{"id":"https://openalex.org/W2321396218","doi":"https://doi.org/10.1097/md.0000000000002005","title":"Continuous Local Infiltration Analgesia for Pain Control After Total Knee Arthroplasty","display_name":"Continuous Local Infiltration Analgesia for Pain Control After Total Knee Arthroplasty","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2321396218","doi":"https://doi.org/10.1097/md.0000000000002005","mag":"2321396218","pmid":"https://pubmed.ncbi.nlm.nih.gov/26559294","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4912288"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000002005","doi":"https://doi.org/10.1097/md.0000000000002005","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000002005","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000002005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067276196","display_name":"Xiaolei Sun","orcid":"https://orcid.org/0000-0003-1690-8980","observed_orcids":["https://orcid.org/0000-0003-1690-8980"]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Lei Sun","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM); and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM); and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I4210142182","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056714525","display_name":"Zhihu Zhao","orcid":"https://orcid.org/0000-0001-7081-8914","observed_orcids":["https://orcid.org/0000-0001-7081-8914"]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Hu Zhao","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102909209","display_name":"Jianxiong Ma","orcid":"https://orcid.org/0000-0001-6346-6316","observed_orcids":["https://orcid.org/0000-0001-6346-6316"]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Xiong Ma","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051700141","display_name":"Fengbo Li","orcid":"https://orcid.org/0000-0002-1660-7830","observed_orcids":["https://orcid.org/0000-0002-1660-7830"]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng-Bo Li","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan-Jun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Jun Li","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004913973","display_name":"Xinmin Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Min Meng","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM); and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM); and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I4210142182","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101450001","display_name":"Xinlong Ma","orcid":"https://orcid.org/0000-0001-9218-7092","observed_orcids":["https://orcid.org/0000-0001-9218-7092"]},"institutions":[{"id":"https://openalex.org/I4210142182","display_name":"Tianjin Hospital","ror":"https://ror.org/04j9yn198","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142182"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin-Long Ma","raw_affiliation_strings":["From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","Accepted October 16, 2015","Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","Received August 4, 2015","Received in revised form October 16, 2015","The authors have conflicts of interest to disclose","This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","X-LS and Z-HZ are co-first authors for this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Orthopaedics, Tianjin Hospital (X-LS, Z-HZ, J-XM, F-BL, Y-JL, X-MM, X-LM)","institution_ids":["https://openalex.org/I4210142182"]},{"raw_affiliation_string":"and Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Abbreviations: CI = confidence interval, CLIA = continuous local infiltration analgesia, DVT = deep venous thrombosis, LIA = local infiltration analgesia, LOS = length of hospital stay, PE = pulmonary embolism, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-analyses, RA = rheumatic arthritis, RCTs = randomized controlled trials, RR = relative risk, SLIA = single-injection local infiltration analgesia, SMD = standardized mean difference, TKA = total knee arthroplasty, VAS = visual analog scale","institution_ids":[]},{"raw_affiliation_string":"Accepted October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"Funding: This study was supported by National Natural Science Foundation (81401792) and National Natural Science Foundation (81501061)","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Tianjin Medical University, Tianjin, China (Z-HZ)","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Received August 4, 2015","institution_ids":[]},{"raw_affiliation_string":"Received in revised form October 16, 2015","institution_ids":[]},{"raw_affiliation_string":"The authors have conflicts of interest to disclose","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0","institution_ids":[]},{"raw_affiliation_string":"X-LS and Z-HZ are co-first authors for this