034258616","https://openalex.org/W2036747281","https://openalex.org/W2046695376","https://openalex.org/W2048934762","https://openalex.org/W2057576065","https://openalex.org/W2058485009","https://openalex.org/W2064410724","https://openalex.org/W2074261584","https://openalex.org/W2086069830","https://openalex.org/W2087147942","https://openalex.org/W2104451045","https://openalex.org/W2139251684","https://openalex.org/W2152376500","https://openalex.org/W2156440836","https://openalex.org/W2156769138","https://openalex.org/W2163371839"],"related_works":["https://openalex.org/W2313346879","https://openalex.org/W2087147942","https://openalex.org/W2292102791","https://openalex.org/W2560261873","https://openalex.org/W2070836823","https://openalex.org/W1569631735","https://openalex.org/W2788940371","https://openalex.org/W7131638391","https://openalex.org/W2003017093","https://openalex.org/W2033029089"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,39,48,61,81,89,99,106,120,142,149,174,181],"the":[3,11,49,54,59,75,100,117,143,147,162,175,182,185],"N-substituted":[4,31],"polyaspartamides":[5,32],"possessing":[6],"repeating":[7,50,82,107],"aminoethylene":[8,51,83,108],"units":[9,52,84,109],"in":[10,16,53,161],"side":[12,56,164],"chain":[13,57,165],"was":[14,70,166],"prepared":[15],"this":[17],"study":[18],"to":[19,66,128,137,168,195],"identify":[20],"polyplexes":[21,73],"with":[22,77,102,116,154],"effective":[23,139,172],"endosomal":[24,62,134,140,176],"escape":[25,63,141],"and":[26,64,198],"low":[27],"cytotoxicity.":[28],"All":[29],"cationic":[30],"showed":[33],"appreciably":[34],"lower":[35],"cytotoxicity":[36],"than":[37,97],"that":[38],"commercial":[40],"transfection":[41,65,92],"reagents.":[42],"Interestingly,":[43],"a":[44,150],"distinctive":[45],"odd-even":[46,112],"effect":[47,113],"polymer":[55,163],"on":[58],"efficiencies":[60],"several":[67],"cell":[68],"lines":[69],"observed.":[71],"The":[72],"from":[74],"polymers":[76,101,122],"an":[78,87,103],"even":[79],"number":[80,105],"(PA-Es)":[85],"achieved":[86],"order":[88],"magnitude":[90],"higher":[91],"efficiency,":[93],"without":[94],"marked":[95],"cytotoxicity,":[96],"those":[98],"odd":[104],"(PA-Os).":[110],"This":[111],"agreed":[114],"well":[115,124],"buffering":[118],"capacity":[119],"these":[121],"as":[123,125],"their":[126],"capability":[127],"disrupt":[129],"membrane":[130],"integrity":[131],"selectively":[132],"at":[133],"pH,":[135],"leading":[136],"highly":[138],"PA-E":[144],"polyplexes.":[145],"Furthermore,":[146],"formation":[148],"polyvalent":[151],"charged":[152],"array":[153],"precise":[155],"spacing":[156],"between":[157],"protonated":[158],"amino":[159],"groups":[160],"shown":[167],"be":[169],"essential":[170],"for":[171,192],"disruption":[173],"membrane,":[177],"thus":[178],"facilitating":[179],"transport":[180],"polyplex":[183],"into":[184],"cytoplasm.":[186],"These":[187],"data":[188],"provide":[189],"useful":[190],"knowledge":[191],"designing":[193],"polycations":[194],"construct":[196],"safe":[197],"efficient":[199],"nonviral":[200],"gene":[201],"carriers.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}