{"id":"https://openalex.org/W2321382379","doi":"https://doi.org/10.1021/jm300274p","title":"Lipo-\u03b3-AApeptides as a New Class of Potent and Broad-Spectrum Antimicrobial Agents","display_name":"Lipo-\u03b3-AApeptides as a New Class of Potent and Broad-Spectrum Antimicrobial Agents","publication_year":2012,"publication_date":"2012-04-04","ids":{"openalex":"https://openalex.org/W2321382379","doi":"https://doi.org/10.1021/jm300274p","mag":"2321382379","pmid":"https://pubmed.ncbi.nlm.nih.gov/22475244"},"language":"en","primary_location":{"id":"doi:10.1021/jm300274p","doi":"https://doi.org/10.1021/jm300274p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm300274p","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103097078","display_name":"Youhong Niu","orcid":"https://orcid.org/0000-0001-5645-9943","observed_orcids":["https://orcid.org/0000-0001-5645-9943"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youhong Niu","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084693642","display_name":"Shruti Padhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Padhee","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021058604","display_name":"Haifan Wu","orcid":"https://orcid.org/0000-0002-2050-9950","observed_orcids":["https://orcid.org/0000-0002-2050-9950"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haifan Wu","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080477732","display_name":"Ge Bai","orcid":"https://orcid.org/0000-0001-7768-3119","observed_orcids":["https://orcid.org/0000-0001-7768-3119"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Bai","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101525476","display_name":"Qiao Qiao","orcid":"https://orcid.org/0000-0002-6841-3771","observed_orcids":["https://orcid.org/0000-0002-6841-3771"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiao Qiao","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110190703","display_name":"Yaogang Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaogang Hu","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030755965","display_name":"Lacey Harrington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lacey Harrington","raw_affiliation_strings":["Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008563132","display_name":"Whittney N. Burda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Whittney N. Burda","raw_affiliation_strings":["Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016887105","display_name":"Lindsey Neil Shaw","orcid":"https://orcid.org/0000-0002-0629-8990","observed_orcids":["https://orcid.org/0000-0002-0629-8990","https://orcid.org/0000-0002-2211-0556"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey N. Shaw","raw_affiliation_strings":["Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology,\rMicrobiology and Molecular Biology, University South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620,\rUnited States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054451714","display_name":"Chuanhai Cao","orcid":"https://orcid.org/0000-0002-5765-6401","observed_orcids":["https://orcid.org/0000-0002-5765-6401","https://orcid.org/0009-0000-6298-8761"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuanhai Cao","raw_affiliation_strings":["USF College of Pharmacy, 4001 E. Fletcher Avenue, Tampa,\rFlorida 33613, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USF College of Pharmacy, 4001 E. Fletcher Avenue, Tampa,\rFlorida 33613, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110862767","display_name":"Jianfeng Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianfeng Cai","raw_affiliation_strings":["Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, CHE\r205, University of South Florida, 4202\rE. Fowler Avenue, Tampa, Florida 33620, United States","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110862767"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":7.771,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.98271383,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"55","issue":"8","first_page":"4003","last_page":"4009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lipidated-peptides","display_name":"lipidated peptides","score":0.6970000267028809},{"id":"https://openalex.org/keywords/broad-spectrum-antimicrobial-activity","display_name":"broad-spectrum antimicrobial