article","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101450001","https://openalex.org/A5102909209"],"corresponding_institution_ids":["https://openalex.org/I4210142182","https://openalex.org/I5740404"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":1.7202,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.82402707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"94","issue":"45","first_page":"e2005","last_page":"e2005"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9929999709129333},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9169999957084656},{"id":"https://openalex.org/keywords/postoperative-analgesia","display_name":"postoperative analgesia","score":0.7829999923706055},{"id":"https://openalex.org/keywords/visual-analog-scale","display_name":"visual analogue scale","score":0.6880000233650208},{"id":"https://openalex.org/keywords/postoperative-mobilization","display_name":"postoperative mobilization","score":0.6759999990463257},{"id":"https://openalex.org/keywords/postoperative-infection","display_name":"postoperative infection","score":0.6039999723434448},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.7269999980926514},{"id":"https://openalex.org/keywords/analgesic-safety","display_name":"analgesic safety","score":0.5440000295639038},{"id":"https://openalex.org/keywords/local-anesthetic-infusion","display_name":"local anesthetic infusion","score":0.40799999237060547},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.38499999046325684},{"id":"https://openalex.org/keywords/knee-range-of-motion","display_name":"knee range of motion","score":0.3889999985694885},{"id":"https://openalex.org/keywords/knee-flexion-angle","display_name":"knee flexion angle","score":0.5580000281333923},{"id":"https://openalex.org/keywords/hamstring-strength","display_name":"hamstring strength","score":0.3059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9531871676445007},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7263444662094116},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.6419122219085693},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.579492449760437},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5540136098861694},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5399330854415894},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.539207398891449},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.5223682522773743},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5139314532279968},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.48122215270996094},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.47319909930229187},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.439352422952652},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2759789824485779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1657252013683319},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.09551581740379333},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013530","descriptor_name":"Surgical Wound Infection","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D057785","descriptor_name":"Catheters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000002005","doi":"https://doi.org/10.1097/md.0000000000002005","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000002005","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4912288","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4912288/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4912288/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:26559294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26559294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000002005","doi":"https://doi.org/10.1097/md.0000000000002005","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000002005","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2321396218.pdf","grobid_xml":"https://content.openalex.org/works/W2321396218.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W98600822","https://openalex.org/W129056722","https://openalex.org/W1527227620","https://openalex.org/W1708351752","https://openalex.org/W1957540814","https://openalex.org/W1976662683","https://openalex.org/W1979354409","https://openalex.org/W1979705790","https://openalex.org/W1984519032","https://openalex.org/W1987755627","https://openalex.org/W1992205326","https://openalex.org/W2008661754","https://openalex.org/W2016461191","https://openalex.org/W2021180004","https://openalex.org/W2022993650","https://openalex.org/W2028741437","https://openalex.org/W2038845082","https://openalex.org/W2044117909","https://openalex.org/W2047965389","https://openalex.org/W2068506572","https://openalex.org/W2077010527","https://openalex.org/W2086383526","https://openalex.org/W2092625222","https://openalex.org/W2093717254","https://openalex.org/W2094136715","https://openalex.org/W2094686591","https://openalex.org/W2102481092","https://openalex.org/W2103112341","https://openalex.org/W2104230558","https://openalex.org/W2104631455","https://openalex.org/W2209837560","https://openalex.org/W2331434879"],"related_works":["https://openalex.org/W1468353816","https://openalex.org/W7073569300","https://openalex.org/W2505000788","https://openalex.org/W2806097972","https://openalex.org/W2404460296","https://openalex.org/W4360600295","https://openalex.org/W2403470999","https://openalex.org/W2028336454","https://openalex.org/W4406738196","https://openalex.org/W2044117909"],"abstract_inverted_index":{"A":[0],"total":[1],"knee":[2],"arthroplasty":[3],"(TKA)":[4],"has":[5],"always":[6],"been":[7],"associated":[8],"with":[9,136,220,237,264,298,304,417,425,476,487],"moderate":[10],"to":[11,28,37,60,112,169,234,247,257,266,280,293,311,364,377,391],"severe":[12],"pain.":[13],"As":[14],"more":[15,405,471],"research":[16],"is":[17,35],"conducted":[18,84],"on":[19],"the":[20,39,44,62,86,113,128,148,171,181,206,267,319,334,354,397,400,412,430,439,445],"use":[21],"of":[22,43,49,55,66,69,96,150,157,173,321,336,356,384,399,432,441,447,455,464,484],"continuous":[23,213],"local":[24],"infiltration":[25],"analgesia":[26,215],"(CLIA)":[27],"manage":[29],"pain":[30,67,151,218,410],"after":[31,73,133,153],"a":[32,74,79,134,452,461],"TKA,":[33],"it":[34,162,428],"necessary":[36,480],"reassess":[38],"efficacy":[40,63],"and":[41,53,64,100,107,120,143,160,188,236,249,285,300,333,419,422,460],"safety":[42,65,172],"TKA":[45,135],"method.":[46],"The":[47,124,155,209],"purpose":[48],"this":[50,468,485],"systematic":[51,80,105],"review":[52,106],"meta-analysis":[54,108,210],"randomized":[56,473],"controlled":[57,474],"trials":[58,475],"was":[59,83,127,178,260,404,450],"evaluate":[61],"control":[68,152,219],"CLIA":[70,317,403,435,478],"versus":[71],"placebo":[72,413],"TKA.":[75,154],"In":[76],"January":[77],"2015,":[78],"computer-based":[81],"search":[82],"in":[85,353,467],"Medline,":[87],"Embase,":[88],"PubMed,":[89],"CENTRAL":[90],"(Cochrane":[91],"Controlled":[92],"Trials":[93],"Register),":[94],"Web":[95],"Science,":[97],"Google":[98],"database,":[99],"Chinese":[101],"Wanfang":[102],"databases.":[103],"This":[104],"were":[109,166,193,349],"performed":[110],"according":[111],"Preferred":[114],"Reporting":[115],"Items":[116],"for":[117,180,185,195,407,481],"Systematic":[118],"Reviews":[119],"Meta-analyses":[121],"statement":[122],"criteria.":[123,208],"primary":[125],"endpoint":[126],"visual":[129,268],"analog":[130,269],"scale":[131,270],"score":[132,271],"rest":[137,221,299,418],"or":[138,338,382,444],"mobilization":[139,238,305],"at":[140,222,239,272,301,414,420],"24,":[141],"48,":[142],"72":[144,286,302],"hours,":[145],"which":[146],"represents":[147],"effect":[149],"complications":[156],"infection,":[158],"nausea,":[159],"whether":[161],"prolonged":[163],"wound":[164],"drainage":[165],"also":[167,451],"compiled":[168],"assess":[170],"CLIA.":[174],"RevMan":[175],"5.30":[176],"software":[177],"used":[179],"meta-analysis.":[182],"After":[183],"testing":[184],"publication":[186],"bias":[187,466],"heterogeneity":[189,454],"across":[190],"studies,":[191],"data":[192],"aggregated":[194],"random-effects":[196],"modeling":[197],"when":[198],"necessary.":[199],"Ten":[200],"studies":[201],"involving":[202],"735":[203],"patients":[204],"met":[205],"inclusion":[207],"revealed":[211],"that":[212],"infusion":[214],"provided":[216],"better":[217],"24":[223,240,415,421],"hours":[224,241,251,274,287,303,416,424],"(mean":[225],"difference":[226,263],"[MD]":[227],"-12.54,":[228],"95%":[229,244,254,277,290,308,327,342,361,374,388],"confidence":[230],"interval":[231],"[CI]":[232],"-16.63":[233],"8.45),":[235],"(MD":[242,252,275,288,306,359,386],"-18.27,":[243],"CI":[245,255,278,291,309,328,343,362,375,389],"-27.52":[246],"9.02)":[248],"48":[250,273,423],"-14.19,":[253],"-21.46":[256],"6.93).":[258],"There":[259,348,449],"no":[261,350],"significant":[262,351],"respect":[265],"-6.15,":[276],"-13.51":[279],"1.22,":[281],"P":[282,295,313,330,345,366,379,393],"=":[283,296,314,331,346,367,380,394],"0.10)":[284],"-3.63,":[289],"-10.43":[292],"3.16,":[294,326],"0.29)":[297],"-4.25,":[307],"-16.27":[310],"7.77,":[312],"0.49).":[315],"However,":[316,434],"increased":[318,429],"rate":[320,335],"infection":[322],"(relative":[323],"risk":[324,431,463],"[RR]":[325],"1.18-8.50,":[329],"0.02)":[332],"nausea":[337],"vomiting":[339],"(RR":[340,372],"0.60,":[341],"0.37-0.96,":[344],"0.03).":[347],"differences":[352],"length":[355,440],"hospital":[357,442],"stay":[358,443],"-0.34,":[360],"-1.09":[363],"0.42,":[365],"0.38),":[368],"deep":[369],"venous":[370],"thrombosis":[371],"1.02,":[373],"0.30":[376],"1.41,":[378],"0.99),":[381],"duration":[383,446],"surgery":[385],"1.20,":[387],"-4.59":[390],"6.98,":[392],"0.69).":[395],"On":[396],"basis":[398],"current":[401],"meta-analysis,":[402],"efficacious":[406],"reducing":[408],"postoperative":[409],"than":[411],"mobilization,":[426],"but":[427],"infection.":[433],"did":[436],"not":[437],"prolong":[438],"surgery.":[448],"higher":[453],"different":[456],"analgesic":[457],"drugs":[458],"mixed":[459],"high":[462],"selection":[465],"analysis;":[469],"therefore,":[470],"high-quality":[472],"standardized":[477],"are":[479],"proper":[482],"comparisons":[483],"technique":[486],"other":[488],"methods.":[489]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}