activity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6010000109672546},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.7549999952316284},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.7110000252723694},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.9295647144317627},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7239744663238525},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7072477340698242},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5531845092773438},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5297363996505737},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5196172595024109},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.510515570640564},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5042709112167358},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.48821714520454407},{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.4185947775840759},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28073328733444214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23771193623542786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18404000997543335},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.14909237623214722},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0992007851600647},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055666","descriptor_name":"Lipopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D057786","descriptor_name":"Peptidomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm300274p","doi":"https://doi.org/10.1021/jm300274p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm300274p","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:22475244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22475244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1501359805","https://openalex.org/W1967631524","https://openalex.org/W1968563250","https://openalex.org/W1975128800","https://openalex.org/W1975313075","https://openalex.org/W1986159104","https://openalex.org/W1991655763","https://openalex.org/W1993906884","https://openalex.org/W1997152791","https://openalex.org/W2004373761","https://openalex.org/W2010666335","https://openalex.org/W2011615074","https://openalex.org/W2013588942","https://openalex.org/W2015271074","https://openalex.org/W2020673265","https://openalex.org/W2020873347","https://openalex.org/W2024334224","https://openalex.org/W2025194131","https://openalex.org/W2026136710","https://openalex.org/W2026591577","https://openalex.org/W2032992313","https://openalex.org/W2036628662","https://openalex.org/W2048048854","https://openalex.org/W2050140989","https://openalex.org/W2054436131","https://openalex.org/W2058952776","https://openalex.org/W2067431105","https://openalex.org/W2079789322","https://openalex.org/W2079831603","https://openalex.org/W2081277508","https://openalex.org/W2085436481","https://openalex.org/W2095191890","https://openalex.org/W2095282589","https://openalex.org/W2104476418","https://openalex.org/W2130885148","https://openalex.org/W2159051700","https://openalex.org/W2161508942","https://openalex.org/W2162107182","https://openalex.org/W2917702355"],"related_works":["https://openalex.org/W2161508942","https://openalex.org/W1983535542","https://openalex.org/W2332717345","https://openalex.org/W4361302156","https://openalex.org/W2104971644","https://openalex.org/W7001028915","https://openalex.org/W2112305275","https://openalex.org/W2990286286","https://openalex.org/W2409294497","https://openalex.org/W7166722440"],"abstract_inverted_index":{"There":[0],"is":[1],"increasing":[2],"demand":[3],"to":[4,19,84,145],"develop":[5],"antimicrobial":[6,29,59,94],"peptides":[7],"(AMPs)":[8],"as":[9,14,37,58,153],"next":[10],"generation":[11],"antibiotic":[12,26,159],"agents,":[13],"they":[15,38],"have":[16,39,88,141,150],"the":[17,50,53,115,139],"potential":[18,152],"circumvent":[20],"emerging":[21],"drug":[22,124],"resistance":[23,125],"against":[24,67],"conventional":[25],"treatments.":[27],"Non-natural":[28],"peptidomimetics":[30],"are":[31,82],"an":[32],"ideal":[33],"example":[34],"of":[35,55,72,104,133,147,157],"this,":[36],"significant":[40],"potency":[41],"and":[42,69,74,93,99,112,149],"in":[43,126],"vivo":[44],"stability.":[45],"Here":[46],"we":[47],"report":[48],"for":[49],"first":[51],"time":[52],"design":[54],"lipidated":[56],"\u03b3-AApeptides":[57],"agents.":[60],"These":[61,135],"lipo-\u03b3-AApeptides":[62,140],"show":[63],"potent":[64],"broad-spectrum":[65],"activities":[66],"fungi":[68],"a":[70,118,154],"series":[71],"Gram-positive":[73],"Gram-negative":[75],"bacteria,":[76],"including":[77],"clinically":[78],"relevant":[79],"pathogens":[80],"that":[81,138],"resistant":[83],"most":[85],"antibiotics.":[86],"We":[87],"analyzed":[89],"their":[90],"structure-function":[91],"relationship":[92],"mechanisms":[95,143],"using":[96],"membrane":[97],"depolarization":[98],"fluorescent":[100],"microscopy":[101],"assays.":[102],"Introduction":[103],"unsaturated":[105],"lipid":[106],"chain":[107],"significantly":[108],"decreases":[109],"hemolytic":[110],"activity":[111],"thereby":[113],"increases":[114],"selectivity.":[116],"Furthermore,":[117],"representative":[119],"lipo-\u03b3-AApeptide":[120],"did":[121],"not":[122],"induce":[123],"S.":[127],"aureus,":[128],"even":[129],"after":[130],"17":[131],"rounds":[132],"passaging.":[134],"results":[136],"suggest":[137],"bactericidal":[142],"analogous":[144],"those":[146],"AMPs":[148],"strong":[151],"new":[155],"class":[156],"novel":[158],"therapeutics.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
